Las interleucinas son un tipo de citoquinas (proteínas de señalización) que comunican mensajes entre diferentes partes del sistema inmunitario. La mayoría de las interleucinas son sintetizadas por losLOSNeisseria linfocitos T CD4 colaborador junto con otras células como losLOSNeisseria monocitos, losLOSNeisseria macrófagos y las células endoteliales. Las interleucinas son la base del desarrollo y la diferenciación de losLOSNeisseria linfocitos T y B y de las células hematopoyéticas.
“Leucina”, que es el origen de la palabra “leucocito”
EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum conjunto, la palabra interleucina se refiere a una molécula que desempeña un papel enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la comunicación entre losLOSNeisseria componentes celulares del sistema inmunitario.
La función principal de las interleucinas es modular el crecimiento, la diferenciación y la activación de las células inmunitarias durante las respuestas inflamatorias e inmunitarias.
Las interleucinas desempeñan un papel enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las respuestas inmunitarias innata y adaptativa.
Las interleucinas se producen enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum respuesta a:
Patógenos
Autoantígenos
Otras interleucinas
Las interleucinas influyen enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la síntesis y acciones de otras interleucinas (e.g., la IL-1 estimula la liberación de IL-2).
Solo se necesitan cantidades muy pequeñas de interleucina para ocupar losLOSNeisseria receptores y provocar efectos biológicos.
Las interleucinas son un grupo diverso de moléculas con diferentes estructuras proteicas.
Se han identificado y descrito aproximadamente 35 interleucinas.
Tabla: Las interleucinas y sus efectos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las células diana
Nombre
Fuente
Células diana
Efecto sobre las células diana
IL-1
Macrófagos y monocitos
Células B
Células dendríticas
Células endoteliales
Fibroblastos
Astrocitos
Células T colaborador
Células B
Macrófagos
Endotelio
Inflamatoria
Induce la maduración, activación y proliferación de losLOSNeisseria linfocitos
Pirógeno
Promueve la secreción de citoquinas y proteínas de fase aguda
Aumenta la adhesión leucocitaria-endotelial
IL-2
Células T
Células T
Células B
Células NK
Macrófagos
Estimula el crecimiento y la diferenciación de las células T
Previene el desarrollo de células T que atacan a losLOSNeisseria auto-antígenos
IL-3
Células T
Células madre hematopoyéticas
Macrófagos
Mastocitos
Diferenciación y proliferación de células progenitoras mieloides a eritrocitos y granulocitos
Liberación de histamina
IL-4
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Mastocitos
Células T
Células B
Macrófagos
Diferenciación de las células T enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Factor de crecimiento de las células B
Producción de IgG1 e IgEIgEAn immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity.Immunoglobulins: Types and Functions
IL-5
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Células B
Eosinófilos
Crecimiento y diferenciación de las células B
Producción de IgAIgARepresents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory iga is the main immunoglobulin in secretions.Immunoglobulins: Types and Functions
Crecimiento, diferenciación y activación de losLOSNeisseria eosinófilos
IL-6
Macrófagos
Células T
Células B
Astrocitos
Fibroblastos
Células endoteliales
Células B
Células madre hematopoyéticas
Células T
Diferenciación de las células B y T
Diferenciación y proliferación de células madre y progenitoras
Secreción de anticuerpos
Pirógeno
Síntesis de proteínas de fase aguda
IL-7IL-7A proinflammatory cytokine produced primarily by T-lymphocytes or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Severe Combined Immunodeficiency (SCID)
Células estromales de la médula ósea
Células estromales del timo
Células pre-B
Células pre-T
Diferenciación y proliferación de células progenitoras linfoides
Supervivencia de las células T y secreción de citoquinas
Crecimiento y activación de mastocitos
IL-10
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Mastocitos
Macrófagos
Células B
Macrófagos
Células B
Células Th1Th1A subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2; interferon-gamma; and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, th1 cells are associated with vigorous delayed-type hypersensitivity reactions.T cells: Types and Functions
Células dendríticas
Inhibe la producción de citoquinas Th1Th1A subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2; interferon-gamma; and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, th1 cells are associated with vigorous delayed-type hypersensitivity reactions.T cells: Types and Functions (IFN-γ, TNF-β, IL-2)
Inhibe la producción de IL-12 de losLOSNeisseria macrófagos
Disminuye la expresión del CMH clase II enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las células dendríticas
IL-11
Células estromales de la médula ósea
Fibroblastos
Células progenitoras hematopoyéticas
Osteoclastos
Producción de proteínas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum fase aguda
Formación de osteoclastos
IL-12
Células dendríticas
Células B
Células T
Macrófagos
Neutrófilos
Células T
Células NK
Diferenciación enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum células Th1Th1A subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2; interferon-gamma; and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, th1 cells are associated with vigorous delayed-type hypersensitivity reactions.T cells: Types and Functions
