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Virus de la Hepatitis D

El virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus ( HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) es un virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology pequeño de ARN monocatenario, envuelto. El virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus se considera un virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology satélite, ya que requiere la presencia del virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus ( HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) para su ensamblaje y secreción. Por lo tanto, para que un individuo contraiga la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus, se requiere la coinfección o sobreinfección con el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus. Al AL Amyloidosis igual que el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus, el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus se transmite por vía parenteral, a través de relaciones sexuales sin protección, o por vía perinatal. La presentación clínica es la de una hepatitis vírica clásica, incluida la coinfección por el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus y el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus, que se considera la forma más grave de hepatitis debido a la elevada tasa de mortalidad. En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria casos agudos, el tratamiento es de apoyo, mientras que en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria casos crónicos se necesita interferón alfa pegilado.

Last updated: Jan 17, 2024

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Clasificación

Diagrama de flujo de la clasificación de los virus de ARN

Identificación de los virus ARN:
Los virus pueden clasificarse de muchas maneras. Sin embargo, la mayoría de los virus tienen un genoma formado por ADN o ARN. Los virus con genoma ARN pueden caracterizarse además por tener ARN monocatenario o bicatenario. Los virus “envueltos” están cubiertos por una fina capa de membrana celular (normalmente tomada de la célula huésped). Si la capa está ausente, los virus se denominan “desnudos”. Los virus con genomas monocatenarios son positivos si el genoma se emplea directamente como ARN mensajero (ARNm), que se traduce en proteínas. Los virus monocatenarios negativos emplean la ARN polimerasa, una enzima viral, para transcribir su genoma en ARNm.

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

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Características Generales

Estructura

  • Familia: Kolmioviridae Kolmioviridae Hepatitis D Virus, género: Deltavirus
  • ARN circular monocatenario
  • Genoma de sentido negativo
  • Pequeño (aproximadamente 36 nm de diámetro)
  • Partícula viral incompleta o defectuosa → se asemeja a un viroide.
  • La envoltura contiene el antígeno de superficie de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus ( HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus).
  • Se conocen 8 especies de virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus ( HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus).

Características

  • Causa hepatitis aguda o crónica.
  • Diferencia con el virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology satélite clásico: El HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus no tiene similitud de secuencia con el virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus → puede replicarse independientemente del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus, pero requiere del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus para el ensamblaje y la secreción completa del virión.
  • Depende de la maquinaria de la célula huésped para su replicación.
  • Disminuye la replicación del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la mayoría de los LOS Neisseria individuos (mecanismo no entendido en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum su totalidad).
Hepatitis D virus

Virus de la hepatitis D (HDV):
El virión de la hepatitis D está formado por un ARN circular monocatenario (ARN del HDV), un único antígeno codificado por el HDV (HDAg) y una envoltura lipoproteica (HbsAg), que proviene del virus de la hepatitis B (HBV).

Imagen por Lecturio.

Epidemiología

  • Prevalencia:
    • Alrededor del 5% de los LOS Neisseria individuos con hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus a nivel mundial tienen coinfección por el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus(15–20 millones de personas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum total).
    • Adultos >> niños
    • Mayor prevalencia: Mongolia, República de Moldavia, África Occidental y Central
    • La prevalencia disminuye debido al AL Amyloidosis aumento de las tasas de vacunación contra el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus.
  • La coinfección/sobreinfección HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus es la forma más grave de hepatitis viral crónica → rápida progresión hacia el carcinoma hepatocelular y la muerte relacionada con el hígado.

Patogénesis

Transmisión

La transmisión de la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus es similar a la de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus.

  • Relaciones sexuales sin protección
  • Por vía parenteral (agujas compartidas de drogas intravenosas, pinchazos accidentales con agujas)
  • De madre a hijo (más común en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum zonas de alta prevalencia)

Factores de riesgo del huésped

  • Personas que se inyectan drogas
  • Personas que tienen relaciones sexuales sin protección con múltiples parejas
  • Hombres que tienen sexo con hombres
  • Infección por VIH
  • Hemodiálisis
  • Bebés nacidos de madres seropositivas al AL Amyloidosis HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus
  • Profesiones con exposición a sangre humana, fluidos seminales y/o fluidos vaginales
  • Personas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum hemodiálisis o receptores de órganos o transfusiones de sangre

