El músculo liso se encuentra principalmente enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las paredes de las estructuras huecas y algunos órganos viscerales, incluidas las paredes de losLOSNeisseria tractos vascular, gastrointestinal, respiratorio y genitourinario. El músculo liso se contrae más lentamente y se regula de manera diferente que el músculo esquelético. El músculo liso puede ser estimulado por impulsos nerviosos, hormonas, factores metabólicos (como niveles de pHpHThe quantitative measurement of the acidity or basicity of a solution.Acid-Base Balance, CO2 u O2), su propia capacidad intrínseca de marcapasos o incluso estiramiento mecánico. Cualquiera que sea el estímulo, da como resultado un aumento enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria niveles de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) sarcoplásmico. Este CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) resulta enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum una fosforilación de la miosina, que la activa, permitiendo que la miosina interactúe con la actina. EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso, la actina se une a las proteínas del citoesqueleto ubicadas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum todo el sarcoplasma y la membrana celular, conocidas como cuerpos densos. Por lo tanto, cuando la miosina tira de la actina, la actina tira de losLOSNeisseria cuerpos densos, haciendo que toda la célula se “aplaste” y se contraiga.
Localización, Funciones y Patrones de Contracción del Músculo Liso
Características generales del músculo liso
Músculo no estriado (i.e., sin estrías enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el microscopio)
Músculos involuntarios que generalmente controlan losLOSNeisseria órganos internos y losLOSNeisseria vasos
Inervado por el sistema nervioso autónomo (SNA)
Localizaciones
El músculo liso se encuentra principalmente enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las paredes de estructuras huecas y algunos órganos viscerales, que incluyen:
Vasos sanguíneos
Tracto gastrointestinal:
Esófago
Estómago
Intestino delgado y grueso
Recto
Esfínteres
Tracto respiratorio:
Tráquea
Bronquios y bronquiolos
Aparato reproductor femenino:
Útero
Trompas de Falopio
VaginaVaginaThe vagina is the female genital canal, extending from the vulva externally to the cervix uteri internally. The structures have sexual, reproductive, and urinary functions and a rich blood supply, mainly arising from the internal iliac artery.Vagina, Vulva, and Pelvic Floor: Anatomy
Tracto urinario:
Uréteres
Vejiga urinaria
Uretra
Iris del ojo
Músculos piloerectores enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria folículos pilosos
Funciones
Controlar el diámetro de estructuras huecas o aberturas (e.g., vasos sanguíneos, vías respiratorias, esfínteres, pupilas)
Provocar movimiento a través de estructuras huecas (e.g., tracto gastrointestinal, trompas de Falopio)
Expulsión (e.g., orina de la vejiga, feto del útero)
Tabla: Localizaciones y funciones de losLOSNeisseria músculos lisos
Localización
Función
Vasos sanguíneos
Controlar el diámetro, regularRegularInsulin el flujo sanguíneo
Vías respiratorias pulmonares
Controlar el diámetro, regularRegularInsulin el flujo de aire
Sistema urinario
Impulsar la orina a través del uréter, tono de la vejiga, esfínter interno
Tracto reproductor masculino
Secreción, impulsar el semen
Tracto reproductor femenino
Propulsión (trompas de Falopio), parto (miometrio uterino)
Ojo
Control del diámetro de la pupila (músculo del iris) y forma del cristalino (músculo ciliar)
Riñón
RegularRegularInsulin el flujo sanguíneo (células mesangiales)
Piel
Erección del pelo (músculos piliPiliFilamentous or elongated proteinaceous structures which extend from the cell surface in gram-negative bacteria that contain certain types of conjugative plasmid. These pili are the organs associated with genetic transfer and have essential roles in conjugation. Normally, only one or a few pili occur on a given donor cell. This preferred use of ‘pili’ refers to the sexual appendage, to be distinguished from bacterial fimbriae, also known as common pili, which are usually concerned with adhesion.Salmonella)
Patrones de contracción, relajación y estados de reposo
Según la función, el músculo liso de diferentes tejidos estará enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum diferentes estados de contracción enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum reposo.
