Domina Conceptos Médicos

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Virus de la Rubéola

La rubéola (también conocida como sarampión alemán o sarampión de tres días) es causada por un virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de ARN monocatenario de sentido positivo de la familia Matonaviridae y del género Rubivirus Rubivirus A genus of the family togaviridae containing only one recognized species, rubella virus. Transmission is primarily by aerosolization. Rubella Virus. La rubéola solo infecta a los LOS Neisseria humanos y se propaga prenatalmente a través de transmisión vertical o posnatalmente a través del contacto con gotitas. La rubéola congénita es particularmente devastadora y se asocia con una tríada clásica de síntomas: cataratas, defectos cardiacos y sordera. La infección en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum niños y adultos puede ser leve y presentarse con síntomas constitucionales junto con un exantema viral parecido al AL Amyloidosis virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology del sarampión. El diagnóstico se realiza clínicamente y se confirma con la detección del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum suero y estudios serológicos. El tratamiento es de apoyo y puede dirigirse según el sistema de órganos involucrado. La prevención se logra mediante la vacunación infantil con la vacuna contra el sarampión, las paperas y la rubéola (SPR).

Last updated: Dec 15, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Clasificación

Diagrama de flujo de la clasificación de los virus de ARN

Identificación de los virus ARN:
Los virus pueden clasificarse de muchas maneras. Sin embargo, la mayoría de los virus tienen un genoma formado por ADN o ARN. Los virus con genoma ARN pueden caracterizarse además por tener ARN monocatenario o bicatenario. Los virus “envueltos” están cubiertos por una fina capa de membrana celular (normalmente tomada de la célula huésped). Si la capa está ausente, los virus se denominan “desnudos”. Los virus con genomas monocatenarios son positivos si el genoma se emplea directamente como ARN mensajero (ARNm), que se traduce en proteínas. Los virus monocatenarios negativos emplean la ARN polimerasa, una enzima viral, para transcribir su genoma en ARNm.

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Características Generales

Serovares, linajes y cepas:

  • Familia Matonaviridae: La rubéola es el único matonavirus que utiliza a los LOS Neisseria seres humanos como único huésped natural.
  • Género Rubivirus Rubivirus A genus of the family togaviridae containing only one recognized species, rubella virus. Transmission is primarily by aerosolization. Rubella Virus: El virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la rubéola es el único miembro del género Rubivirus Rubivirus A genus of the family togaviridae containing only one recognized species, rubella virus. Transmission is primarily by aerosolization. Rubella Virus.
  • Serovar:
    • Un serovar se define por el número y tipo de antígenos de superficie que posee un microorganismo.
    • Solo se ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia identificado un serovar de rubéola genéticamente estable.
  • Linaje:
    • Un linaje es una colección de variantes definidas por mutaciones nuevas que delinean una línea genética específica del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology.
    • Han surgido al AL Amyloidosis menos 3 linajes distintos a partir de un solo serovar de rubéola.
  • Cepa:
    • Una cepa es un linaje que adquiere nuevas propiedades como resultado de las mutaciones que definen el linaje.
    • Varias cepas del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la rubéola se caracterizan por diferentes antigenicidades, que son la capacidad de los LOS Neisseria antígenos para unirse a los LOS Neisseria receptores de antígenos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un anticuerpo o linfocito T.

Virión de rubéola

Estructura:

  • Esférico
  • 40 a 80 nm de diámetro
  • La envoltura de lipoproteínas contiene 2 glicoproteínas de membrana formadoras de picos:
    • E1 E1 An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Noncontraceptive Estrogen and Progestins media la hemaglutinación y neutralización viral.
    • E2 tiene 2 subtipos:
      • E2a y E2b
      • Las variaciones de la glicoproteína E2 confieren las diferencias entre las cepas de rubéola.
    • Los LOS Neisseria picos también contienen epítopos de hemaglutinina, que hacen que los LOS Neisseria glóbulos rojos se agrupen (hemaglutinación).
  • Un núcleo denso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum electrones de 30 a 35 nm:
    • ARN monocatenario de sentido positivo
    • La proteína C de la cápside rodea al AL Amyloidosis ARN.

