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Factores de Crecimiento Hematopoyéticos

Los LOS Neisseria factores de crecimiento hematopoyéticos son una familia de glucoproteínas responsables de la proliferación y diferenciación de las células progenitoras hematopoyéticas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la médula ósea. La eritropoyetina, la trombopoyetina, el factor estimulante de colonias de granulocitos (G-CSF) y el factor estimulante de colonias de granulocitos y macrófagos ( GM-CSF GM-CSF An acidic glycoprotein of mw 23 kda with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. White Myeloid Cells: Histology) se utilizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum ciertos casos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria que la hematopoyesis normal está alterada debido a un tratamiento (e.g., quimioterapia) o una enfermedad subyacente (e.g., anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica). Comúnmente, los LOS Neisseria agentes estimulantes de la eritropoyesis se administran como parte del tratamiento de la anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types inducida por quimioterapia y la anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types secundaria a la ERC. G-CSF y GM-CSF GM-CSF An acidic glycoprotein of mw 23 kda with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. White Myeloid Cells: Histology se administran para tratar la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia inducida por quimioterapia. Los LOS Neisseria agentes estimulantes de la trombopoyesis se utilizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la prevención o el tratamiento de la trombocitopenia.

Last updated: Dec 15, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Descripción General

Definición

Los LOS Neisseria factores de crecimiento hematopoyéticos son glucoproteínas que regulan la proliferación, diferenciación y maduración de las células progenitoras, así como la función de las células maduras.

Hematopoyesis

  • La hematopoyesis es la formación de células sanguíneas:
    • Las células sanguíneas tienen una vida útil limitada, por lo que la capacidad de producir dichas células es una función importante del cuerpo para la renovación continua.
    • La hematopoyesis del adulto se produce en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la médula ósea.
    • La hematopoyesis fetal ocurre en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum diferentes órganos a medida que se desarrolla el feto:
      • Saco vitelino: 3–8 semanas
      • Hígado: 6 semanas–nacimiento
      • Bazo: 10–28 semanas
      • Médula ósea: después de 18 semanas
  • Las células madre hematopoyéticas se desarrollan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un microambiente complejo que consta de matriz extracelular y células del estroma:
    • Pasan por una serie de pasos → dan lugar a progenitores linfoides comunes y progenitores mieloides comunes (que son colonias de linaje de células sanguíneas mixtas)
    • Los LOS Neisseria progenitores mieloides comunes dan lugar a progenitores específicos → unidades formadoras de colonias, que experimentan proliferación y diferenciación
  • Las unidades formadoras de colonias impactan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el desarrollo de más alto grado de maduración.

Principales factores de crecimiento hematopoyéticos y agentes farmacológicos

Tabla: Principales factores de crecimiento hematopoyéticos y agentes farmacológicos
Citocinas/factores de crecimiento Función Agente(s) farmacológico(s)
Eritropoyetina Estimula la eritropoyesis, incluida la diferenciación
  • Epoetina alfa
  • Darbepoetina alfa
  • Metoxipolietilenglicol-epoetina beta
Factor estimulante de colonias de granulocitos y macrófagos ( GM-CSF GM-CSF An acidic glycoprotein of mw 23 kda with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. White Myeloid Cells: Histology) Estimula las células progenitoras mieloides Sargramostim Sargramostim Hematopoietic Growth Factors
Factor estimulante de colonias de granulocitos (G-CSF) Estimula las células precursoras de neutrófilos
Trombopoyetina (TPO) Estimula la trombopoyesis
IL-11 Estimula la trombopoyesis Oprelvekin Oprelvekin Hematopoietic Growth Factors
Hematopoyesis de la médula ósea

