Domina Conceptos Médicos

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Diuréticos de Asa

Los LOS Neisseria diuréticos del asa ASA Anterior Cord Syndrome son un grupo de medicamentos diuréticos que se utilizan principalmente para tratar la sobrecarga de volumen en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum condiciones edematosas como la insuficiencia cardíaca y la cirrosis. Los LOS Neisseria diuréticos del asa ASA Anterior Cord Syndrome también tratan la hipertensión, pero no como agente de 1ra línea. El medicamento inhibe la reabsorción de sodio a través del cotransportador NKCC2 NKCC2 Renal Potassium Regulation en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la rama ascendente gruesa del asa ASA Anterior Cord Syndrome de Henle, provocando una diuresis importante. Es importante un monitoreo cuidadoso porque los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome provocan un aumento de la excreción de sodio, potasio, cloro, calcio, magnesio y agua. Además de las anomalías de electrolitos y líquidos, los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome pueden provocar nefrotoxicidad y ototoxicidad.

Last updated: Dec 15, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Descripción General

Definición

Los LOS Neisseria diuréticos del asa ASA Anterior Cord Syndrome son un grupo de medicamentos utilizados principalmente para tratar el edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema (y a veces la hipertensión) mediante la inhibición de la reabsorción de sodio a través del cotransportador NKCC2 NKCC2 Renal Potassium Regulation (también conocido como cotransportador de Na+-K+-Cl) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la rama ascendente gruesa del asa ASA Anterior Cord Syndrome de Henle ( TAL TAL Renal Sodium and Water Regulation), lo que provoca una diuresis significativa.

Resumen de los LOS Neisseria medicamentos antihipertensivos

Tabla: Medicamentos utilizados para tratar la hipertensión
Sitio de acción Clase Subclases
Medicamentos renales Medicamentos que afectan al AL Amyloidosis SRAA
  • IECA
  • Antagonistas de los LOS Neisseria receptores de angiotensina
  • Inhibidores directos de la renina
Diuréticos
Medicamentos extrarrenales Vasodilatadores directos
  • Bloqueadores de los LOS Neisseria canales de calcio
  • Activadores de los LOS Neisseria canales de potasio
  • Nitrodilatadores
  • Antagonistas de la endotelina
Agentes que actúan a través del sistema nervioso simpático
  • Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la vía simpática eferente del SNC (e.g., clonidina)
  • Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria ganglios (e.g., hexametonio)
  • Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las terminales nerviosas (e.g., guanetidina, reserpina)
  • Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria receptores α y β

Medicamentos de la clase de los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome

Los LOS Neisseria medicamentos incluyen:

  • Furosemida (medicamento prototipo de la clase)
  • Bumetanida
  • Torasemida
  • Ácido etacrínico

Estructura Química y Farmacodinamia

Estructura química

  • Todos los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome son sulfonamidas, excepto el ácido etacrínico.
  • El ácido etacrínico puede utilizarse en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum caso de que los LOS Neisseria pacientes sean alérgicos a la furosemida, la bumetanida y/o la torasemida
Estructura química de la furosemida

Estructura química de la furosemida

Imagen: Furosemida por Fvasconcellos. Licencia: Dominio Público

Mecanismo de acción

  • Bloquea la reabsorción de Na+, K+ y Cl mediante la inhibición del cotransportador NKCC2 NKCC2 Renal Potassium Regulation en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la rama ascendente gruesa del asa ASA Anterior Cord Syndrome de Henle.
    • El canal se encuentra en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región apical.
    • Reabsorbe 1 Na+, 1 K+ y 2 Cl del lumen tubular hacia las células
  • Con bloqueo del canal → ↓ reabsorción de Na+
  • El agua siempre sigue al AL Amyloidosis Na+:
    • El agua permanece con el Na+ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria túbulos y no se reabsorbe.
    • El efecto osmótico del Na+ da lugar a la diuresis.
Acción de los diuréticos de asa