Normalmente contraído:
Músculos que normalmente están contraídos y se relajan cuando se estimulan
Ejemplo: esfínteres
Normalmente relajado:
Músculos que normalmente están relajados y se contraen cuando son estimulados
Ejemplos: vejiga, útero
Normalmente parcialmente contraído (músculo con tono de reposo):
Músculos que se encuentran enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum estados de contracción parcial, con la capacidad de contraerse o relajarse más dependiendo del estímulo
Ejemplos: vasos sanguíneos, vías respiratorias
Músculos normalmente activos:
Músculos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum movimiento bastante constante
Ejemplo: músculos lisos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el tracto gastrointestinal
Patrones de contracción y relajación para diferentes tipos de músculo liso
Hay 2 tipos principales de tejido muscular liso: tipos de una sola unidad y de unidades múltiples.
Tipo de unidad individual
LosLOSNeisseria músculos lisos de tipo una sola unidad también se denominan unidades fásicas:
LosLOSNeisseria miocitos están eléctricamente acoplados entre sí a través de unionescomunicantes:
Transmite impulsos a losLOSNeisseria miocitos adyacentes → produce un sincitio funcional (un gran número de células que se contraen como una sola unidad)
Permite una contracción lenta y ondulatoria
Se encuentra enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria vasos sanguíneos y enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la mayoría de losLOSNeisseria órganos viscerales, incluidos losLOSNeisseria del tracto digestivo, respiratorio, urinario y reproductivo
Más común que el tipo de unidades múltiples
A menudo forma múltiples capas (e.g., capas circulares y longitudinales enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el tracto gastrointestinal)
Tipo de unidad múltiple
LosLOSNeisseria músculos lisos del tipo de unidades múltiples también se denominan unidades tónicas:
Las células individuales están separadas por una membrana basal.
Faltan uniones comunicantes
Cada célula está inervada por su propia fibra nerviosa → las células se contraen independientemente unas de otras
Encontrado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum:
Arterias más grandes y conductos pulmonares
Músculos piloerectores de losLOSNeisseria folículos pilosos
Iris del ojo
Los tipos de músculo liso de una sola unidad contienen más uniones comunicantes, lo que permite un patrón de contracción más continuo, como en los músculos que controlan el estómago. Los tipos de músculo liso de unidades múltiples son fibras únicas con uniones comunicantes mínimas, lo que da como resultado células que se contraen individualmente.
Imagen: “Smooth muscle tissue is found around organs in the digestive, respiratory and reproductive tracts and the iris of the eye” por OpenStax College. Licencia: CC BY 4.0, recortado por Lecturio
Estimulación de las Células Musculares Lisas
Posibles estímulos
EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo esquelético, el estímulo para que una fibra muscular se contraiga siempre proviene de una neurona motora. Sin embargo, el músculo liso puede estimularse de diversas formas.
Estimulación a través del SNA
Acetilcolina
Norepinefrina
Acoplamiento con otras células musculares lisas a través de uniones comunicantes
Capacidad intrínseca de marcapasos: ciertas células enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el tracto gastrointestinal
Hormonas:
Epinefrina/norepinefrina circulante (liberada por la médula suprarrenal)
Oxitocina
Histamina
Factores metabólicos:
Niveles de CO2
Niveles de O2
Niveles de pHpHThe quantitative measurement of the acidity or basicity of a solution.Acid-Base Balance
Estiramiento mecánico
Uniones difusas
Para el músculo liso que se estimula a través del SNA, losLOSNeisseria neurotransmisores se liberan de losLOSNeisseria nervios enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosumlas uniones difusas (enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum lugar de enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum una unión neuromuscular que se encuentra enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo esquelético).
Varicosidades: abultamientos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum forma de cuentas a lo largo de la fibra nerviosa autónoma que contienen vesículas sinápticas con neurotransmisores
Las fibras nerviosas pasan y corren entre múltiples miocitos diferentes.