Hematopoyesis de la médula ósea: proliferación y diferenciación de los elementos formes de la sangre.
IL-3: interleucina-3
CFU-GEMM: unidad formadora de colonias: granulocitos, eritrocitos, monocitos, megacariocitos
IL-2: interleucina-2
IL-6: interleucina-6
CFU-GM: unidad formadora de colonias-granulocitos-macrófagos
GM-CSF: factor estimulante de colonias de granulocitos y macrófagos
M-CSF: factor estimulante de colonias de macrófagos
G-CSF: factor estimulante de colonias de granulocitos
IL-5: interleucina-5
NK: célula asesina natural
TPO: trombopoyetina
EPO: eritropoyetina

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Agentes Estimulantes de la Eritropoyesis

Definición

Los LOS Neisseria agentes estimulantes de la eritropoyesis son sustancias farmacológicas que estimulan la producción de eritrocitos y se utilizan para tratar la anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types debida a una variedad de afecciones.

Agentes

  • Epoetina alfa: eritropoyetina humana recombinante
  • Darbepoetina alfa: análogo de la eritropoyetina con cadenas de oligosacáridos adicionales
  • Metoxipolietilenglicol-epoetina beta: activador del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de eritropoyetina de acción prolongada
Tabla: Mecanismo de acción, farmacocinética e indicaciones de los LOS Neisseria agentes estimulantes de la eritropoyesis
Medicamento Mecanismo de acción Farmacocinética Indicaciones
Epoetina alfa
  • Estimula la proliferación y diferenciación de células progenitoras
  • Provoca la liberación de reticulocitos
  • Aumenta la hemoglobina y el hematocrito
  • Intravenosa, subcutánea
  • Absorción subcutánea lenta
  • ↑ Reticulocitos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 10 días
  • Efecto máximo: ↑ hemoglobina en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 2 a 6 semanas
  • Distribución similar al AL Amyloidosis plasma Plasma The residual portion of blood that is left after removal of blood cells by centrifugation without prior blood coagulation. Transfusion Products extracelular
  • Vida media de eliminación:
    • ≤ 67 horas (Subcutánea)
    • 4-13 horas (Intravenosa): ERC
  • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de 2do grado por:
    • Enfermedad renal crónica
    • Quimioterapia
    • Medicamento (zidovudina)
  • ↓ Transfusión alogénica para cirugía electiva, no cardíaca, no vascular
Darbepoetina alfa
  • Intravenosa, subcutánea
  • Absorción subcutánea lenta
  • Efecto máximo: ↑ hemoglobina en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 2 a 6 semanas
  • Intravenosa: vida media más larga que la epoetina alfa
  • Vida media de eliminación:
    • 21 horas (intravenosa)
    • 70 horas (Subcutánea); más corta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum diálisis
Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de 2do grado por:
  • Enfermedad renal crónica
  • Quimioterapia
Metoxipolietilenglicol-epoetina beta
  • Intravenosa, Subcutánea
  • Efecto máximo: ↑ hemoglobina en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 7–15 días
  • Vida media de eliminación:
    • 119 horas (intravenosa)
    • 124 horas (Subcutánea)
Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de 2do grado por ERC

Efectos secundarios

  • Cardiovasculares:
    • Hipertensión
    • ↑ Riesgo de IM
    • Accidente cerebrovascular
    • Tromboembolismo venoso
    • Trombosis de acceso vascular
  • Náuseas y vómitos
  • Artralgia
  • Erupción, prurito y, en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum casos graves: necrólisis epidérmica tóxica, síndrome de Stevens-Johnson
  • Progresión tumoral en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum ciertos tipos de cáncer
  • Convulsiones

Contraindicaciones

  • Reacciones hipersensibles
  • Hipertensión mal controlada
  • Aplasia Aplasia Cranial Nerve Palsies eritrocitaria pura tras tratamiento con agentes estimulantes de la eritropoyesis
  • Las formulaciones que contienen peróxido de benzoílo están contraindicadas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum recién nacidos y durante los LOS Neisseria períodos periparto y lactancia.