Fisiopatología

  • La infección por el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus solo puede producirse como coinfección o sobreinfección con el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus.
  • El HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus infecta las células hepáticas → expresa péptidos virales en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum su superficie a través de un transportador biliar.
  • El HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus reconoce su receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors por medio del antígeno de superficie de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus.
  • Después de entrar en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hepatocito, el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus no está recubierto → utiliza las ARN polimerasas celulares del huésped para replicarse.
  • Los LOS Neisseria péptidos activan los LOS Neisseria linfocitos (linfocitos T citotóxicas CD8+) → los LOS Neisseria leucocitos montan una respuesta inmunitaria celular contra las células hepáticas infectadas → destrucción de los LOS Neisseria hepatocitos → inflamación del hígado.

Presentación Clínica

General

  • La infección por el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus es clínicamente indistinguible de otras formas de hepatitis vírica.
  • El 90% de los LOS Neisseria casos son asintomáticos.
  • Período de incubación:
    • Coinfección: 1–6 meses
    • Sobreinfección: 2–8 semanas
  • Posibles síntomas:
    • Náuseas, vómitos
    • Ictericia
    • Fiebre
    • Cansancio
    • Orina oscura
    • Dolor Dolor Inflammation abdominal
    • Mialgias, artralgias

Coinfección

  • Solo si el individuo es anti-Hbs anti-HBs Hepatitis B Virus negativo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el momento de la infección
  • Clínicamente no se distingue de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus clásica.
  • Los LOS Neisseria individuos pueden ser asintomáticos durante la infección inicial.
  • Mayor incidencia de insuficiencia hepática en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las personas que usan drogas inyectables

Sobreinfección

  • Puede presentarse como una hepatitis aguda grave (estado de portador del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus no reconocido) o una exacerbación de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus crónica.
  • Acelera la progresión hacia una enfermedad más grave (cirrosis, carcinoma hepatocelular) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum todas las edades.
  • La replicación del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus se reduce con la infección por el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus (mecanismo no entendido en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum su totalidad).

Diagnóstico y Tratamiento

Diagnóstico

  • Marcadores virales (suero)
    • HbsAg: tiene que ser positivo para el diagnóstico del VHD
    • Marcadores tempranos: IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions anti-VHD y ARN del VHD
    • Anticuerpos IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions contra el antígeno del núcleo de la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus ( IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions anti-HBc anti-HBc Hepatitis B Virus): coinfección aguda VHB/VHD
    • Antígeno delta (HDAg) sérico (antígeno de la hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus):
      • Detectado por inmunoensayo enzimático ( EIA EIA HIV Infection and AIDS) o radioinmunoensayo (RIA)
      • Positivo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las primeras 2 semanas de la infección aguda
      • Frecuentemente no se detecta
    • Marcador tardío: IgG IgG The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of igg, for example, igg1, igg2a, and igg2b. Hypersensitivity Pneumonitis anti-VHD
  • Antígeno delta (HDAg) hepático:
    • Detectado por inmunohistoquímica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum tejido hepático (biopsia)
    • No se suele utilizar como prueba inicial
  • Pruebas de laboratorio adicionales:
    • Niveles de ALT ALT An enzyme that catalyzes the conversion of l-alanine and 2-oxoglutarate to pyruvate and l-glutamate. Liver Function Tests y AST AST Enzymes of the transferase class that catalyze the conversion of l-aspartate and 2-ketoglutarate to oxaloacetate and l-glutamate. Liver Function Tests
    • Signos de enfermedad grave:
      • Hipoalbuminemia
      • Bilirrubinas elevadas
      • Hemólisis
      • Trombocitopenia
      • INR elevado
Tabla: Infección por Hepatitis D Hepatitis D Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis d can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis b, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis D Virus
Marcadores séricos Coinfección por HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus/ HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus aguda Superinfección aguda por HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus Infección crónica por HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus
HBsAg Positivo Positivo Positivo
Anti-HBc anti-HBc Hepatitis B Virus IgM IgM A class of immunoglobulin bearing mu chains (immunoglobulin mu-chains). Igm can fix complement. The name comes from its high molecular weight and originally being called a macroglobulin. Immunoglobulins: Types and Functions Positivo Negativo Negativo
RNA RNA A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. RNA Types and Structure HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus sérico Temprano, transitorio Temprano, persistente Positivo
HDAg sérico* Positivo (transitorio) Positivo (transitorio) Negativo
Anti-HDV IgM Anti-HDV IgM Hepatitis D Virus Positivo (transitorio) Positivo (persistente y títulos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum incremento) Positivo (títulos altos)
Anti-HDV IgG Anti-HDV IgG Hepatitis D Virus Positivo (tardío) Positivo (tardío) Positivo (títulos altos)
Anti-HBc: Antígeno core de la hepatitis
HBsAg: Antígeno de superficie de la hepatitis B
HDAg: Antígeno del virus de la hepatitis D
HDV: Virus de la hepatitis D
IgG: Inmunoglobulina G
IgM: Inmunofgobulina M
*La detección de HDAg es limitada; por tanto, el HDAg se pasa por alto con frecuencia.