LosLOSNeisseria neurotransmisores se liberan de las várices → estimulan losLOSNeisseria receptores, que se encuentran enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum toda la superficie de la célula muscular
Unión difusa:
Describe la unión entre una varicosidad y losLOSNeisseria receptores enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la superficie de la célula del músculo liso
Una sola fibra nerviosa puede tener múltiples uniones difusas diferentes, con múltiples células musculares lisas diferentes
Acoplamiento Excitación–Contracción en el Músculo Liso
AlALAmyloidosis igual que el músculo esquelético, el músculo liso requiere una entrada de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el sarcoplasma para iniciar una contracción. El músculo liso, sin embargo, utiliza diferentes procesos para lograr esta afluencia de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+: liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) y liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) mediada por ligando.
Liberación de calcio inducida por calcio
Canales involucrados:
Canales de liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts):
Localizados enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico con la célula muscular
Cuando están abiertos, losLOSNeisseria canales de liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) permiten la salida de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ desde el retículo sarcoplásmico hacia el sarcoplasma.
Estimulados para abrirse por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ (enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el lado del sarcoplasma)
Canales de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) tipo L:
Canales de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) ligados a la membrana y dependientes de voltaje
Localizados enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum pequeñas invaginaciones enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el sarcolema denominadas caveolas
Localizados muy cerca de losLOSNeisseria canales de liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico
Proceso de liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts):
Un estímulo cambia el potencial de membrana del sarcolema.
Esto abre losLOSNeisseria canales de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) tipo L.
Pequeñas cantidades de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ entran enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la célula.
Este CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ activa losLOSNeisseria canales de liberación de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) inducida por CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico para que se abran.
Hay una gran salida de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ del retículo sarcoplásmico.
El CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ provoca la unión de actina–miosina.
Liberación de Ca inducida por calcio (CICR): un estímulo hace que se abran los canales de Ca de tipo L dependientes de voltaje en la superficie celular, lo que permite que entren pequeñas cantidades de Ca en la célula. Este Ca desencadena la apertura de los canales CICR en el retículo sarcoplásmico (SR), lo que permite una gran salida de Ca desde el SR hacia el sarcoplasma. Este Ca permite que ocurra la unión de actina–miosina y la contracción muscular. Una ATPasa de Ca bombea el Ca de vuelta al RS durante la relajación.
Imagen por Lecturio.
Liberación de calcio mediada por ligando
Un estímulo activa una proteína unida a la membrana.
La proteína unida a la membrana genera un 2do mensajero intracelular.
El 2do mensajero estimula un canal activado por ligando enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico para abrir → salida de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+
Ejemplo común:
El estímulo activa un receptorReceptorReceptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell.Receptors acoplado a proteína G
El receptorReceptorReceptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell.Receptors acoplado a proteína G activa la fosfolipasa C.
La fosfolipasa C escinde el fosfatidilinositol-4,5-bisfosfato para producir:
Trifosfato de inositol: funciona como 2do mensajero enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum este caso
Diacilglicerol
El trifosfato de inositol se une a un canal activado por trifosfato de inositol enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico → el canal se abre, lo que permite la salida de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+
Liberación de calcio mediada por ligando: aquí, un estímulo activa un receptor acoplado a proteína G (GPCR), que activa la fosfolipasa C (PLC). Luego, el PLC genera trifosfato de inositol (IP3), que se une a un canal activado por ligando de IP3 en el retículo sarcoplásmico (SR), abriendo el canal y permitiendo la salida de Ca hacia el sarcoplasma. Este Ca da como resultado la unión de actina–miosina y la contracción muscular.
Imagen por Lecturio.
Cómo el CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) intracelular conduce a la interacción actina–miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso
El músculo estriado se regula mediante cambios enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las proteínas reguladoras de actina, mientras que el músculo liso se regula mediante la fosforilación de la miosina.
EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo esquelético:
El complejo troponina–tropomiosina cubre losLOSNeisseria sitios de unión de la miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la actina, evitando la interacción actina–miosina.
El CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) provoca un cambio conformacional enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el complejo troponina–tropomiosina.
Este cambio conformacional revela losLOSNeisseria sitios de unión de la miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la actina → la actina y la miosina pueden interactuar
Un adenosin trifosfato (ATP, por sus siglas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés) se une a la cabeza de miosina y puede comenzar el ciclo del puente cruzado (lo que conduce a la contracción muscular).
EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso:
El CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ intracelular enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el sarcoplasma se une a la calmodulina.
La calmodulina es una enzima que activa la quinasa de cadena ligera de miosina.
La quinasa de cadena ligera de miosina transfiere un fosfato del ATP a la miosina.
La miosina fosforilada activa la miosina ATPasa dentro de la miosina.
La miosina ahora puede interactuar con la actina.
Un ATP adicional se une a la cabeza de miosina y puede comenzar el ciclo del puente cruzado (lo que lleva a la contracción muscular).
Miosina fosfatasa:
Inhibe la miosina alALAmyloidosis separar el fosfato requerido para la activación de la miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso
LosLOSNeisseriainhibidores de la miosina fosfatasa ayudan a activar la miosina (porque el inhibidor está inhibido) e incluyen:
Proteína quinasa C
Rho-quinasa
Contracciones graduadas basadas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la cantidad de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) sarcoplásmico:
Más CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) = contracciones más fuertes
Menos CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) = contracciones más débiles
Cómo el calcio intracelular conduce a las interacciones actina–miosina y la contracción muscular en el músculo estriado frente al liso
Disposición de actina y miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso
A diferencia del músculo esquelético, la actina y la miosina no están dispuestas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum sarcómeros enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso. EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso:
La actina está unida a masas de proteínas llamadas cuerpos densos, que están:
Unidos a (y técnicamente parte de) el citoesqueleto
Dispersos por todo el sarcoplasma y enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la cara interna del sarcolema (membrana de la célula muscular)
Conectados entre sí a través de filamentos intermedios
No hay líneas Z que conecten la actina
La miosina se encuentra entre la actina.
La miosina tira de la actina → la actina tira de losLOSNeisseria cuerpos densos → losLOSNeisseria cuerpos densos se acercan unos a otros → la célula muscular entera se encoge = contracción
Estructura de actina (filamentos delgados) y miosina (filamentos gruesos) en el músculo liso
Imagen por Lecturio.
Ciclo de puente cruzado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso
También conocida como la teoría del filamento deslizante de la contracción muscular, el ciclo de puente cruzado es el proceso por el cual la miosina y la actina se mueven entre sí, acortando la célula muscular y provocando la contracción muscular. EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el músculo liso, la miosina debe ser fosforilada por la quinasa de cadena ligera de miosina para que comience el ciclo del puente cruzado.
Proceso:
El ATP se une a la cabeza de miosina.
La miosina ATPasa hidroliza el ATP → adenosin difosfato (ADP, por sus siglas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés):
Mueve la cabeza de miosina a una posición de alta energía “amartillada”
Este movimiento se conoce como golpe de recuperación.
La cabeza de miosina amartillada se une a un sitio de unión de miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la actina, formando un puente cruzado
Golpe de potencia:
La miosina libera ADP y fosfato.
La cabeza de miosina expulsa la energía → vuelve a la posición flexionada, tirando del delgado filamento con ella
Dado que muchas cabezas de miosina están unidas simultáneamente, la actina permanece enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum su nueva posición enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum lugar de “retroceder” a su posición original.
La miosina se une a un nuevo ATP, lo que haceHACEAltitude Sickness que se libere de la actina.
El ciclo vuelve a empezar.