Induce la producción de IFN-γ
IL-13
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Mastocitos
Células NK
Células B
Monocitos
Fibroblastos
Células epiteliales
Crecimiento y diferenciación de las células B
Producción de IgEIgEAn immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity.Immunoglobulins: Types and Functions
Aumento de la producción de moco
Síntesis de colágeno
Inhibe la producción de citoquinas proinflamatorias
Liberación de citoquinas inflamatorias (incluida la IL-6)
Angiogénesis
IL-18
Macrófagos
Células Th1Th1A subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2; interferon-gamma; and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, th1 cells are associated with vigorous delayed-type hypersensitivity reactions.T cells: Types and Functions
Células NK
Producción de IFN-γ
Aumenta la actividad de las células NK
IL-19
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Participa enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la defensa inmunitaria contra losLOSNeisseriavirusVirusViruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology
IL-29
Células dendríticas
Células T
Participa enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la defensa inmunitaria contra losLOSNeisseria microbios
IL-30
Monocitos
Células cancerígenas (posiblemente)
Puede desempeñar un papel enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el crecimiento de losLOSNeisseria tumores
IL-31
Células Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Células dendríticas
Puede desempeñar un papel enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la inflamación de la piel
Induce la producción de citoquinas y quimioquinas
IL-32
Monocitos
Células NK
Induce la producción de citoquinas y quimioquinas
IL-33
Macrófagos
Células dendríticas
Células epiteliales
Activa la respuesta inmunitaria Th2Th2A subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins il-4; il-5; il-6; and il-10. These cytokines influence b-cell development and antibody production as well as augmenting humoral responses.T cells: Types and Functions
Activación de mastocitos y basófilos
IL-34
Monocitos
Macrófagos
MicrogliaMicrogliaThe third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.Nervous System: Histology
Diferenciación, migración y supervivencia de las células presentadoras de antígenos
Importante para estimular la respuesta inmunitaria T colaboradora (Th)1:
Combate losLOSNeisseria patógenos intracelulares (e.g., losLOSNeisseriavirusVirusViruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology)
Importante para la vigilancia de tumores
Se vuelve hiperactivo enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum condiciones autoinmunes
Puede administrarse farmacológicamente:
Usos:
Inmunoterapia para tratar a pacientes con cáncer (melanomaMelanomaMelanoma is a malignant tumor arising from melanocytes, the melanin-producing cells of the epidermis. These tumors are most common in fair-skinned individuals with a history of excessive sun exposure and sunburns. Melanoma y carcinoma renal)
Se haHAHemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis).Hemolytic Anemia utilizado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum ensayos clínicos para aumentar losLOSNeisseria recuentos de CD4 enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum pacientes seropositivos
Efectos adversos:
Fiebre
Fatiga
Confusión
Malestar gastrointestinal
Arritmia
Interleucina-4 e IL-5
La IL-4 y la IL-5 juntas desempeñan un papel importante enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las respuestas alérgicas mediadas por la IgEIgEAn immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity.Immunoglobulins: Types and Functions.
IL-4:
Estimula la síntesis de IgEIgEAn immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity.Immunoglobulins: Types and Functions
Aumenta la adherencia y el paso de losLOSNeisseria linfocitos a través del endotelio
La IL-5 estimula la producción de eosinófilos.
Dianas terapéuticas: El dupilumabDupilumabAsthma Drugs es un anticuerpo monoclonal dirigido alALAmyloidosisreceptorReceptorReceptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell.Receptors de la IL-4; haHAHemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis).Hemolytic Anemia sido aprobado por la Food and Drug Administration (FDA, por sus siglas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés) para tratar el asmaASMAAutoimmune Hepatitis y la dermatitisDermatitisAny inflammation of the skin.Atopic Dermatitis (Eczema) atópica.
Interleucina-6
Reactante de fase aguda
Producida por el hígado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum respuesta a infección o a estrés fisiológico
Estimula las respuestas inmunitarias innatas y adaptativas
Interleucina-12, IL-17 e IL-23
Desempeñan un papel importante enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la patogénesis de la psoriasisPsoriasisPsoriasis is a common T-cell-mediated inflammatory skin condition. The etiology is unknown, but is thought to be due to genetic inheritance and environmental triggers. There are 4 major subtypes, with the most common form being chronic plaque psoriasis. Psoriasis
Dianas de anticuerpos monoclonales utilizados para tratar la psoriasisPsoriasisPsoriasis is a common T-cell-mediated inflammatory skin condition. The etiology is unknown, but is thought to be due to genetic inheritance and environmental triggers. There are 4 major subtypes, with the most common form being chronic plaque psoriasis. Psoriasis
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