Angioedema

Descripción General

Definición

• El angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema es un edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema localizado, autolimitado (pero potencialmente mortal), sin fóvea y asimétrico que se produce en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las capas profundas de la piel y el tejido mucoso.
• Puede ocurrir con o sin urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives):
  • Con urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives): indica una reacción de hipersensibilidad de tipo I mediada por IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions
  • Sin urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives): mediada por sustancias distintas a la IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions, generalmente bradicinina
• Aguda o crónica:
  • Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema agudo: < 6 semanas de duración
  • Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema crónico: 2–3 episodios por semana durante ≥ 6 semanas de duración

Epidemiología

• Incidencia:
  • Los LOS Neisseria datos sobre la incidencia global son limitados.
  • Relativamente común
  • Ocurre en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 40%–50% de los LOS Neisseria pacientes con urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives) crónica
  • Aproximadamente 10%–20% de las personas experimentarán un episodio de angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algún momento.
• Rango de edad:
  • Ocurre en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cualquier grupo de edad
  • ↑ Incidencia después de la adolescencia (máxima a los LOS Neisseria 20–30 años)
• No hay sesgo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum referencia al AL Amyloidosis sexo
• Más comúnmente visto en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum afroamericanos

Etiología y Fisiopatología

Clasificación

El angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema puede ser el resultado de 3 mecanismos principales:

• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por mastocitos (el más común y asociado a la urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives)):
  • Los LOS Neisseria mastocitos se activan por:
    • IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions a antígenos específicos
    • Estímulos físicos
    • Medicamentos (activación directa de los LOS Neisseria mastocitos no mediada por IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions)
  • Una vez activados, los LOS Neisseria mastocitos liberan mediadores inflamatorios:
    • Histamina
    • Leucotrienos
    • Prostaglandinas
    • Heparina
• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por bradicinina (no asociado a urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives)):
  • La bradicinina es un mediador inflamatorio que puede provocar vasodilatación y permeabilidad vascular.
  • ↑ Bradicinina → ↑ vasodilatación y ↑ permeabilidad vascular.
  • Debido a:
    • ↓ inhibidor de C1 → ↓ inhibición de la generación de cinina → ↑ bradicinina.
    • ↑ Inhibición de la enzima convertidora de angiotensina → ↓ degradación de la bradicinina → ↑ bradicinina
• Mecanismo idiopático o desconocido

Fisiopatología general

• Mediadores inflamatorios → ↑ permeabilidad vascular y dilatación de capilares y vénulas
• Extravasación del líquido de la irrigación → edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema asimétrico en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tejido subcutáneo y la dermis Dermis A layer of vascularized connective tissue underneath the epidermis. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are sweat glands; hair follicles; and sebaceous glands. Skin: Structure and Functions profunda:
  • Se produce en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las zonas de la irrigación afectada
  • No depende de la gravedad

Etiologías mediadas por mastocitos

El angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por mastocitos suele ir asociado a la urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives).

• IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions a antígenos específicos (reacciones de hipersensibilidad de tipo I):
  • Polen y moho
  • Los LOS Neisseria alimentos, más comúnmente:
    • Cacahuetes
    • Nueces de árbol
    • Mariscos
    • Lácteos
    • Huevos
  • Medicamentos:
    • Penicilina
    • Medicamentos con sulfa
    • AINE
  • Medio ambiente:
    • Picaduras de insectos (veneno) y mordeduras
    • Látex
  • Estímulos físicos:
    • Frío
    • Calor Calor Inflammation
    • Ejercicio
    • Vibraciones
    • Presión
• Medicamentos (estimulan directamente los LOS Neisseria mastocitos sin IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions):
  • Opioides
  • AINE
    • Más comúnmente debido a la aspirina
    • Nota: Tanto la alergia mediada por IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions como la estimulación directa de los LOS Neisseria mastocitos son posibles.
  • Agentes de radiocontraste

Etiologías mediadas por bradicinina

Estas etiologías no se asocian a la liberación de histamina ni a la urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives).