Ciclo de puente cruzado: la quinasa de cadena ligera de miosina (MLCK) fosforila la miosina, activándola. El ATP luego se une a la cabeza de miosina. La miosina ATPasa hidroliza el ATP a ADP y fosfato, y esto mueve la cabeza de miosina a una posición amartillada. Con el ADP y el fosfato aún unidos y la cabeza en posición amartillada, la miosina puede unirse a la actina, formando un puente cruzado. El ADP y el fosfato se liberan, y la energía potencial almacenada se libera, generando el golpe de potencia: la cabeza de miosina vuelve a su posición flexionada, tirando del filamento de actina con ella. El ATP se une a la cabeza de miosina, lo que hace que se libere de la actina y comience el ciclo nuevamente. Este proceso permite que la miosina “camine” a lo largo del filamento de actina, acercando los cuerpos densos entre sí en el músculo liso.
Imagen por Lecturio.
Relajación
La relajación ocurre cuando el CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ es removido del sarcoplasma.
El CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ es removido del sarcoplasma a través de 2 mecanismos:
Movilización del CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ fuera de la célula a través de proteínas de superficie:
CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ ATPasa
Intercambiador Na+–Ca2+
Secuestro de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el retículo sarcoplásmico a través de bombas de Ca-ATPasa de retículo endo/sarcoplásmico
Sin CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+, la miosina es desfosforilada por la miosina fosfatasa → la miosina inactiva ya no puede ejecutar golpes de potencia
Estado del puente de pestillo
Un estado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el que la miosina se desfosforila (ya no puede hacer ciclo de puente cruzado) pero permanece unida a la actina = mantiene algo de tensión
Permite que el músculo mantenga el tono sin gastar mucha energía
Ejemplo: enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum esfínteres, que mantienen la contracción como su estado de “reposo”
El estiramiento puede desencadenar una contracción o una respuesta de tensión-relajaciónenENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum algunos tejidos del músculo liso.
Estiramiento que conduce a la contracción:
Algunos tejidos contienen canales de CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ activados mecánicamente enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el sarcolema
Esto da como resultado un ↑ enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumCaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts)2+ intracelular con estiramiento → conduce a la contracción
Ejemplos: estiramiento enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el esófago o el colonColonThe large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy desencadena contracciones peristálticas
Respuesta estrés-relajación:
Algunos tejidos se contraerán y resistirán el estiramiento brevemente antes de relajarse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum respuesta alALAmyloidosis estiramiento.
Ejemplo: vejiga urinaria
Diferencias entre la Contracción del Músculo Liso y del Músculo Esquelético
Tabla: Diferencias entre estimulación del músculo liso y esquelético
Músculo liso
Músculo esquelético
Estímulo
A través del SNA
Hormonas
Niveles de CO2
Niveles de pHpHThe quantitative measurement of the acidity or basicity of a solution.Acid-Base Balance
Niveles de O2
Estiramiento mecánico
Actividad de marcapasos independiente (e.g., enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el estómago y losLOSNeisseria intestinos)
A través de las neuronas motoras somáticas
Estructura que conecta el nervio con el músculo
Uniones difusas
Uniones neuromusculares
Disposición de actina y miosina
La actina está conectada a losLOSNeisseria cuerpos densos del citoesqueleto.
Dispuestos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum sarcómeros paralelos
Efecto del calcio intracelular
Activa la calmodulina, que activa la quinasa de cadena ligera de miosina, que fosforila la miosina
Se une a la troponina, provocando un cambio conformacional enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el complejo troponina–tropomiosina, que expone losLOSNeisseria sitios de unión a la miosina enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la actina
¿Qué miofilamento está regulado?
Filamento grueso (miosina)
Filamento delgado (actina)
Velocidad de contracción y relajación
Más lento (porque sus bombas de miosina ATPasa y CaCACondylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding.Condylomata Acuminata (Genital Warts) son más lentas)
Squire, JM. (2016). Muscle contraction: Sliding filament history, sarcomere dynamics, and the two Huxleys. Global Cardiology Science & Practice, 2016(2), e201611. https://doi.org/10.21542/gcsp.2016.11
Squire, J. (2019). The actin-myosin interaction in muscle: Background and overview. International Journal of Molecular Sciences, 20(22), 5715. https://doi.org/10.3390/ijms20225715
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