Diuréticos Ahorradores de Potasio

Los LOS Neisseria diuréticos ahorradores de potasio son medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células principales de los LOS Neisseria conductos colectores para inducir una diuresis, pero evitando la excreción de potasio. Estos diuréticos incluyen 2 subclases: los LOS Neisseria bloqueadores de los LOS Neisseria canales de sodio y los LOS Neisseria antagonistas de la aldosterona. Debido a que estos agentes actúan tan distalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la nefrona, no hay una pérdida significativa de potasio asociada a su uso. Estos agentes se utilizan normalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tratamiento del exceso de mineralocorticoides, que puede ser primario (e.g., el síndrome de Conn) o secundario (e.g., estados de disminución del volumen intravascular, especialmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con insuficiencia cardíaca). Además, la espironolactona puede utilizarse por sus propiedades antiandrogénicas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres con exceso de andrógenos (e.g., hirsutismo) y para la supresión de andrógenos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres transgénero (de hombre a mujer). Estos medicamentos están contraindicados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum caso de hiperpotasemia.

Last updated: Dec 15, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Contents

Descripción General

Estructura Química y Farmacodinamia

Farmacocinética

Indicaciones

Efectos Secundarios y Contraindicaciones

Comparación de Medicamentos

Referencias

Descripción General

Definición

Diuréticos ahorradores de potasio — Los diuréticos ahorradores de potasio actúan en los conductos colectores de la nefrona.
Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Descripción general de los LOS Neisseria agentes antihipertensivos

**Tabla: Medicamentos utilizados para tratar la hipertensión**
Sitio de acción	Clase	Subclases
Medicamentos renales	Medicamentos que afectan al AL Amyloidosis SRAA	IECA ARA Inhibidores directos de la renina
Medicamentos renales	Diuréticos	Diuréticos tiazídicos Diuréticos de asa ASA Anterior Cord Syndrome Diuréticos ahorradores de potasio
Medicamentos extrarrenales	Vasodilatadores directos	Bloqueadores de los LOS Neisseria canales de calcio Activadores de los LOS Neisseria canales de potasio Nitrodilatadores Antagonistas de la endotelina
Medicamentos extrarrenales	Agentes que actúan a través del sistema nervioso simpático	Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la vía eferente simpática del SNC (e.g., clonidina) Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria ganglios (e.g., hexametonio) Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las terminales nerviosas (e.g., guanetidina, reserpina) Medicamentos que actúan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria receptores α y β

Medicamentos de la clase de los LOS Neisseria diuréticos ahorradores de potasio

Los LOS Neisseria medicamentos de esta clase incluyen:

Antagonistas de la aldosterona:
- Espironolactona
- Eplerenona
Bloqueadores de los LOS Neisseria canales de sodio:
- Triamtereno
- Amilorida

Estructura Química y Farmacodinamia

Estructura química

Espironolactona y eplerenona: esteroides sintéticos
Triamtereno: derivado de la pteridina
Amilorida: derivado de la pirazina

Estructura del triamtereno
Imagen: “Estructura del triamtereno” por NEUROtiker. Licencia: Dominio Público

Mecanismo de acción y efectos fisiológicos

Antagonistas de la aldosterona (espironolactona, eplerenona):

También llamados antagonistas de los LOS Neisseria receptores de mineralocorticoides
Mecanismo de acción: Se unen al AL Amyloidosis receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors mineralocorticoide basolateral en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el conducto colector como antagonista competitivo del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de aldosterona, bloqueando los LOS Neisseria efectos de la aldosterona.
Efectos de la aldosterona:
- La aldosterona estimula la producción de las siguientes proteínas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células principales del conducto colector:
  - Na⁺/K⁺-ATPasa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región basolateral
  - ENaC ENaC Sodium channels found on salt-reabsorbing epithelial cells that line the distal nephron; the distal colon; salivary ducts; sweat glands; and the lung. They are amiloride-sensitive and play a critical role in the control of sodium balance, blood volume, and blood pressure. Liddle Syndrome (canal de sodio epitelial) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región luminal: Permite la reabsorción de Na⁺ desde el lumen hacia las células principales.
  - Canal medular renal externo de potasio en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la porción luminal: Permite la excreción de K⁺ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la orina.
- La aldosterona estimula la reabsorción de Na⁺ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria túbulos renales:
  - El agua sigue al AL Amyloidosis Na⁺.
  - Crea un gradiente eléctrico negativo a través del lumen, promoviendo la secreción de K⁺ y H⁺ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la orina.
Resultados de los LOS Neisseria antagonistas de la aldosterona:
- ↓ En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la reabsorción de Na⁺ → el agua permanece en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el lumen tubular con el Na⁺ → diuresis.
- ↓ Excreción de K⁺ → ahorro de potasio
- ↓ Excreción de H⁺ → tendencia a la acidosis Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are respiratory acidosis and metabolic acidosis, due to metabolic acid build up. Respiratory Acidosis metabólica
Efectos antiandrogénicos:
- Espironolactona (efectos antiandrogénicos significativos):
  - Los LOS Neisseria antagonistas de los LOS Neisseria receptores de mineralocorticoides no selectivos, que también pueden unirse a los LOS Neisseria receptores de estrógeno y progesterona, → pueden ↑ la aromatización de la testosterona a estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins.
  - ↓ Producción de testosterona
  - Se une a los LOS Neisseria receptores de andrógenos e inhibe competitivamente la testosterona y la dihidrotestosterona.
  - Puede ayudar a mejorar el acné, pero también provoca ginecomastia, impotencia, disminución de la libido e irregularidades menstruales.
- Eplerenona:
  - Más selectiva para el receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors mineralocorticoide, con muchos menos efectos antiandrogénicos
  - Es mucho mejor tolerada.
Efectos antiinflamatorios ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum dosis bajas de eplerenona):
- ↓ Defectos de perfusión miocárdica tras un IM → ↓ mortalidad cardíaca
- Puede frenar la progresión de la albuminuria Albuminuria The presence of albumin in the urine, an indicator of kidney diseases. Kidney Function Tests en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes diabéticos.