Factores de Crecimiento Mieloides

Definición

Los LOS Neisseria factores de crecimiento mieloides son agentes que estimulan la proliferación y diferenciación de ≥ 1 tipo de células mieloides y se utilizan para tratar los LOS Neisseria recuentos bajos de neutrófilos.

Agentes

  • G-CSF recombinante:
    • Filgrastim Filgrastim A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of neutropenia, preparation and collection of blood progenitor cells, and for use in peripheral blood stem cell transplantation. Hematopoietic Growth Factors ( Neupogen Neupogen A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of neutropenia, preparation and collection of blood progenitor cells, and for use in peripheral blood stem cell transplantation. Hematopoietic Growth Factors)
    • Pegfilgrastim Pegfilgrastim Hematopoietic Growth Factors (Neulasta) es una forma pegilada de G-CSF: la formulación permite una vida media más larga.
  • GM-CSF GM-CSF An acidic glycoprotein of mw 23 kda with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. White Myeloid Cells: Histology recombinante: sargramostim Sargramostim Hematopoietic Growth Factors
Tabla: Mecanismo de acción, farmacocinética e indicaciones de los LOS Neisseria factores de crecimiento mieloides
Medicamento Mecanismo de acción Farmacocinética Indicaciones
Filgrastim Filgrastim A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of neutropenia, preparation and collection of blood progenitor cells, and for use in peripheral blood stem cell transplantation. Hematopoietic Growth Factors
  • Estimula las UFC-G
  • ↑ Producción de neutrófilos
  • Intravenosa, subcutánea
  • Efecto máximo: 2 a 8 horas (SC)
  • Vida media de eliminación: aproximadamente 3,5 horas
  • Degradado sistemáticamente
  • LMA (después de la inducción)
  • Mielosupresión por quimioterapia
  • Trasplante de médula ósea (TMO) (↓ neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia)
  • Células progenitoras de sangre periférica para recolección de aféresis
  • Síndrome de lesión hematopoyético por radiación
  • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia crónica severa
Pegfilgrastim Pegfilgrastim Hematopoietic Growth Factors
  • Intravenosa, subcutánea
  • Efecto máximo: 24 horas
  • Vida media de eliminación: 15–80 horas
  • Se excreta mediante la unión a neutrófilos
  • Síndrome de lesión hematopoyético por radiación
  • Previene la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la quimioterapia
Sargramostim Sargramostim Hematopoietic Growth Factors
  • Factor estimulante de colonias
  • ↑ Mielopoyesis (proliferación, diferenciación y actividad de neutrófilos, eosinófilos, macrófagos, monocitos)
  • Intravenosa, subcutánea
  • Efecto máximo: hasta 4 horas (subcutánea)
  • ↑ Leucocitos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 1–2 semanas
  • ↓ Leucocitos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 2 a 10 días después de la interrupción
  • Vida media de eliminación: 3,8 horas (intravenosa), 1,4 horas (subcutánea)
  • LMA (después de la inducción)
  • TMO alogénico o autólogo
  • Moviliza células progenitoras autólogas de sangre periférica para su recolección (mediante leucaféresis)
  • Acelera la reconstitución mieloide después del TMO
  • Síndrome de lesión hematopoyético por radiación
TMO: trasplante de médula ósea
UFC-G: unidad formadora de colonias-granulocitos