Genoma de la rubéola

  • Solo se ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia identificado un solo serovar de rubéola estable.
  • Muy poca variación entre las cepas del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la rubéola
  • Sugiere una baja tasa de mutación durante la replicación viral.
  • Las cepas se identifican fácilmente a nivel mundial, lo que sugiere una constante cocirculación de linajes.
Micrografía electrónica del virus de la rubéola

Micrografía electrónica de viriones del virus de la rubéola

Imagen: “This transmission electron microscopic (TEM) image revealed the presence of rubella virus virions” por CDC. Licencia: Public Domain

Epidemiología y Patogénesis

Epidemiología

  • 1964–1965: En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos se registraron más de 12 millones de casos de rubéola y 20.000 casos de rubéola congénita.
  • 1969: Se introdujo la vacuna en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos → los LOS Neisseria casos se redujeron a 0,5 casos cada 100.000.
  • 1990–1991: resurgimiento de brotes en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum California y Pensilvania
  • 2004: rubéola eliminada de Estados Unidos debido a la vacuna contra el sarampión, las paperas y la rubéola (SPRV)
  • 2018: 14.621 casos a nivel mundial
  • 2019: 168 países con programas de vacunación establecidos

Transmisión

  • Gotitas respiratorias:
    • Contacto directo o por gotitas con secreciones respiratorias de pacientes infectados
    • El virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology se replica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células del tracto respiratorio.
    • La diseminación viral del tracto respiratorio puede continuar hasta 6 semanas después de la infección inicial.
    • Infectividad y virulencia relativamente bajas
  • Vertical (madre a hijo):
    • Durante los LOS Neisseria primeros 3–4 meses de embarazo como una de las infecciones TORCH ( toxoplasmosis Toxoplasmosis Toxoplasmosis is an infectious disease caused by Toxoplasma gondii, an obligate intracellular protozoan parasite. Felines are the definitive host, but transmission to humans can occur through contact with cat feces or the consumption of contaminated foods. The clinical presentation and complications depend on the host’s immune status. Toxoplasma/Toxoplasmosis, otros agentes, rubéola, citomegalovirus, herpes simple):
      • Las infecciones TORCH también pueden incluir el VIH o la sífilis.
      • Constituyen las infecciones más comunes que se propagan por transmisión vertical.
    • Puede ocurrir durante la lactancia.

Patogénesis

Prenatal:

  • Viremia Viremia The presence of viruses in the blood. Erythema Infectiosum directa por transmisión placentaria
  • El resultado depende de la edad gestacional y probablemente se deba a la de las defensas inmaduras del feto.
  • El riesgo de infección y defectos congénitos asociados disminuye con la edad gestacional:
    • 40%–60% de probabilidad si la madre se infecta durante los LOS Neisseria primeros 2 meses de gestación.
    • 30%–35% de probabilidad durante el tercer mes de gestación
    • 10% de probabilidad durante el cuarto mes de gestación
  • Los LOS Neisseria viriones pueden afectar prácticamente a cualquier sistema de órganos fetales.

Posnatal:

Las infecciones primarias posnatales con rubéola se someten a un proceso patogénico secuencial:

  1. Inoculación a través del tracto respiratorio
  2. Adhesión a las membranas de las células del tracto respiratorio (la entrada del virión en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la célula huésped se produce mediante el transporte al AL Amyloidosis interior de los LOS Neisseria endosomas)
  3. Multiplicación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el citoplasma de la célula huésped durante 2–3 semanas
  4. Exocitosis a través de un mecanismo poco claro
  5. Infiltración de los LOS Neisseria ganglios linfáticos locales, lo que provoca síntomas constitucionales y linfadenopatía
  6. Desarrollo de viremia Viremia The presence of viruses in the blood. Erythema Infectiosum (el virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology se detecta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la sangre y las secreciones respiratorias)
  7. Multiplicación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células de otros órganos
  8. Desarrollo de fiebre y erupción (anticuerpos IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions específicos de rubéola detectados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la sangre)
  9. Antes de la resolución de la erupción, desaparición del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology detectable en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la sangre a medida que aumentan los LOS Neisseria anticuerpos
  10. Los LOS Neisseria anticuerpos IgG IgG The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of igg, for example, igg1, igg2a, and igg2b. Hypersensitivity Pneumonitis confieren inmunidad futura, pero puede ocurrir una reinfección.

Presentación Clínica

Rubéola congénita

  • Síndrome de rubéola congénita con la tríada clásica:
    • Cataratas
    • Defectos cardiacos
    • Sordera
  • Infección congénita de rubéola (término más amplio para abarcar todos los LOS Neisseria posibles signos y síntomas de infección):
    • Ocular: cataratas, microftalmia, glaucoma Glaucoma Glaucoma is an optic neuropathy characterized by typical visual field defects and optic nerve atrophy seen as optic disc cupping on examination. The acute form of glaucoma is a medical emergency. Glaucoma is often, but not always, caused by increased intraocular pressure (IOP). Glaucoma y retinitis
    • Cardiovascular: conducto arterioso persistente, comunicación interauricular, comunicación interventricular y estenosis de la arteria pulmonar
    • Sistema nervioso central: discapacidad intelectual, meningoencefalitis, microcefalia y panencefalitis progresiva por rubéola (raro)
    • Otros: retraso del crecimiento, enfermedad ósea radiolúcida, hepatoesplenomegalia, trombocitopenia, neumonitis, diabetes mellitus, tiroiditis, petequias y púrpura (una “erupción de muffin de arándanos” debido a hematopoyesis extramedular en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la piel)