Bloqueadores de los LOS Neisseria canales de sodio (triamtereno, amilorida):

Cationes que se unen y bloquean directamente los LOS Neisseria ENaCs en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la región apical de las células que recubren los LOS Neisseria túbulos contorneados distales y los LOS Neisseria conductos colectores.
Resulta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum:
- ↓ Reabsorción de Na⁺
- ↓ Excreción de K⁺
- El agua siempre sigue al AL Amyloidosis Na⁺ → el agua permanece con el Na⁺ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria túbulos ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lugar de reabsorberse).
Efectos fisiológicos:
- La diuresis es el resultado del efecto osmótico del Na⁺ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria túbulos.
- No hay pérdida significativa de potasio.

Mechanism of action of aldosterone antagonists and sodium channel blockers — Mecanismo de acción de los antagonistas de la aldosterona y los bloqueadores de los canales de sodio
Imagen por Lecturio.

Farmacocinética

Absorción:
- Todos se absorben bien por vía oral.
- El efecto máximo se produce a las 2–4 horas aproximadamente.
Metabolismo:
- La espironolactona y el triamtereno se metabolizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum metabolitos activos.
- La eplerenona se metaboliza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum metabolitos inactivos.
- La amilorida no se metaboliza hepáticamente.
Excreción: principalmente por los LOS Neisseria riñones; secundariamente por la bilis/heces

Tabla: Farmacocinética de los LOS Neisseria diuréticos ahorradores de potasio
Medicamento	Absorción	Distribución	Metabolismo	Excreción
Espironolactona	Biodisponibilidad: aproximadamente el 90% cuando se toma con alimentos Efecto máximo: aproximadamente 2,5–4 horas	Unión a proteínas: > 90%	Metabolismo hepático rápido y extenso a metabolitos activos	Orina (principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum forma de metabolitos) Bilis (secundaria)
Eplerenona	Biodisponibilidad: aproximadamente el 70% Efecto máximo: 2 horas	VD: 42–90 L Unión a proteínas: 50%	Metabolismo hepático por CYP3A4 CYP3A4 Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers) a metabolitos inactivos	Orina (67%) Heces (32%) Vida media: 3–6 horas
Triamtereno	Se absorbe rápidamente. Biodisponibilidad: 50% Efecto máximo: 3 horas	VD: 1,5 L/kg	Metabolismo hepático por CYP1A2 a metabolitos activos	Se excreta por vía renal.
Amilorida	Se absorbe rápidamente. Efecto máximo: 3–4 horas	VD: 350–380 L Unión a proteínas: mínima	No se metaboliza.	Orina (50%) Heces (40%) Vida media: 6–9 horas

VD: volumen de distribución

Indicaciones

Indicaciones generales

Los LOS Neisseria diuréticos ahorradores de potasio son los LOS Neisseria más útiles para tratar el edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema relacionado con estados de exceso de mineralocorticoides, que pueden ser primarios o secundarios. Las indicaciones incluyen:

Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema por causas primarias de exceso de mineralocorticoides:
- Síndrome de Conn
- Producción ectópica de la hormona adrenocorticotrópica (ACTH, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)
Edemas debidos a estados de disminución del volumen intravascular, que resultan de un exceso secundario de mineralocorticoides:
- Insuficiencia cardíaca/post-IM (especialmente eplerenona)
- Cirrosis
- Síndrome nefrótico
- Hipertensión resistente (normalmente además de los LOS Neisseria antihipertensivos de 1.ra línea)

Indicaciones únicas de la espironolactona

La espironolactona tiene indicaciones adicionales debido a sus propiedades antiandrogénicas:

Estados de hiperandrogenismo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las mujeres, incluyendo:
- Acné vulgar
- Hirsutismo
- Síndrome de ovario poliquístico
- Hiperplasia suprarrenal congénita
Terapia hormonal para mujeres transgénero (hombre a mujer)