• Inhibidor C1 disfuncional:
  • Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema hereditario: una anomalía autosómica dominante en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cantidad o función del inhibidor C1
  • Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema adquirido por deficiencia de inhibidor C1: desarrollo de anticuerpos contra el inhibidor C1
• Medicamentos (ambas vía ↓ degradación de la bradicinina):
  • Inhibidores de la enzima convertidora de angiotensina (IECA)
  • Inhibidores de la dipeptidil peptidasa-4

Otras etiologías

• La urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives) puede estar presente o no.
• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema idiopático:
  • No se determina una etiología tras una evaluación exhaustiva.
  • Comúnmente asociado con el angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema crónico
• Otras causas de angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema con mecanismos desconocidos:
  • Infecciones:
    • Resfriado común
    • Faringitis estreptocócica
    • Infecciones del tracto urinario
  • Bloqueadores de los LOS Neisseria canales de calcio
  • Otros medicamentos o hierbas medicinales (poco frecuentes)

Presentación Clínica

• Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema del tejido cutáneo y mucoso profundo:
  • Cara
  • Labios, boca, lengua
  • Garganta, laringe y úvula
  • Extremidades
  • Genitales
  • Pared intestinal:
    • Dolor Dolor Inflammation abdominal tipo cólico
    • Náuseas y vómitos
    • Diarrea
• Características del edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema:
  • Inicio:
    • Mediado por los LOS Neisseria mastocitos: de minutos a horas
    • Mediado por la bradicinina: de horas a días
  • Resolución espontánea (de horas a días)
  • Distribución asimétrica
  • Se forma en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum zonas no dependientes de la gravedad
• Urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives) (solo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum casos mediados por mastocitos)
  • Ronchas coalescentes y bien circunscritas
  • Intensamente pruriginoso
  • Eritematosa
  • Edematosa
  • Bordes elevados
  • Escaldado central
• Anafilaxia:
  • Inflamación de la garganta y de las vías respiratorias que pone en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum peligro la vida → deterioro del flujo de aire
  • Signos y síntomas:
    • Dificultad para respirar
    • Sibilancias y estridor
    • Taquicardia
    • Hipotensión

Diagnóstico

El diagnóstico del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema suele ser clínico, pero las pruebas pueden ayudar a aclarar la etiología. La mayoría de los LOS Neisseria casos de angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema crónico son idiopáticos.

• Aspectos importantes de la anamnesis:
  • Exposición reciente a alérgenos
  • Picaduras o mordeduras
  • Antecedentes de medicamentos
• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por mastocitos con urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives):
  • Hemograma completo con diferencial:
    • Posible eosinofilia
    • Recuento normal de leucocitos
  • Con anafilaxia: ↑ de la triptasa confirma la activación de mastocitos
  • Pruebas cutáneas de alergia
  • Cese de un medicamento
  • Repetir los LOS Neisseria estímulos físicos (si se sospecha que hay un evento desencadenante).
  • Anticuerpos IgE IgE An immunoglobulin associated with mast cells. Overexpression has been associated with allergic hypersensitivity. Immunoglobulins: Types and Functions en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum suero contra antígenos específicos
• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema aislado sin urticaria Urticaria Urticaria is raised, well-circumscribed areas (wheals) of edema (swelling) and erythema (redness) involving the dermis and epidermis with associated pruritus (itch). Urticaria is not a single disease but rather is a reaction pattern representing cutaneous mast cell degranulation. Urticaria (Hives):
  • ↑ PCR PCR Polymerase chain reaction (PCR) is a technique that amplifies DNA fragments exponentially for analysis. The process is highly specific, allowing for the targeting of specific genomic sequences, even with minuscule sample amounts. The PCR cycles multiple times through 3 phases: denaturation of the template DNA, annealing of a specific primer to the individual DNA strands, and synthesis/elongation of new DNA molecules. Polymerase Chain Reaction (PCR) → infección, angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema inducido por IECA.
  • ↓ Proteína del complemento C4 → evaluar por angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema hereditario o deficiencia adquirida del inhibidor C1:
    • Antígeno inhibidor C1
    • Niveles de función del inhibidor C1

Tratamiento

Tratamiento general

• Evaluar vía aérea → intubar si hay signos de compromiso de la vía aérea
• Evaluar si hay anafilaxia → estabilizar si está presente:
  • Epinefrina
  • Líquidos intravenosos
  • Oxígeno
• Suspender cualquier medicamento potencialmente desencadenante.