Rubéola posnatal

  • Periodo de incubación de 2 a 3 semanas ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum última instancia, puede ser asintomático (50% de los LOS Neisseria casos))
  • Síntomas:
    • 1–2 semanas después de la exposición: cefalea, malestar, mialgias, linfadenopatía, mialgias y artralgias
    • Hasta 1 semana después de los LOS Neisseria síntomas iniciales:
      • Fiebre y erupción maculopapular Maculopapular Dermatologic Examination
      • Exantema: Comienza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cara y cuello, se extiende caudalmente.
      • Se asemeja al AL Amyloidosis exantema del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology del sarampión.
Exantema de la infección por el virus de la rubéola

Exantema típico de la infección por rubéola:
La propagación y la distribución son similares a las del sarampión; sin embargo, las lesiones son menos roji-intensas y menos confluentes.

Imagen: “This photograph shows the appearance of the German measles (rubella) rash.” por Parker N et al. Licencia: CC BY 4.0, recortada por Lecturio.

Diagnóstico, Tratamiento y Prevención

Diagnóstico

El diagnóstico se realiza clínicamente y se confirma con la detección del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum suero y estudios serológicos.

  • La infección congénita comúnmente involucra una tríada de cataratas, defectos cardiacos y sordera, que se detectan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el periodo neonatal.
  • La infección congénita se puede confirmar en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un recién nacido mediante la detección viral en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum sangre del cordón, secreciones nasofaríngeas u orina.
  • La infección congénita se confirma más comúnmente mediante RT-PCR RT-PCR A variation of the pcr technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard pcr protocols. Polymerase Chain Reaction (PCR) para detectar ARN de rubéola en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el líquido amniótico antes del nacimiento.
  • El virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology también se puede detectar a partir de las secreciones nasofaríngeas de pacientes embarazadas.
  • Para los LOS Neisseria casos posnatales, los LOS Neisseria anticuerpos IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions específicos contra la rubéola pueden detectarse mediante un inmunoensayo enzimático tan pronto como 4 días después del inicio del exantema.

Tratamiento y prevención

El tratamiento es de apoyo y dirigido según el sistema de órganos involucrado. La prevención se logra mediante la vacunación SPR o SPRV (sarampión, paperas, rubéola, varicela).

  • Primera dosis a los LOS Neisseria 12–15 meses de edad, segunda dosis a los LOS Neisseria 4–6 años de edad para cualquiera de las vacunas
  • La infección confiere inmunidad; sin embargo, se han documentado casos de reinfección.

