by Adam Le Gresley, PhD

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    In the previous lecture, we talked about the reactions of amines with carboxylic acid derivatives so that we could form amides, a very important functional group, both in terms of chemistry and also in biology. But, it’s important that we actually deal with amines on their own to some extent, not least because they form some… they form some of the most important chemicals within our body. Okay. So, let’s first and foremost look at the nomenclature. First and foremost, where we have an amine, which consists of an alkyl or aryl group, represented here as “R”, we use the longest chain, as we do in all cases. So, in other words, if it was two carbon units, it would be ether; three would be propyl; four would be butyl; and so on and so forth. And then we remove the “e” at the end, and we attach the suffix “-amine”. There is sometimes a number prefix to indicate the position of the amine on the chain by the lowest possible number. What does that actually mean? Well, let’s have a look at a couple of examples. If we look at 2-pentylamine, you can see what I said before. When you have a substituent on a long chain, as you’ve seen here, where you’ve got a pentane chain, five carbons in length, what we need to do is find the carbon to which the hetero atom is attached. In the case of alcohols, it is OH. In the case of haloalkanes, it is chlorine, bromine or fluorine. And in the case of amines, it is nitrogen. Nitrogen has an atomic mass of 14, carbon of 12, therefore, nitrogen takes priority. When, of course, the nitrogen is in a terminal position, then of course, it is that carbon to which it’s...

    About the Lecture

    The lecture Amines by Adam Le Gresley, PhD is from the course Medical Chemistry. It contains the following chapters:

    • Amines
    • Physical and chemical properties
    • Preparation of amines
    • Amino acids
    • Amino acids, Peptides and Proteins

    Included Quiz Questions

    1. decrease ; ortho or para
    2. increase ; ortho or para
    3. increase ; meta
    4. decrease ; meta
    5. None of the above

    Author of lecture Amines

     Adam Le Gresley, PhD

    Adam Le Gresley, PhD

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