Domina Conceptos Médicos

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Haemophilus

Haemophilus Haemophilus Haemophilus is a genus of Gram-negative coccobacilli, all of whose strains require at least 1 of 2 factors for growth (factor V [NAD] and factor X [heme]); therefore, it is most often isolated on chocolate agar, which can supply both factors. The pathogenic species are H. influenzae and H. ducreyi. Haemophilus es un género de cocobacilos Gram-negativos, cuyas cepas requieren al AL Amyloidosis menos de 1 de 2 factores para su crecimiento ( factor V Factor V Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Hemostasis [nicotinamida adenina dinucleótido] y factor X Factor X Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called stuart-prower factor deficiency, may lead to a systemic coagulation disorder. Hemostasis [hemina]); por lo tanto, con mayor frecuencia se aísla en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum agar chocolate, que puede aportar ambos factores. La especie patógena más común es H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus, que se transmite a través de gotitas respiratorias y puede causar epiglotitis, meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis, otitis media y neumonía. H. ducreyi se transmite por contacto sexual y es la causa del chancroide, un tipo de úlcera genital.

Last updated: Apr 29, 2022

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Clasificación

Diagrama de flujo de clasificación de bacterias gram negativas

Bacterias Gram-negativas:
La mayoría de las bacterias se pueden clasificar de acuerdo con un procedimiento de laboratorio llamado tinción de Gram.
Las bacterias con paredes celulares que tienen una capa delgada de peptidoglicano no retienen la tinción de cristal violeta utilizada en la tinción de Gram. Sin embargo, estas bacterias retienen la contratinción de safranina y, por lo tanto, se tiñe de color rojo rosado, lo que las convierte en gram negativas. Estas bacterias pueden clasificarse además según su morfología (diplococos, bastones curvos, bacilos y cocobacilos) y su capacidad para crecer en presencia de oxígeno (aeróbicos frente a anaeróbicos). Las bacterias se pueden identificar de manera más estrecha cultivándolas en medios específicos (agar hierro-triple azúcar (TSI, por sus siglas en inglés)) donde se pueden identificar sus enzimas (ureasa, oxidasa) y se puede probar su capacidad para fermentar lactosa.
* Se tiñe pobremente en la tinción de Gram
** Bastón/cocobacilo pleomórfico
*** Requiere medios de transporte especiales

Imagen por Lecturio.

Características Generales

Características generales de las especies de Haemophilus Haemophilus Haemophilus is a genus of Gram-negative coccobacilli, all of whose strains require at least 1 of 2 factors for growth (factor V [NAD] and factor X [heme]); therefore, it is most often isolated on chocolate agar, which can supply both factors. The pathogenic species are H. influenzae and H. ducreyi. Haemophilus:

  • Cocobacilos pleomórficos gramnegativos
  • Los LOS Neisseria 24 miembros de Haemophilus Haemophilus Haemophilus is a genus of Gram-negative coccobacilli, all of whose strains require at least 1 of 2 factors for growth (factor V [NAD] and factor X [heme]); therefore, it is most often isolated on chocolate agar, which can supply both factors. The pathogenic species are H. influenzae and H. ducreyi. Haemophilus generalmente se cultivan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum placas de agar chocolate, ya que todas las especies requieren de al AL Amyloidosis menos 1 de 2 factores de crecimiento (proporcionados por el agar chocolate, pero no por el agar sangre): factor V Factor V Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Hemostasis (nicotinamida adenina dinucleótido) y factor X Factor X Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called stuart-prower factor deficiency, may lead to a systemic coagulation disorder. Hemostasis (hemina)
    • H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus requiere ambos factores
    • También se puede cultivar en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum agar sangre con Staphylococcus aureus Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications. Brain Abscess, que proporciona factor nicotinamida adenina dinucleótido en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum exceso de sus propias necesidades; se libera hemina de los LOS Neisseria eritrocitos por la acción de las hemolisinas estafilocócicas.
  • La especie H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus se divide en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cepas tipificables (encapsuladas) y no tipificables (no encapsuladas). En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las cepas encapsuladas, se utiliza la cápsula de polisacáridos para serotipificarlas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 6 tipos, de la a a la f, siendo el tipo b (Hib) el más virulento y clínicamente importante.
  • Las cepas de H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus no tipificables ( NTHi NTHi Haemophilus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) también causan enfermedades, especialmente enfermedades de las mucosas de las vías respiratorias superiores, como otitis media, rinosinusitis aguda, bronquitis aguda, exacerbaciones agudas de enfermedad pulmonar obstructiva crónica y neumonía no bacteriémica, y por lo general no son invasivas. H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus también es una de las 4 causas más comunes de conjuntivitis bacteriana en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria Estados Unidos (junto con Staphylococcus aureus Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications. Brain Abscess, Streptococcus pneumoniae, y Moraxella catarrhalis Moraxella catarrhalis Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause meningitis; bacteremia; empyema; pericarditis; and pneumonia. Moraxella)
  • La infección por H. Influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus tipo B es rara en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria países desarrollados debido al AL Amyloidosis uso generalizado de vacunas.

