Antivirales para el Virus de la Hepatitis C

Descripción General

Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus ( HCV HCV Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). Hepatitis C virus is an RNA virus and a member of the genus Hepacivirus and the family Flaviviridae. The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C Virus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)

• Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de ARN monocatenario
• Familia: Flaviviridae Flaviviridae A family of RNA viruses, many of which cause disease in humans and domestic animals. There are three genera flavivirus; pestivirus; and hepacivirus, as well as several unassigned species. Hepatitis C Virus
• Transmitido por:
  • Vía parenteral
    • Sangre y hemoderivados
    • Uso de drogas intravenosas
  • Vía perinatal (transmisión horizontal)
  • Relaciones sexuales
• La infección puede conducir a:
  • Hepatitis aguda y crónica
  • Cirrosis
  • Carcinoma hepatocelular

Proteínas virales

El ARN del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus codifica:

• 3 proteínas estructurales:
  • Núcleo (contiene ARN viral)
  • Envoltura 1 ( E1 E1 An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Noncontraceptive Estrogen and Progestins) y envoltura 2 (E2) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la envoltura lipídica
• 6 proteínas no estructurales (NS) (NS2, NS3, NS4A, NS4B, NS5A y NS5B)
  • Importantes para la adhesión y replicación viral, traducción y procesamiento del ARN, así como su ensamblaje y liberación
  • Blancos de los LOS Neisseria nuevos agentes antivirales

Regímenes de tratamiento

• Infección aguda: previamente con interferón alfa (IFN-α) y ribavirina:
  • Las recomendaciones actuales son similares a las de la infección crónica por HCV HCV Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). Hepatitis C virus is an RNA virus and a member of the genus Hepacivirus and the family Flaviviridae. The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C Virus sin tratamiento (régimen de antivirales de acción directa).
  • Cuando se detecta viremia Viremia The presence of viruses in the blood. Erythema Infectiosum, se recomienda un régimen pangenotípico.
  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algunos lugares donde no se dispone de tratamiento sin interferón, se sigue utilizando el IFN-ɑ.
• Infección crónica:
  • Depende del genotipo, presencia de cirrosis, y si se ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia administrado tratamiento previo
  • Tratamientos utilizados anteriormente:
    • IFN-α
    • Ribavirina
  • Ahora reemplazados con antivirales de acción directa:
    • Inhibidores de la proteasa NS3/4A
    • Inhibidores de NS5A
    • Inhibidores de la polimerasa de ARN NS5B
  • Los LOS Neisseria antivirales de acción directa generalmente se administran como una terapia combinada.
    • > 90% de tasa de éxito
    • Sin efectos secundarios significativos

IFN-α

Estructura química

Los LOS Neisseria interferones son un tipo de proteína de señalización perteneciente a la familia de las citoquinas.

Mecanismo de acción

IFN-α funciona a través de varios mecanismos:

• Induce señales intracelulares responsables de la inhibición viral:
  • Entrada en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum una célula
  • Procesamiento de proteínas
  • Replicación
• Modula el sistema inmunológico:
  • ↑ Expresión de moléculas del CMH
  • ↑ Actividad fagocítica
  • ↑ Supervivencia, proliferación y actividad de linfocitos T CD8+ citotóxicas y linfocitos asesinas naturales → lisis de células infectadas

Farmacocinética

• Absorción:
  • Disponible en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum formas intramuscular y subcutánea
  • Mala biodisponibilidad oral
  • La absorción es lenta.
• Metabolismo: sufre proteólisis por proteasas endógenas
• Excreción: renal y biliar

Indicaciones

• Hepatitis:
  • Hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus crónica
  • Hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus
    • Aguda
    • Crónica ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con ribavirina)
  • Hepatitis crónica D
  • Hepatitis crónica E
• Neoplasias malignas, tales como:
  • Linfoma no Hodgkin
  • Melanoma Melanoma Melanoma is a malignant tumor arising from melanocytes, the melanin-producing cells of the epidermis. These tumors are most common in fair-skinned individuals with a history of excessive sun exposure and sunburns. Melanoma maligno
  • Leucemia de células peludas
  • Sarcoma de Kaposi Kaposi A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Hhv-8 is the suspected cause. There is also a high incidence in AIDS patients. AIDS-defining Conditions
  • Condiloma acuminado
  • Linfoma folicular
• Otras condiciones hematológicas:
  • Policitemia vera
  • Trombocitopenia esencial