Tratamiento del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por mastocitos

• Identificar y eliminar los LOS Neisseria desencadenantes.
• Antihistamínicos H1 (1ra línea): para suprimir la histamina liberada por los LOS Neisseria mastocitos:
  • Difenhidramina
  • Cetirizina
  • Loratadina
• Glucocorticoides sistémicos:
  • Metilprednisolona
  • Prednisona
  • Prednisolona

Tratamiento del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema mediado por bradicinina

• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema hereditario:
  • Opciones de 1ra línea para intentar ↓ la bradicinina:
    • Concentrado de inhibidor C1 purificado
    • Inhibidor de la calicreína: ecalantida
    • Antagonista del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors B2 de la bradicinina: icatibant
  • Opciones de segunda línea:
    • Plasma Plasma The residual portion of blood that is left after removal of blood cells by centrifugation without prior blood coagulation. Transfusion Products fresco congelado
    • Sólo se utiliza cuando las opciones de primera línea no están disponibles
• Angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema asociado a los LOS Neisseria IECA:
  • Pueden utilizarse las terapias mencionadas anteriormente para angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema, pero su eficacia no está demostrada.
  • La mayoría de los LOS Neisseria casos se resuelven 24–72 horas después de suspender el IECA.

Tratamiento del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema crónico idiopático

• Los LOS Neisseria pacientes deben ser remitidos a un especialista en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum alergias.
• Terapia médica:
  • Antihistamínicos no sedantes:
    • Cetirizina
    • Loratadina
  • Se puede añadir un antagonista de los LOS Neisseria receptores de leucotrienos ( montelukast Montelukast Asthma Drugs).
  • Para episodios agudos:
    • Prednisona
    • Difenhidramina

Diagnóstico Diferencial

• Dermatitis Dermatitis Any inflammation of the skin. Atopic Dermatitis (Eczema) de contacto: inflamación de la piel en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum respuesta a irritantes de contacto, que puede afectar a la cara en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algunas circunstancias (a menudo cosméticos o productos farmacéuticos tópicos). Puede aparecer edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema y prurito imitando un angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema. La microvesiculación (formación de pequeñas vesículas), el dolor Dolor Inflammation y la sensación de ardor pueden ayudar a distinguir la dermatitis Dermatitis Any inflammation of the skin. Atopic Dermatitis (Eczema) de contacto del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema. El tratamiento consiste en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum eliminar el agente agresor y reducir la inflamación de la piel con esteroides o inhibidores tópicos de la calcineurina.
• Celulitis y erisipela: infecciones cutáneas que se presentan con eritema bien delimitado, edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema y calor Calor Inflammation. La celulitis afecta a la dermis Dermis A layer of vascularized connective tissue underneath the epidermis. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are sweat glands; hair follicles; and sebaceous glands. Skin: Structure and Functions más profunda y a la grasa subcutánea, mientras que la erisipela afecta a la dermis Dermis A layer of vascularized connective tissue underneath the epidermis. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are sweat glands; hair follicles; and sebaceous glands. Skin: Structure and Functions superficial. La celulitis y la erisipela suelen ir acompañadas de fiebre, son más dolorosas que el angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema y tienen una demarcación más pronunciada que éste. El diagnóstico es clínico y el tratamiento es con antibióticos.
• Afecciones autoinmunes: lupus eritematoso sistémico, polimiositis, dermatomiositis y síndrome de Sjogren, que pueden presentarse con edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema de la cara, áreas periorbitales y manos. La presencia de otros hallazgos (e.g., el fenómeno de Raynaud, la sequedad de ojos/boca y las erupciones características) diferencian las afecciones autoinmunes del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema. El diagnóstico se basa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria hallazgos clínicos y en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las pruebas de anticuerpos. El tratamiento varía, pero suele incluir esteroides e inmunosupresores.
• Síndrome de la vena cava superior: tumores que afectan al AL Amyloidosis pulmón derecho, a los LOS Neisseria ganglios linfáticos o a las estructuras mediastínicas y que pueden obstruir el flujo sanguíneo a través de la vena cava superior por invasión directa o compresión externa, provocando hinchazón en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cara o el cuello y disnea. Otros síntomas (e.g., dolor Dolor Inflammation torácico, respiratorio o neurológico) ayudan a distinguir el síndrome de vena cava superior del angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema. El diagnóstico se realiza con imagenología y venografía. El tratamiento incluye el tratamiento de la malignidad y las técnicas para aliviar la obstrucción.