Acción de los diuréticos de asa en la rama ascendente gruesa del asa de Henle

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Efectos fisiológicos

  • ↑ Excreción de Na+, K+, Cl por bloqueo del cotransportador NKCC2 NKCC2 Renal Potassium Regulation
  • Diuresis:
    • ↓ Volumen sanguíneo → ↓ precarga cardíaca.
    • Elimina el líquido del cuerpo → mejora el edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
  • Inhibe la capacidad del riñón para diluir o concentrar la orina
  • ↑ Excreción de Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)2+ y Mg2+:
    • El líquido intersticial es relativamente más negativo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum comparación con el lumen tubular.
    • El gradiente electroquímico impulsa la reabsorción pasiva paracelular de Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)2+ y Mg2+.
    • El bloqueo del transportador NKCC2 NKCC2 Renal Potassium Regulation conduce a una ↓ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la reabsorción de Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)2+ y Mg2+ → ↑ excreción de Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)2+ y Mg2+
    • Los LOS Neisseria pacientes tienen un mayor riesgo de hipomagnesemia, hipocalcemia y nefrolitiasis.
Reabsorción paracelular pasiva de magnesio y calcio

Reabsorción paracelular pasiva de magnesio y calcio en la rama ascendente gruesa del asa de Henle: impulsada por el gradiente de voltaje entre el lumen tubular (región apical) y el líquido intersticial (región basolateral)

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Farmacocinética

  • Absorción:
    • La absorción varía según los LOS Neisseria agentes
    • Puede absorberse por vía oral (inicio de acción ligeramente más lento) o por vía intravenosa (más rápido)
    • Biodisponibilidad: bumetanida y torasemida > furosemida
  • Distribución:
    • Muy unido a proteínas → sin filtración renal
    • Excreción renal en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo proximal mediante proteínas de transporte de aniones orgánicos
  • Metabolismo:
    • Bumetanida y torasemida: se inactivan principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hígado por el citocromo P450 (CYP450)
    • Furosemida: metabolismo hepático mínimo
  • Excreción:
    • Se excreta mayormente por vía renal como medicamento inalterado
    • Rango de vida media: 1–4 horas
Tabla: Farmacocinética de los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome
Medicamento Absorción Distribución Metabolismo Excreción
Furosemida ( Lasix Lasix A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. Loop Diuretics®)
  • Efecto máximo:
    • Oral: 1–2 horas
    • Intravenoso: 30 minutos
  • Biodisponibilidad: 50%.
Unión a proteínas: 95% Metabolismo hepático mínimo
  • Orina (poca excreción fecal)
  • Vida media:
    • Función renal normal: 0,5–2 horas
    • Enfermedad renal en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum etapa terminal: 9 horas
Bumetanida ( Bumex Bumex A sulfamyl diuretic. Loop Diuretics®)
  • Efecto máximo:
    • Oral: 1-2 horas
    • Intravenoso: 30 minutos
  • Biodisponibilidad: 60%–90%.
  • Vd: 9–25 L
  • Unión a proteínas: 95%
Metabolismo hepático parcial
  • Orina
  • Heces (2%)
  • Vida media: 60-90 minutos
Torasemida ( Demadex Demadex A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of edema associated with congestive heart failure; chronic renal insufficiency; and liver diseases. It is also used for the management of hypertension. Loop Diuretics®)
  • Efecto máximo: 1-2 horas
  • Biodisponibilidad: 80%.
  • Vd: 12–15 L
  • Unión a proteínas: > 99%
Hepático (80%) vía CYP2C9 CYP2C9 A cytochrome p-450 subtype that has specificity for acidic xenobiotics. It oxidizes a broad range of important clinical drugs that fall under the categories of nonsteroidal anti-inflammatory agents; hypoglycemic agents; anticoagulants; and diuretics. Anticoagulants
  • Orina
  • Vida media: 3,5 horas
Ácido etacrínico ( Edecrin Edecrin A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. Loop Diuretics®) Efecto máximo:
  • Oral: 2 horas
  • Intravenoso: 30 minutos
Unión a proteínas: > 90% Hepático (40%) a través de la vía cisteína conjugada activada
  • Heces y orina
  • Vida media: 2–4 horas