Tratamiento

  • Enfermedad aguda: soporte, no hay terapia específica disponible.
  • Enfermedad crónica: interferón alfa convencional o pegilado
    • Administrado durante al AL Amyloidosis menos 48 semanas
    • Eficiencia de aproximadamente el 20%
    • Solo es eficaz mientras se administra.
    • Contraindicaciones: cirrosis descompensada, enfermedades psiquiátricas activas, enfermedades autoinmunes

Prevención

  • La prevención del HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus se basa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum detener la propagación del HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus.
  • La vacunación contra el HBV HBV Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Hepatitis B virus is transmitted by exposure to infectious blood or body fluids. Examples of types of exposure include sexual intercourse, IV drug use, and childbirth. Hepatitis B Virus es la forma más eficaz de prevenir el HDV HDV Hepatitis D virus (HDV) is a small enveloped, single-stranded RNA virus. Hepatitis D virus is considered a satellite virus, as it requires the presence of hepatitis B virus (HBV) for assembly and secretion. Therefore, in order for an individual to contract hepatitis D, coinfection or superinfection with HBV is required. Hepatitis D Virus:
    • Para todos los LOS Neisseria bebés y niños hasta los LOS Neisseria 18 años (recomendado por la OMS y los LOS Neisseria CDC)
    • Para los LOS Neisseria adultos, especialmente los LOS Neisseria que pertenecen a grupos de alto riesgo
    • Se requieren 3 dosis para completar la serie de vacunas contra la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus.
    • Series de 2 dosis disponibles para adolescentes y adultos
    • Bebés nacidos de madres infectadas: Deben recibir la primera dosis en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las 1as 12 horas de vida.
  • Otras medidas:
    • Medidas de seguridad para la manipulación de productos sanguíneos
    • Prácticas de inyección seguras
    • Profilaxis posterior a la exposición: inmunoglobulina contra la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus o vacuna contra la hepatitis B Hepatitis B Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which belongs to the Orthohepadnavirus genus and the Hepadnaviridae family. Most individuals with acute HBV infection are asymptomatic or have mild, self-limiting symptoms. Chronic infection can be asymptomatic or create hepatic inflammation, leading to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B Virus

Comparación de los Virus de la Hepatitis

Hepatitis A–E in comparison

Anti-HBc antibodies: anticuerpos del núcleo de la hepatitis B
Anti-HBs antibodies: anticuerpos de superficie contra la hepatitis B
HBcAg: antígeno del núcleo de la hepatitis B
HBsAg: antígeno de superficie de la hepatitis B
HBV: virus de la hepatitis B
HCC: carcinoma hepatocelular
HCV: virus de la hepatitis C
HDV: virus de la hepatitis D

Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Diagnóstico Diferencial

  • Enfermedad hepática alcohólica: Patología hepática que se produce por el consumo excesivo y prolongado de alcohol. La primera etapa es un hígado graso asintomático, que es reversible. La segunda etapa es la hepatitis alcohólica, que suele presentarse con ictericia, fiebre y dolor Dolor Inflammation en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región abdominal. La tercera etapa es la cirrosis hepática. El diagnóstico se establece mediante los LOS Neisseria antecedentes clínicos, las pruebas de función hepática y los LOS Neisseria estudios de imagenología.
  • Lesión hepática inducida por medicamentos: Se produce cuando los LOS Neisseria medicamentos ingeridos causan lesiones en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria hepatocitos directamente de forma predecible y dependiente de la dosis o a través de reacciones idiosincrásicas. La presentación de la lesión hepática inducida por medicamentos puede ser aguda o crónica, con una toxicidad grave que se manifiesta como una insuficiencia hepática fulminante. El diagnóstico de la lesión hepática inducida por medicamentos requiere una anamnesis completa y pruebas de laboratorio. El tratamiento consiste en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el diagnóstico precoz y la interrupción del medicamento, así como la terapia de soporte.
  • Hepatitis autoinmune: Inflamación del hígado que se produce cuando el sistema inmunitario del organismo ataca a sus propias células hepáticas. La presentación clínica va VA Ventilation: Mechanics of Breathing desde lo asintomático hasta los LOS Neisseria síntomas de insuficiencia hepática aguda. El diagnóstico se establece mediante un análisis de sangre para detectar los LOS Neisseria autoanticuerpos característicos (especialmente, los LOS Neisseria anticuerpos contra el músculo liso) y una biopsia de hígado. El tratamiento incluye corticosteroides y azatioprina.
  • Enfermedad de Wilson: Trastorno autosómico recesivo por una mutación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el gen ATP7B, que regula el transporte de cobre en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria hepatocitos. Las manifestaciones neuropsiquiátricas de la enfermedad de Wilson ayudan a diferenciarla de otras causas de hepatitis. En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las primeras fases, la enfermedad de Wilson puede confundirse con la encefalopatía hepática. Anillos de Kayser-Fleischer, los LOS Neisseria niveles bajos de ceruloplasmina ayudan a separar la enfermedad de Wilson de otras causas de hepatitis.
  • Enfermedad del hígado graso no alcohólico: Espectro de patología hepática que surge debido a la acumulación de triglicéridos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria hepatocitos. La enfermedad del hígado graso no alcohólico va VA Ventilation: Mechanics of Breathing desde el hígado graso o la esteatosis hepática hasta la esteatohepatitis no alcohólica, que presenta depósitos grasos e inflamación. La lesión hepática progresiva y la fibrosis Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. Bronchiolitis Obliterans se convierten irreversiblemente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cirrosis y, posiblemente, en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cáncer primario de hígado. El tratamiento se realiza con modificaciones del estilo de vida (dieta y ejercicio).

Referencias

  1. Roy P. (2021). Hepatitis D. Emedicine. Retrieved January 28, 2021, from https://emedicine.medscape.com/article/178038-overview#a6
  2. Rizzetto M, Verme G. (1985). Delta hepatitis—present status. J Hepatol 1:187–193.
  3. Samuel D, Zignego AL, Reynes M, et al. (1995). Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis. Hepatology 21:333–339.
  4. Abbas Z, Afzal R. (2013). Life cycle and pathogenesis of hepatitis D virus: a review. World J Hepatol 5:666–675.
  5. Negro, F., & Lok, A. S. F. (2024). Epidemiology, clinical manifestations, and diagnosis of hepatitis D virus infection. In E. Tapper & K. M. Robson (Eds.), UpToDate. Wolters Kluwer. Retrieved June 4, 2025, from https://www.uptodate.com/contents/epidemiology-clinical-manifestations-and-diagnosis-of-hepatitis-d-virus-infection
  6. Bichko V, Netter HJ, Wu TT, Taylor J. (1994). Pathogenesis associated with replication of hepatitis delta virus. Infectious Agents and Disease 3(2-3):94–97.
  7. Stockdale AJ, Kreuels B, Henrion M, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM. (2020). The global prevalence of hepatitis D virus infection: systematic review and meta-analysis. Journal of Hepatology 73:523–532. https://doi.org/10.1016/j.jhep.2020.04.008
  8. World Health Organization (WHO). Hepatitis D factsheet. Retrieved August 7, 2021, from https://www.who.int/news-room/fact-sheets/detail/hepatitis-d
  9. Masood, U., John, S. (2021) Hepatitis D. StatPearls. Retrieved June 27, 2022, from https://www.ncbi.nlm.nih.gov/books/NBK470436
  10. Negro, F., Lok, A. (2020) Treatment and prevention of hepatitis D virus infection. UpToDate. Retrieved June 27, 2022, from https://www.uptodate.com/contents/treatment-and-prevention-of-hepatitis-d-virus-infection

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