Efectos Secundarios y Contraindicaciones

Efectos secundarios de los LOS Neisseria diuréticos ahorradores de potasio

Alteraciones en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum fluidos y electrolitos:
- Hiperpotasemia (↑ K⁺)
- Acidosis Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are respiratory acidosis and metabolic acidosis, due to metabolic acid build up. Respiratory Acidosis metabólica hiperclorémica
- Hiponatremia (↓ Na⁺)
- Hipomagnesemia (↓ Mg²⁺)
- Hipocalcemia (↓ Ca CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)²⁺)
- Hipovolemia
Síntomas:
- Mareos
- Cefalea
- Calambres musculares
- Malestar gastrointestinal: cólicos abdominales, náuseas, vómitos, diarrea
- Fotosensibilidad (triamtereno)
Efectos adicionales específicos de la espironolactona (relacionados con sus propiedades antiandrogénicas):
- Ginecomastia
- Impotencia y ↓ libido
- Anomalías menstruales

Contraindicaciones

Hiperpotasemia
Enfermedad de Addison/insuficiencia suprarrenal
Anuria Anuria Absence of urine formation. It is usually associated with complete bilateral ureteral (ureter) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present. Acute Kidney Injury o ERC severa/progresiva
Enfermedad hepática grave
Embarazo (especialmente los LOS Neisseria antagonistas de la aldosterona, que pueden causar la feminización del feto masculino)

Precauciones

Diabetes Diabetes Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and dysfunction of the regulation of glucose metabolism by insulin. Type 1 DM is diagnosed mostly in children and young adults as the result of autoimmune destruction of β cells in the pancreas and the resulting lack of insulin. Type 2 DM has a significant association with obesity and is characterized by insulin resistance. Diabetes Mellitus (especialmente triamtereno y amilorida)
Gota
Lactancia

Comparación de Medicamentos

Algunos de los LOS Neisseria otros diuréticos más comunes son los LOS Neisseria diuréticos tiazídicos (e.g., la hidroclorotiazida), los LOS Neisseria diuréticos de asa ASA Anterior Cord Syndrome (e.g., la furosemida), los LOS Neisseria inhibidores de la anhidrasa carbónica (e.g., la acetazolamida) y los LOS Neisseria diuréticos osmóticos (e.g., el manitol).

Tabla: Comparación de los LOS Neisseria diuréticos
Medicamento	Mecanismo	Efecto fisiológico	Indicación
Diurético tiazídico: Hidroclorotiazida	↓ Reabsorción de NaCl en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el DCT a través de la inhibición del cotransportador de Na⁺/Cl^–	↓ Presión arterial ↓ Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema	Hipertensión Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
Diurético de asa ASA Anterior Cord Syndrome: Furosemida	Inhibe el cotransportador luminal de Na⁺/K⁺/Cl^– en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la rama ascendente gruesa del asa ASA Anterior Cord Syndrome de Henle.	↓ Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema ↓ Presión arterial	Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema/ascitis Insuficiencia cardíaca Hipertensión
Diurético ahorrador de potasio: Espironolactona	↓ Reabsorción de Na a través de los LOS Neisseria canales ENaC ENaC Sodium channels found on salt-reabsorbing epithelial cells that line the distal nephron; the distal colon; salivary ducts; sweat glands; and the lung. They are amiloride-sensitive and play a critical role in the control of sodium balance, blood volume, and blood pressure. Liddle Syndrome en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo colector Inhibición de los LOS Neisseria receptores de aldosterona en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el túbulo colector	↓ Presión arterial ↓ Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema No causa ↑ excreción de K⁺. Efectos antiandrogénicos	Insuficiencia cardíaca Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema/ascitis Hipertensión Hirsutismo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las mujeres Hiperaldosteronismo primario
Inhibidor de la anhidrasa carbónica: Acetazolamida	Inhibe tanto la hidratación del CO₂ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células epiteliales del PCT como la deshidratación del H₂CO₃ en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el lumen del PCT; provocando una excreción ↑ HCO₃^–y Na⁺.	↑ Excreción urinaria de HCO₃^– → acidosis Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are respiratory acidosis and metabolic acidosis, due to metabolic acid build up. Respiratory Acidosis metabólica. ↓ Presión intraocular	Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con alcalosis metabólica Enfermedad de las alturas ↑ Presión intraocular Uso fuera de indicación: hidrocefalia de presión normal
Diuréticos osmóticos: Manitol	↑ Presión osmótica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el filtrado glomerular → ↑ líquido tubular e impide la reabsorción de agua.	↓ Agua libre ↓ Volumen sanguíneo cerebral	Aumento de la presión intracraneal Aumento de la presión intraocular

PCT: túbulo contorneado proximal, por sus siglas en inglés
DCT: túbulo contorneado distal, por sus siglas en inglés

Diuréticos — Sitios de acción, dentro de la nefrona, para las clases de medicamentos diuréticos
Imagen por Lecturio. Licencia: CC BY-NC-SA 4.0

Referencias

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