Comparación de las Erupciones Infantiles Más Comunes

Tabla: Comparación de las erupciones comunes en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la infancia
Número Otros nombres de la enfermedad Etiología Descripción
1ra enfermedad
  • Sarampión
  • Sarampión de 14 días
  • Morbilli Morbilli Measles (also known as rubeola) is caused by a single-stranded, linear, negative-sense RNA virus of the family Paramyxoviridae. It is highly contagious and spreads by respiratory droplets or direct-contact transmission from an infected person. Typically a disease of childhood, measles classically starts with cough, coryza, and conjunctivitis, followed by a maculopapular rash. Measles Virus
Morbillivirus Morbillivirus A genus of the family paramyxoviridae (subfamily paramyxovirinae) where the virions of most members have hemagglutinin but not neuraminidase activity. All members produce both cytoplasmic and intranuclear inclusion bodies. Measles virus is the type species. Measles Virus del sarampión
  • Tos TOS Thoracic outlet syndrome (TOS) is a broad term used for a spectrum of syndromes related to the general region of the thoracic outlet, which involves the compression or irritation of elements of the brachial plexus, subclavian artery, or subclavian vein. Thoracic Outlet Syndrome, coriza, conjuntivitis
  • Manchas de Koplik (manchas blanco-azuladas con un halo rojo) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la membrana bucal
  • La erupción maculopapular Maculopapular Dermatologic Examination comienza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cara y detrás de las orejas → se extiende al AL Amyloidosis tronco/las extremidades.
2da enfermedad
  • Escarlatina
  • Fiebre escarlata
Streptococcus Streptococcus Streptococcus is one of the two medically important genera of gram-positive cocci, the other being Staphylococcus. Streptococci are identified as different species on blood agar on the basis of their hemolytic pattern and sensitivity to optochin and bacitracin. There are many pathogenic species of streptococci, including S. pyogenes, S. agalactiae, S. pneumoniae, and the viridans streptococci. Streptococcus pyogenes
  • Erupción maculopapular Maculopapular Dermatologic Examination con sensación de papel de lija que comienza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuello y la ingle → se extiende al AL Amyloidosis tronco/las extremidades
  • Zonas oscuras e hiperpigmentadas, especialmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria pliegues de la piel, llamadas líneas de Pastia.
  • Lengua de fresa: membrana blanca recubierta a través de la cual sobresalen papilas rojas e hinchadas
3ra enfermedad
  • Rubéola
  • Sarampión alemán
  • Sarampión de 3 días
Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la rubéola
  • Asintomática en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el 50% de los LOS Neisseria casos
  • Erupción macular fina en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cara (detrás de las orejas) → se extiende al AL Amyloidosis cuello, el tronco y las extremidades (no afecta las palmas de las manos ni las plantas de los LOS Neisseria pies).
  • Manchas de Forscheimer: Se pueden ver máculas rojas puntiformes y petequias sobre el paladar blando/úvula
  • Linfadenopatía dolorosa generalizada
4ta enfermedad
  • Síndrome de la piel escaldada por estafilococos
  • Enfermedad de Filatow-Dukes
  • Enfermedad de Ritter
Debido a las cepas de Staphylococcus aureus Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications. Brain Abscess que fabrican la toxina epidermolítica (exfoliativa)
  • Algunos creen que la cuarta enfermedad es un diagnóstico erróneo y, por tanto, inexistente.
  • El término se eliminó en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la década de 1960 y solo se usa para trivialidades médicas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la actualidad.
  • Comienza con una erupción eritematosa difusa que generalmente comienza alrededor de la boca → ampollas llenas de líquido o ampollas cutáneas → ruptura y descamación.
  • Signo de Nikolsky: La aplicación presión sobre la piel con un dedo (acariciar) resulta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum desprendimiento de las capas superiores.
5ta enfermedad Eritema infeccioso Eritrovirus o parvovirus B19 Parvovirus B19 Primate erythroparvovirus 1 (generally referred to as parvovirus B19, B19 virus, or sometimes erythrovirus B19) ranks among the smallest DNA viruses. Parvovirus B19 is of the family Parvoviridae and genus Erythrovirus. In immunocompetent humans, parvovirus B19 classically results in erythema infectiosum (5th disease) or “slapped cheek syndrome.” Parvovirus B19 (eritroparvovirus 1 de primates)
  • Eritema facial (erupción de “mejillas abofeteadas”) que consiste en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pápulas rojas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las mejillas
  • Comienza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cara → se extiende a las extremidades → se extiende al AL Amyloidosis tronco/glúteos.
  • Inicialmente confluente, luego se convierte en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum red o reticular al AL Amyloidosis aclararse
6ta enfermedad
  • Exantema súbito
  • Roséola infantum
  • Erupción de rosas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum bebés
  • Fiebre de 3 días
Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology del herpes humano 6B o 7
  • Aparición repentina de fiebre alta
  • Manchas de Nagayama: manchas papulares en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el paladar blando/úvula
  • La erupción comienza cuando la fiebre desaparece (el término «exantema súbito» describe la «sorpresa» de la erupción después de que la fiebre desaparece).
  • Numerosas máculas de color rosa, en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum forma de almendra, en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tronco y el cuello → a veces se extiende a la cara/las extremidades

Referencias

  1. Parkman PD. (1996). Togaviruses: Rubella Virus. In Baron S (Ed). Medical Microbiology. (4th ed). https://www-ncbi-nlm-nih-gov.online.uchc.edu/books/NBK8200/
  2. Frey TK. (1994). Molecular biology of rubella virus. Advances in virus research, 44, 69–160. https://doi-org.online.uchc.edu/10.1016/s0065-3527(08)60328-0
  3. CDC. Rubella. In: Epidemiology and Prevention of Vaccine-Preventable Diseases, 12th Ed, Atkinson W, Wolfe C, Hamborsky (Eds), Public Health Foundation, Washington, DC 2011.
  4. WHO fact sheet. Rubella. http://www.who.int/en/news-room/fact-sheets/detail/rubella
  5. Grant GB, Desai S, Dumolard L, Kretsinger K, & Reef SE. (2019). Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination – Worldwide, 2000-2018. MMWR. Morbidity and mortality weekly report, 68(39), 855–859. https://doi-org.online.uchc.edu/10.15585/mmwr.mm6839a5
  6. Miller S. (2015). Paramyxoviruses and Rubella Virus. In Brooks JE, et al. (Eds.), Jawetz, Melnick, & Adelberg’s Medical Microbiology. (27th ed). [VitalSource Bookshelf 9.4.3].
  7. Edwards MS. (2021). Rubella. UpToDate. Obtenido el 26 de abril de 2021 de https://www.uptodate.com/contents/rubella

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