Efectos secundarios

• Síndrome pseudogripal
  • Cefalea
  • Fiebre y escalofríos
  • Mialgia
  • Malestar
• ↑ Transitorio de las enzimas hepáticas después de 8–10 semanas de tratamiento
• En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum terapia prolongada:
  • Efectos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el SNC
    • Trastornos del estado de ánimo
    • Convulsiones
    • Confusión
    • Pensamientos suicidas
  • Mielosupresión
    • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia
    • Trombocitopenia
    • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
  • Inducción de autoanticuerpos y enfermedad autoinmune
  • Infección bacterial/viral/fúngica severa
  • Condiciones isquémicas y hemorrágicas

Contraindicaciones

• Enfermedad hepática descompensada
• Enfermedades autoinmunes
• Antecedente previo de arritmia cardíaca
• Trastorno convulsivo no controlado
• Embarazo

Interacciones farmacológicas

• ↑ Niveles séricos de:
  • Metadona
  • Teofilina
• ↑ Riesgo de insuficiencia hepática → didanosina
• ↑ Riesgo de mielosupresión con:
  • Zidovudina
  • Clozapina

Ribavirina

Estructura química

• Análoga de guanosina
• Promedicamento → metabolizado en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum forma activa dentro de las células

Mecanismo de acción

• Se asemeja a la guanosina → interfiere con la síntesis de trifosfato de guanosina (GTP)
• Inhibe la polimerasa dependiente de ARN viral de algunos virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology
• Resulta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la inhibición de:
  • Replicación viral (ADN y ARN)
  • Síntesis de proteínas virales

Farmacocinética

• Absorción:
  • Rápidamente absorbida
  • Biodisponibilidad:
    • ↑ Con comidas ricas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum grasas
    • ↓ Con antiácidos
• Distribución:
  • Gran volumen de distribución
  • No unida a proteínas
• Metabolismo: hepático e intracelular (formando metabolitos activos)
• Excreción:
  • Orina (principalmente)
  • Heces

Indicaciones

• Hepatitis viral:
  • Hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus crónica
  • Hepatitis E Hepatitis E Acute inflammation of the liver in humans; caused by hepatitis E virus, a non-enveloped single-stranded RNA virus. Similar to hepatitis a, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission. Hepatitis E Virus crónica
• Infección por virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology sincitial respiratorio ( RSV RSV Respiratory syncytial virus (RSV) is an enveloped, single-stranded, linear, negative-sense RNA virus of the family Paramyxoviridae and the genus Orthopneumovirus. Two subtypes (A and B) are present in outbreaks, but type A causes more severe disease. Respiratory syncytial virus causes infections of the lungs and respiratory tract. Respiratory Syncytial Virus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)
• Fiebres hemorrágicas virales específicas (como la fiebre de Lassa)

Efectos secundarios

• Prurito
• Malestar gastrointestinal
• Depresión
• Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica (dependiente de dosis)

Contraindicaciones

• Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
• Enfermedad cardiovascular significativa (potencial anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types grave → isquemia miocárdica)
• Insuficiencia renal grave
• Embarazo (teratogénico)

Interacciones farmacológicas

• ↑ Riesgo de toxicidad mitocondrial: didanosina
• Mielosupresión
  • Azatioprina
  • Zidovudina (particularmente anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types)

Inhibidores de la Proteasa NS3/4A

Medicamentos de esta clase

• Simeprevir Simeprevir Oral hcv-protease inhibitor effective against hepatitis C virus (hcv) serine protease ns3/4a. It is used in the treatment of chronic hepatitis C (antivirals) genotype 1 infection in adults with compensated liver disease, including cirrhosis. Antivirals for Hepatitis C (descontinuado en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos)
• Glecaprevir Glecaprevir Antivirals for Hepatitis C
• Grazoprevir Grazoprevir Antivirals for Hepatitis C
• Paritaprevir Paritaprevir Antivirals for Hepatitis C
• Voxilaprevir Voxilaprevir Antivirals for Hepatitis C

Mecanismo de acción

Los LOS Neisseria inhibidores de la proteasa NS3/4A son una clase de medicamento que inhibe la serina proteasa NS3/4A, que es necesaria para la replicación del HCV HCV Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). Hepatitis C virus is an RNA virus and a member of the genus Hepacivirus and the family Flaviviridae. The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C Virus.

Farmacocinética

• Distribución: unidos a proteínas
• Metabolizados: enzimas del citocromo P450 (CYP) (principalmente CYP3A)
• Excreción: principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum heces

Indicaciones

Los LOS Neisseria inhibidores de la proteasa NS3/4A se usan (generalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum terapia combinada con otro antiviral Antiviral Antivirals for Hepatitis B de acción directa) para tratar la hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus crónica.