Factores de virulencia de las especies de Haemophilus Haemophilus Haemophilus is a genus of Gram-negative coccobacilli, all of whose strains require at least 1 of 2 factors for growth (factor V [NAD] and factor X [heme]); therefore, it is most often isolated on chocolate agar, which can supply both factors. The pathogenic species are H. influenzae and H. ducreyi. Haemophilus:

  • Antígeno capsular ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las cepas encapsuladas): antifagocítico
  • Proteínas de adhesina (e.g., HMW1, HMW2) median la unión a las células epiteliales humanas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las vías respiratorias.
  • Pili Pili Filamentous or elongated proteinaceous structures which extend from the cell surface in gram-negative bacteria that contain certain types of conjugative plasmid. These pili are the organs associated with genetic transfer and have essential roles in conjugation. Normally, only one or a few pili occur on a given donor cell. This preferred use of ‘pili’ refers to the sexual appendage, to be distinguished from bacterial fimbriae, also known as common pili, which are usually concerned with adhesion. Salmonella y proteína P2 de membrana externa principal: se unen a moléculas que contienen ácido siálico en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las superficies de las células epiteliales
  • Proteasa IgA1: escinde la inmunoglobulina A en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región de unión en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum bisagra, evitando la aglutinación y la eliminación mecánica del patógeno
  • Variación de fases: las proteínas de superficie externa se modifican para adaptarse a los LOS Neisseria cambios en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el entorno del huésped.
  • La producción de biopelículas in vivo es especialmente importante en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la patogenia de la otitis media aguda. (La otitis media aguda es la infección bacteriana pediátrica más común y afecta hasta el 75 % de los LOS Neisseria niños en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algún momento antes de los LOS Neisseria 5 años. S. pneumoniae y H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus, especialmente H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus no tipificable, son responsables de hasta el 80% de otitis media aguda bacterianas).
Haemophilus influenzae en agar sangre

Bacteria Haemophilus influenzae cultivada en una placa de agar sangre.