Efectos secundarios

  • Filgrastim Filgrastim A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of neutropenia, preparation and collection of blood progenitor cells, and for use in peripheral blood stem cell transplantation. Hematopoietic Growth Factors y pegfilgrastim Pegfilgrastim Hematopoietic Growth Factors:
    • Dolor Dolor Inflammation óseo
    • Diarrea, náuseas, vómitos
    • Ruptura esplénica
    • Síndrome de dificultad respiratoria aguda, hemorragia alveolar
    • Aortitis Aortitis Inflammation of the wall of the aorta. Ankylosing Spondylitis, dolor Dolor Inflammation torácico
    • Nefrotoxicidad
    • Vasculitis Vasculitis Inflammation of any one of the blood vessels, including the arteries; veins; and rest of the vasculature system in the body. Systemic Lupus Erythematosus cutánea
    • Síndrome de fuga capilar
    • Síndrome de Sweet: neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia febril aguda con hallazgos dermatológicos
    • Crisis de células falciformes
    • Leucocitosis (leucocitos ≥ 100 000/mm³)
    • Síndrome mielodisplásico, LMA
  • Sargramostim Sargramostim Hematopoietic Growth Factors:
    • Arritmias cardíacas, hipertensión, edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema, dolor Dolor Inflammation torácico
    • Náuseas, vómitos, diarrea, dolor Dolor Inflammation abdominal, ↑ bilirrubina
    • ↑ Creatinina
    • Síndrome de fuga capilar
    • Hemorragia intraocular
    • Leucocitosis
    • Reacción de infusión
    • Crecimiento tumoral (especialmente neoplasias malignas mieloides)

Contraindicaciones

  • Reacción alérgica/de hipersensibilidad grave
  • Para sargramostim Sargramostim Hematopoietic Growth Factors: contraindicado con > 10% de blastos mieloides leucémicos ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum MO o sangre periférica)

Factores de Crecimiento Trombopoyéticos

Definición

Los LOS Neisseria factores de crecimiento trombopoyéticos estimulan la trombopoyesis mediante la acción de la IL-11 o mediante la activación del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de TPO.

Agentes

Tabla: Mecanismo de acción, farmacocinética e indicaciones de los LOS Neisseria factores de crecimiento trombopoyéticos
Medicamento Mecanismo de acción Farmacocinética Indicaciones
Oprelvekin Oprelvekin Hematopoietic Growth Factors Estimula la megacariocitopoyesis y la trombopoyesis
  • Intravenosa, subcutánea
  • Vida media: aproximadamente 7 horas
  • ↑ Plaquetas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 5–9 días
Previene la trombocitopenia grave en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes que reciben quimioterapia para el cáncer no mieloide
Romiplostim Romiplostim Hematopoietic Growth Factors ↑ Plaquetas al AL Amyloidosis unirse al AL Amyloidosis receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de TPO
  • subcutánea
  • Vida media: 3,5 días (promedio); hasta 34 días
  • Aumento máximo de plaquetas: 12 a 16 días
  • Trombocitopenia inmune
  • Síndrome hematopoyético del síndrome de radiación aguda
Eltrombopag Eltrombopag Hematopoietic Growth Factors
  • Oral
  • Vida media: aproximadamente 32 horas
  • Aumento máximo de plaquetas: 1 a 2 semanas
  • Excreción fecal
  • Trombocitopenia inmune
  • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica severa
  • Trombocitopenia asociada a hepatitis C Hepatitis C Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). The infection can be transmitted through infectious blood or body fluids and may be transmitted during childbirth or through IV drug use or sexual intercourse. Hepatitis C virus can cause both acute and chronic hepatitis, ranging from a mild to a serious, lifelong illness including liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis C Virus crónica

Efectos secundarios

  • Oprelvekin Oprelvekin Hematopoietic Growth Factors:
    • Náuseas, vómitos, diarrea
    • Disnea, tos TOS Thoracic outlet syndrome (TOS) is a broad term used for a spectrum of syndromes related to the general region of the thoracic outlet, which involves the compression or irritation of elements of the brachial plexus, subclavian artery, or subclavian vein. Thoracic Outlet Syndrome, derrames pleurales
    • Arritmias auriculares
    • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
    • Inyección conjuntival
    • Visión borrosa
    • Reacción en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el sitio de la inyección
  • Romiplostim Romiplostim Hematopoietic Growth Factors:
  • Eltrombopag Eltrombopag Hematopoietic Growth Factors:
    • Tromboembolismo
    • Infección de las vías respiratorias superiores
    • Tos TOS Thoracic outlet syndrome (TOS) is a broad term used for a spectrum of syndromes related to the general region of the thoracic outlet, which involves the compression or irritation of elements of the brachial plexus, subclavian artery, or subclavian vein. Thoracic Outlet Syndrome, faringitis
    • Diarrea, vómitos
    • Mialgia
    • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
    • Catarata
    • Hepatotoxicidad
    • Progresión del síndrome mielodisplásico → LMA