Indicaciones, Contraindicaciones y Efectos Adversos

Indicaciones

  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema:
    • Incluye:
      • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema periférico
      • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema pulmonar
      • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema generalizado
      • Ascitis
    • Resultante de:
      • Insuficiencia cardíaca (utilizada para el tratamiento sintomático; no hay beneficio en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cuanto a la mortalidad)
      • Enfermedad hepática/cirrosis
      • Enfermedad renal, incluido el síndrome nefrótico
  • Hipertensión:
    • No son agentes de 1ra línea
    • Normalmente se utiliza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con otros agentes
    • Se utiliza con mayor frecuencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con insuficiencia cardíaca e hipertensión que presentan sobrecarga de líquidos

Contraindicaciones

  • Anuria Anuria Absence of urine formation. It is usually associated with complete bilateral ureteral (ureter) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present. Acute Kidney Injury
  • Alergia a las sulfamidas (excepto al AL Amyloidosis ácido etacrínico)
  • Coma Coma Coma is defined as a deep state of unarousable unresponsiveness, characterized by a score of 3 points on the GCS. A comatose state can be caused by a multitude of conditions, making the precise epidemiology and prognosis of coma difficult to determine. Coma hepático
  • Depleción electrolítica severa
  • Ácido etacrínico en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lactantes

Efectos adversos significativos y toxicidad

  • Nefrotoxicidad
  • Ototoxicidad
  • Pérdida de líquidos y electrolitos, que pueden predisponer a:
    • Arritmias cardíacas
    • Hipotensión ortostática
    • Deshidratación
    • Mareo/vértigo/síncope
    • Cefaleas
    • Síntomas gastrointestinales (cólicos abdominales, náuseas, estreñimiento, diarrea)
    • Calambres musculares
  • Fotosensibilidad

Mnemotecnia:

Para no olvidar los LOS Neisseria efectos adversos de los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome, recordar Ohh Daang ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés):

  • O Ototoxicity Ototoxicity Damage to the ear or its function secondary to exposure to toxic substances such as drugs used in chemotherapy; immunotherapy; or radiation. Glycopeptides (ototoxicidad)
  • H Hypokalemia Hypokalemia Hypokalemia is defined as plasma potassium (K+) concentration < 3.5 mEq/L. Homeostatic mechanisms maintain plasma concentration between 3.5-5.2 mEq/L despite marked variation in dietary intake. Hypokalemia can be due to renal losses, GI losses, transcellular shifts, or poor dietary intake. Hypokalemia (hipopotasemia)
  • H Hypomagnesemia Hypomagnesemia A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. Electrolytes (hipomagnesemia)
  • D Dehydration Dehydration The condition that results from excessive loss of water from a living organism. Volume Depletion and Dehydration (deshidratación)
  • A Allergy Allergy An abnormal adaptive immune response that may or may not involve antigen-specific IgE Type I Hypersensitivity Reaction (alergia a sulfa)
  • A Alkalosis Alkalosis A pathological condition that removes acid or adds base to the body fluids. Respiratory Alkalosis (alcalosis metabólica)
  • N – Nephritis (nefritis intersticial)
  • G Gout Gout Gout is a heterogeneous metabolic disease associated with elevated serum uric acid levels (> 6.8 mg/dL) and abnormal deposits of monosodium urate in tissues. The condition is often familial and is initially characterized by painful, recurring, and usually monoarticular acute arthritis, or “gout flare,” followed later by chronic deforming arthritis. Gout (gota)

Precauciones

Los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome deben utilizarse con precaución en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las siguientes situaciones:

  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum anomalías electrolíticas, de fluidos o ácido-base, los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome pueden causar:
    • Hipopotasemia (↓ K+)
    • Hiponatremia (↓ Na+)
    • Hipocalcemia (↓ Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)2+) (las tiazidas tienden a causar hipercalcemia)
    • Hipomagnesemia (↓ Mg2+)
    • Alcalosis metabólica
    • Azotemia Azotemia A biochemical abnormality referring to an elevation of blood urea nitrogen and creatinine. Azotemia can be produced by kidney diseases or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed uremia. Acute Kidney Injury prerrenal
    • Hipovolemia
  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con otros medicamentos que aumentan el riesgo de hipopotasemia:
    • Corticosteroides
    • Ciertos medicamentos antipsicóticos
    • Amfotericina B
  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con otros medicamentos que aumentan el riesgo de nefrotoxicidad y/u ototoxicidad:
    • Aminoglucósidos
    • Probenecid Probenecid The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. Gout Drugs
  • Ciertas condiciones médicas:
    • Hiperuricemia/gota (puede precipitar la gota)
    • Lupus eritematoso sistémico (LES) (puede provocar un brote)
    • Enfermedad renal y/o hepática
    • Prolongación del QT (puede agravarse como consecuencia de la hipopotasemia inducida por los LOS Neisseria diuréticos)
    • Embarazo y lactancia

Comparación de Medicamentos

Los LOS Neisseria diuréticos tiazídicos, los LOS Neisseria diuréticos ahorradores de potasio, los LOS Neisseria inhibidores de la anhidrasa carbónica y los LOS Neisseria diuréticos osmóticos también son diuréticos comunes.

Tabla: Comparación de los LOS Neisseria diuréticos
Medicamento Mecanismo Efecto fisiológico Indicación
Diurético tiazídico: Hidroclorotiazida ↓ Reabsorción de NaCl en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo contorneado distal a través de la inhibición del cotransportador de Na+/Cl.
  • ↓ Presión arterial
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
  • Hipertensión
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
Diurético de asa ASA Anterior Cord Syndrome: Furosemida Inhibe el cotransportador luminal de Na+/K+/Cl en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la rama ascendente gruesa del asa ASA Anterior Cord Syndrome de Henle
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
  • ↓ Presión arterial
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema/ascitis
  • ICC
  • Hipertensión
Diurético ahorrador de potasio: Espironolactona
  • ↓ Reabsorción de Na a través de los LOS Neisseria canales ENaC ENaC Sodium channels found on salt-reabsorbing epithelial cells that line the distal nephron; the distal colon; salivary ducts; sweat glands; and the lung. They are amiloride-sensitive and play a critical role in the control of sodium balance, blood volume, and blood pressure. Liddle Syndrome en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo colector
  • Inhibición de los LOS Neisseria receptores de aldosterona en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo colector
  • ↓ Presión arterial
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
  • No causa ↑ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la excreción de K+
  • Efectos antiandrogénicos
  • ICC
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema/ascitis
  • Hipertensión
  • Hirsutismo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las mujeres
  • Hiperaldosteronismo primario
Inhibidor de la anhidrasa carbónica: Acetazolamida Inhibe tanto la hidratación del CO2 en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células epiteliales del túbulo contorneado proximal como la deshidratación del H2CO3 en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el lumen del túbulo contorneado proximal; provoca una excreción ↑ HCO3 y Na+.
  • ↑ Excreción urinaria de HCO3 acidosis Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are respiratory acidosis and metabolic acidosis, due to metabolic acid build up. Respiratory Acidosis metabólica.
  • ↓ Presión intraocular
  • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con alcalosis metabólica
  • Enfermedad de las alturas
  • ↑ Presión intraocular
  • Uso fuera de indicación: hidrocefalia de presión normal
Diuréticos osmóticos: Manitol ↑ Presión osmótica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el filtrado glomerular → ↑ líquido tubular e impide la reabsorción de agua.
  • ↓ Agua libre
  • ↓ Volumen sanguíneo cerebral
  • Aumento de la presión intracraneal
  • Aumento de la presión intraocular


ICC: insuficiencia cardíaca
Diuréticos

Sitios de acción, dentro de la nefrona, para las clases de medicamentos diuréticos