Imagen: “Haemophilus influenzae 01” por CDC. Licencia: Dominio Público

Related videos

Haemophilus influenzae

La siguiente tabla resume las principales manifestaciones clínicas, así como los LOS Neisseria síntomas y las poblaciones en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum riesgo de infección por H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus .
Patógeno Población en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum riesgo Síntomas
H influenzae Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis
  • Lactantes de 3–18 meses de edad
  • Rara debido a la vacuna
Predominantemente causada por cepas con cápsula tipo B
Otitis media Niños y adultos
  • Precedida por una infección de las vías respiratorias superiores
  • Irritabilidad en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lactantes
  • Otalgia Otalgia Acute Otitis Media
  • Fiebre
Epiglotitis Niños de 2–7 años
  • Epiglotis hinchada, “rojo cereza”
  • Estridor inspiratorio
  • Babeado
Neumonía Ancianos, pacientes con enfermedad pulmonar obstructiva crónica (EPOC) Presentación típica:
esputo teñido de sangre
  • Transmisión: gotitas respiratorias. Los LOS Neisseria seres humanos son el único reservorio de H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus.
  • A pesar del nombre, H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus NO causa influenza Influenza Influenza viruses are members of the Orthomyxoviridae family and the causative organisms of influenza, a highly contagious febrile respiratory disease. There are 3 primary influenza viruses (A, B, and C) and various subtypes, which are classified based on their virulent surface antigens, hemagglutinin (HA) and neuraminidase (NA). Influenza typically presents with a fever, myalgia, headache, and symptoms of an upper respiratory infection. Influenza Viruses/Influenza, la que es exclusivamente viral.
  • Factores de riesgo
    • Edad < 5 años e inmunización H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus tipo b ausente o incompleta
    • Asplenia Asplenia Asplenia is the absence of splenic tissue or function and can stem from several factors ranging from congenital to iatrogenic. There is a distinction between anatomic asplenia, which is due to the surgical removal of the spleen, and functional asplenia, which is due to a condition that leads to splenic atrophy, infarct, congestion, or infiltrative disease. Asplenia funcional o anatómica, incluida la enfermedad de células falciformes
    • Enfermedad subyacente que interfiera con la función del sistema inmunológico
    • Enfermedad estructural del pulmón, tabaquismo, alcoholismo, embarazo, edad avanzada, nivel socioeconómico bajo
  • Diagnóstico
    • Infecciones respiratorias no invasivas: Utilizar signos y síntomas clínicos (otitis media aguda, conjuntivitis, exacerbación de enfermedad pulmonar obstructiva crónica). La detección de H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las vías respiratorias no diferencia la colonización de la infección.
    • Infecciones invasivas: Cultivo (puede carecer de sensibilidad, pero es necesario para comprender la susceptibilidad a antibióticos; es útil una prueba rápida para la producción de betalactamasas), espectrometría de masas MALDI-TOF (desorción/ionización láser asistida por una matriz con detección de masas por tiempo de vuelo), pruebas basadas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum reacción en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cadena de la polimerasa ( PCR PCR Polymerase chain reaction (PCR) is a technique that amplifies DNA fragments exponentially for analysis. The process is highly specific, allowing for the targeting of specific genomic sequences, even with minuscule sample amounts. The PCR cycles multiple times through 3 phases: denaturation of the template DNA, annealing of a specific primer to the individual DNA strands, and synthesis/elongation of new DNA molecules. Polymerase Chain Reaction (PCR))
  • Vacuna solo para la cepa capsular tipo b: disponible desde 1985
    • Vacuna de polisacáridos conjugada con toxoide diftérico (para obtener una mejor respuesta)
    • Administrada a lactantes de 2–6 meses de edad (2 o 3 dosis) con una dosis de refuerzo entre los LOS Neisseria 12 y los LOS Neisseria 15 meses.
    • Incluso después de la vacunación, la infección sigue siendo posible, con un pico de incidencia entre los LOS Neisseria 6 meses y el año, lo que corresponde a una disminución de la inmunoglobulina G ( IgG IgG The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of igg, for example, igg1, igg2a, and igg2b. Hypersensitivity Pneumonitis) protectora materna y la incapacidad del niño para generar suficientes anticuerpos contra el antígeno capsular debido a la inmadurez del sistema inmunológico.
    • Antes de la vacunación, H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus era la principal causa de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana y otras enfermedades invasivas graves en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum niños de < 5 años en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria Estados Unidos; después de la introducción de las vacunas conjugadas contra H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus tipo b en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 1987 y 1989, la incidencia de la enfermedad invasiva por H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus tipo b en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum niños de < 5 años disminuyó en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un 99%.
  • Tratamiento:
    • Infecciones de mucosas: amoxicilina-clavulanato
    • Enfermedad sistémica o meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis: ceftriaxona
    • Profilaxis de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis para los LOS Neisseria contactos cercanos (Si el caso índice tuvo H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus tipo b invasiva o H. infuenzae tipo a): rifampicina
Acute epiglottitis

Radiografía lateral del cuello que muestra epiglotitis y obstrucción completa de las vías respiratorias en una niña de 5 años. Esta afección suele estar causada por la bacteria Haemophilus influenzae.

Imagen: “Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus” por Charuvanij S et al. Licencia: CC BY 2.0

Para ayudar a recordar las manifestaciones clínicas comunes de H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus, usar la siguiente regla mnemotecnia:

  • Ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic AnemiaEMOP hilus Hilus Lungs: Anatomy causa…”
    • E – Epiglotitis
    • M Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis
    • O – Otitis media
    • P Pneumonia Pneumonia Pneumonia or pulmonary inflammation is an acute or chronic inflammation of lung tissue. Causes include infection with bacteria, viruses, or fungi. In more rare cases, pneumonia can also be caused through toxic triggers through inhalation of toxic substances, immunological processes, or in the course of radiotherapy. Pneumonia (neumonía)
Patogenia de Haemophilus influenzae
La especie H. influenzae se divide en cepas tipificables (encapsuladas) y no tipificables, o no encapsuladas. De los 6 serotipos de cepas encapsuladas, H. influenzae tipo b es el tipo más virulento: invade la mucosa respiratoria y se disemina por el torrente sanguíneo para causar enfermedades sistémicas. Las cepas de H. influenzae no encapsuladas por lo general no son invasivas, pero pueden vencer las defensas de las mucosas y causar otitis media, conjuntivitis y bronquitis.
Imagen por Lecturio.