Contraindicaciones

Para todos los LOS Neisseria agentes, la hipersensibilidad al AL Amyloidosis medicamento o a los LOS Neisseria componentes es una contraindicación.

Referencias

  1. Medscape Drug Information. (2020). Darbepoetin alfa (Rx). Retrieved June 25, 2021, from https://reference.medscape.com/drug/aranesp-darbepoetin-alfa-342150#5
  2. DeVita, V. T., Jr., Lawrence, T. S., Rosenberg, S. A. (2019). Devita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 11th ed. Philadelphia: Wolters Kluwer, pp. 1746–1748.
  3. Elliott, S., Pham, E., Macdougall, I.C. (2008). Erythropoietins: a common mechanism of action. Exp Hematol 36:1573–1584. https://pubmed.ncbi.nlm.nih.gov/18922615/
  4. Medscape Drug Information. (2020). Epoetin alfa (Rx). Retrieved June 25, 2021, from https://reference.medscape.com/drug/epogen-procrit-epoetin-alfa-342151#5
  5. Medscape Drug Information. (2020). Filgrastim (Rx). Retrieved June 26, 2021, from https://reference.medscape.com/drug/g-csf-neupogen-filgrastim-342164#4
  6. Ghanima, W., Cooper, N., Rodeghiero, F., Godeau, B., Bussel, J. B. (2019). Thrombopoietin receptor agonists: ten years later. Haematologica 104:1112–1123. https://doi.org/10.3324/haematol.2018.212845
  7. Hubulashvili, D., Marzella, N. (2009). Romiplostim (Nplate), a treatment option for immune (idiopathic) thrombocytopenic purpura. Pharmacy and Therapeutics 34:482–485. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799136/
  8. Kuter, D. (2021). Clinical applications of thrombopoietin growth factors. UpToDate. Retrieved September 13, 2021, from https://www.uptodate.com/contents/clinical-applications-of-thrombopoietic-growth-factors
  9. Medscape Drug Information. (2019). Methoxy polyethylene glycol/epoetin beta (Rx). Retrieved June 25, 2021, from https://reference.medscape.com/drug/mircera-methoxy-polyethylene-glycol-epoetin-beta-342153#5
  10. Medscape Drug Information. (2019). Oprelvekin (Rx). Retrieved June 26, 2021, from https://reference.medscape.com/drug/neumega-interleukin-11-oprelvekin-342165#4
  11. Medscape Drug Information. (2021). Pegfilgrastim (Rx). Retrieved June 26, 2021, from https://reference.medscape.com/drug/neulasta-fulphila-pegfilgrastim-342167#4
  12. Medscape Drug Information. (2021). Romiplostim (Rx). Retrieved September 14, 2021, from https://reference.medscape.com/drug/nplate-romiplostim-342177#5
  13. Medscape Drug Information. (2019). Sargramostim (Rx). Retrieved September 14, 2021, from https://reference.medscape.com/drug/leukine-sargramostim-342166#4
  14. Schoener, B., Borger, J. (2021). Erythropoietin. StatPearls. Retrieved June 25, 2021, from https://www.ncbi.nlm.nih.gov/books/NBK536997/
  15. Zehnder, J. L. (2017). Agents used in cytopenias; hematopoietic growth factors. In: Katzung, B. G., et al. (Eds.), Basic & Clinical Pharmacology. New York: McGraw-Hill Medical, pp. 600–606. 

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