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Referencias

  1. The American Society of Health-System Pharmacists. (2025). Furosemide. Retrieved January 27, 2025, from https://www.drugs.com/monograph/furosemide.html#
  2.  Fischer, J., Ganellin, C.R. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458.
  3. World Health Organization. (2019). World Health Organization model list of essential medicines: 21st list 2019. http://apps.who.int/iris/handle/10665/325771
  4. Kane, S.P. (2022). Furosemide. Retrieved January 27, 2025, from https://clincalc.com/DrugStats/Drugs/Furosemide
  5. King, K.C. Goldstein, S. (2022). Congestive Heart Failure And Pulmonary Edema. StatPearls, Treasure Island (FL): StatPearls Publishing. Retrieved January 27, 2025, from https://pubmed.ncbi.nlm.nih.gov/32119444/
  6. Felker, G.M., et al. (2011). Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 364(9), 797–805. https://pubmed.ncbi.nlm.nih.gov/21366472/
  7. James, P.A., et al. (2014). 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 311(5), 507–520. https://pubmed.ncbi.nlm.nih.gov/24352797/
  8. Whelton, P.K., et al. (2018). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 71(6), e13–e115. https://pubmed.ncbi.nlm.nih.gov/29133356/
  9. Kidney Disease Outcomes Quality Initiative (K/DOQI). (2004). K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease. Am J Kidney Dis. 43(5 Suppl 1), S1–290. https://pubmed.ncbi.nlm.nih.gov/15114537/
  10. Runyon, B.A. (2013). Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012. Hepatology. 57(4), 1651–1653. https://pubmed.ncbi.nlm.nih.gov/23463403/
  11. Shankar, S.S., Brater, D.C. (2003). Loop diuretics: from the Na-K-2Cl transporter to clinical use. Am J Physiol Renal Physiol. 284(1), F11–21. https://pubmed.ncbi.nlm.nih.gov/12473535/
  12. Brater, D.C., et al. (1983). Bumetanide and furosemide. Clin Pharmacol Ther. 34(2), 207–213. https://pubmed.ncbi.nlm.nih.gov/6872415/
  13. Ponto, L.L., Schoenwald, R.D. (1990). Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). Clin Pharmacokinet. 18(5), 381–408. https://pubmed.ncbi.nlm.nih.gov/2185908/
  14. Hammarlund, M.M., et al. (1984). Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis. Eur J Clin Pharmacol. 26(2), 197–207. https://pubmed.ncbi.nlm.nih.gov/6723758/
  15. Mann, J.F. (2024). Choice of drug therapy in primary (essential) hypertension. In Forman, J.P. (Ed.), UpToDate. Retrieved January 27, 2025, from https://www.uptodate.com/contents/choice-of-drug-therapy-in-primary-essential-hypertension 
  16. Brater, D.C., Ellison, D.H. (2025). Loop diuretics: Dosing and major side effects. In Forman, J.P. (Ed.), UpToDate. Retrieved January 27, 2025, from https://www.uptodate.com/contents/loop-diuretics-dosing-and-major-side-effects
  17. UpToDate Lexicomp Drug Topic Pages. Furosemide. Retrieved January 27, 2025, from https://www.uptodate.com/contents/furosemide-drug-information
  18. UpToDate Lexicomp Drug Topic Pages. Bumetanide. Retrieved January 27, 2025, from https://www.uptodate.com/contents/bumetanide-drug-information
  19. UpToDate Lexicomp Drug Topic Pages. Torsemide. Retrieved January 27, 2025, from https://www.uptodate.com/contents/torsemide-torasemide-drug-information
  20. UpToDate Lexicomp Drug Topic Pages. Ethacrynic acid. Retrieved January 27, 2025, from https://www.uptodate.com/contents/ethacrynic-acid-drug-information
  21. Huxel, C. (2023). Loop Diuretics. StatPearls. Retrieved January 27, 2025, from https://www.statpearls.com/articlelibrary/viewarticle/24416/

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