Efectos secundarios

• Náuseas
• Cefalea
• Fatiga
• Diarrea
• Erupciones y fotosensibilidad
• Descompensación hepática
• Reactivación de hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus (prueba para el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus antes del tratamiento para HCV HCV Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). Hepatitis C virus is an RNA virus and a member of the genus Hepacivirus and the family Flaviviridae. The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C Virus)

Interacciones farmacológicas

• Puede aumentar el efecto hipoglicemiante de los LOS Neisseria medicamentos antidiabéticos
• ↑ Concentraciones séricas de algunas estatinas
• Inductores e inhibidores de CYP3A4 CYP3A4 Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers) → alteran los LOS Neisseria niveles de inhibidores de la proteasa NS3/4A

Inhibidores de NS5A

Medicamentos de esta clase

• Daclatasvir Daclatasvir Antivirals for Hepatitis C (descontinuado en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos)
• Ledipasvir Ledipasvir Antivirals for Hepatitis C
• Velpatasvir Velpatasvir Antivirals for Hepatitis C
• Elbasvir Elbasvir Antivirals for Hepatitis C
• Ombitasvir Ombitasvir Antivirals for Hepatitis C
• Pibrentasvir Pibrentasvir Antivirals for Hepatitis C

Mecanismo de acción

• El mecanismo exacto no está claro.
• Se unen a NS5A → inhiben la replicación viral

Farmacocinética

• Absorción: generalmente bien absorbidos
• Distribución: unidos a proteínas
• Metabolismo: la mayoría son metabolizados por el sistema CYP (a menudo CYP3A4 CYP3A4 Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers)).
• Eliminación: principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum heces

Indicaciones

Estos medicamentos se usan (generalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum terapia combinada con otro antiviral Antiviral Antivirals for Hepatitis B de acción directa) para el tratamiento de la hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus crónica.

Efectos secundarios

• Cefalea
• Fatiga
• Náuseas
• Descompensación hepática
• Reactivación de hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus (prueba para el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus antes del tratamiento para HCV HCV Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). Hepatitis C virus is an RNA virus and a member of the genus Hepacivirus and the family Flaviviridae. The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C Virus)

Interacciones farmacológicas

• Puede aumentar el efecto hipoglicemiante de los LOS Neisseria medicamentos antidiabéticos
• ↑ Concentraciones séricas de algunas estatinas
• Inductores e inhibidores de CYP3A4 CYP3A4 Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers) → alteran los LOS Neisseria niveles de inhibidores de NS5A

Inhibidores de la ARN Polimerasa NS5B Dependientes de ARN

Clasificación

• Inhibidores nucleósidos/nucleótidos de la polimerasa: sofosbuvir
• Inhibidores no nucleósidos de la polimerasa: dasabuvir

Mecanismo de acción

Los LOS Neisseria inhibidores de la ARN polimerasa NS5B dependiente de ARN se enfocan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum NS5B (una polimerasa de ARN dependiente de ARN).

• Los LOS Neisseria inhibidores nucleósidos/nucleótidos de la polimerasa son activados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria hepatocitos → compiten con los LOS Neisseria nucleótidos y se incorporan al AL Amyloidosis ARN viral → no se pueden agregar nuevos nucleótidos → se detiene la replicación viral
• Inhibidores no nucleósidos de la polimerasa se unen alostéricamente a NS5B → ↓ función polimerasa → inhiben la replicación viral

Farmacocinética

• Distribución: unidos a proteínas
• Metabolismo:
  • Inhibidores nucleósidos/nucleótidos de la polimerasa fosforilados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum hepatocitos → forma activa
  • Dasabuvir: CYP2C8 CYP2C8 A liver microsomal cytochrome p450 hydroxylase that oxidizes a broad spectrum of substrates including steroids, fatty acids, and xenobiotics. Examples of pharmaceutical substrates for cyp2c8 include; paclitaxol; torsemide; and; amodiaquine. Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers) y CYP3A
• Excreción:
  • Sofosbuvir: principalmente orina
  • Dasabuvir: principalmente heces

Indicaciones

Los LOS Neisseria inhibidores de la ARN polimerasa NS5B dependientes de ARN se usan (generalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum terapia combinada con otro antiviral Antiviral Antivirals for Hepatitis B de acción directa) para el tratamiento de la hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus crónica.

Efectos secundarios

• Fatiga
• Cefalea
• Insomnio
• Náuseas
• Pueden reactivar la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus

Interacciones farmacológicas

• Pueden aumentar el efecto hipoglicemiante de los LOS Neisseria medicamentos antidiabéticos
• ↑ Concentraciones séricas de algunas estatinas
• Amiodarona → ↑ bradicardia (con sofosbuvir)