Haemophilus ducreyi

  • La causa del chancroide, una de las 5 clásicas causas infecciosas de úlceras genitales (otras: virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology del Herpes Simple) [HSV-1 y HSV-2]), sífilis [ Treponema pallidum Treponema pallidum The causative agent of venereal and non-venereal syphilis as well as yaws. Treponema], linfogranuloma venéreo [ Chlamydia trachomatis Chlamydia trachomatis Type species of Chlamydia causing a variety of ocular and urogenital diseases. Chlamydia L1-L3], granuloma inguinal [“ donovanosis Donovanosis Donovanosis (also known as granuloma inguinale) is an STD caused by Klebsiella granulomatis and is mainly seen in tropical regions. The condition is characterized by chronic, progressive, ulcerating disease mostly affecting the genital region. Donovanosis”, causada por Klebsiella Klebsiella Klebsiella are encapsulated gram-negative, lactose-fermenting bacilli. They form pink colonies on MacConkey agar due to lactose fermentation. The main virulence factor is a polysaccharide capsule. Klebsiella pneumoniae is the most important pathogenic species. Klebsiella granulomatis])
  • También una de las causas de úlceras cutáneas crónicas no genitales en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum climas tropicales.
  • Presentación clínica del chancroide:
    • Incubación: 3 a 10 días
    • Úlceras: dolorosas, bien circunscritas o irregulares con bordes irregulares y socavados
    • Adenopatía inguinal en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el 50% de los LOS Neisseria casos
    • Los LOS Neisseria hombres son más a menudo sintomáticos que las mujeres.
  • Transmisión: contacto directo
  • Diagnóstico: difícil, por lo que a menudo se utilizan criterios clínicos mientras se excluyen otras causas más probables para llegar a un “diagnóstico probable”
    • Las pruebas de cultivo o PCR PCR Polymerase chain reaction (PCR) is a technique that amplifies DNA fragments exponentially for analysis. The process is highly specific, allowing for the targeting of specific genomic sequences, even with minuscule sample amounts. The PCR cycles multiple times through 3 phases: denaturation of the template DNA, annealing of a specific primer to the individual DNA strands, and synthesis/elongation of new DNA molecules. Polymerase Chain Reaction (PCR) se pueden usar para el diagnóstico, pero no siempre están disponibles.
    • La tinción de Gram puede mostrar pequeños cocobacilos gramnegativos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cadenas que se asemejan a un cardumen o a una vía de tren, pero tiene poca sensibilidad.
  • Tratamiento: ceftriaxona o azitromicina
Haemophilus ducreyi

Bacteria Haemophilus ducreyi, agente causal del chancroide, teñida con violeta de genciana.


Imagen: “Photomicrograph of Haemophilus ducreyi” por CDC Public Health Image Library. Licencia: Dominio Público

Referencias

  1. Briere, E. C., Rubin, L., Moro, P. L., et al. (2014). Prevention and control of Haemophilus influenzae type b disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report (MMWR), 63(RR01), 1-14. https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6301a1.htm?s_cid=rr6301a1_w
  2. CDC. “Clinical Overview of Haemophilus Influenzae Disease.” Haemophilus Influenzae Disease, 21 Aug. 2024, https://www.cdc.gov/hi-disease/hcp/clinicians/index.html.
  3. Langereis, J. D., & de Jonge, M. I. (2015). Invasive disease caused by nontypeable Haemophilus influenzae. Emerging Infectious Diseases, 21(10), 1711-1718. https://doi.org/10.3201/eid2110.150004
  4. Levinson, W., Chin-Hong, P., Joyce, E. A., Nussbaum, J., & Schwartz, B. (2020). In Review of Medical Microbiology and Immunology (16th ed., pp. 166-168, 215-216). McGraw-Hill.
  5. Vermee, Q., Cohen, R., Hays, C., et al. (2019). Biofilm production by Haemophilus influenzae and Streptococcus pneumoniae isolated from the nasopharynx of children with acute otitis media. BMC Infectious Diseases, 19, 44. https://doi.org/10.1186/s12879-018-3657-9

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