Continuing our discussion of sodium and water
pathophys. Well, we are going to take this
information, stuff that we have seen and really
put onto clinical setting. That at this point
I would say this is more of an advanced type
of application of what we have seen earlier.
But trust me it's not too bad. So two carefully
regulated parameters. Regulated.
We have effective circulating volume. What
does that mean to you? The plasma.
In other words, that is your intravascular
volume, isn't it? And you have tonicity. Tonicity,
of course, representing the osmolarity. Effective
circulating volume is found in the extracellular
fluid. The tonicity is then determined by,
here you go again, serum sodium concentration.
The serum sodium concentration as we discussed
in previous lectures, was the fact that it
is your total body sodium over your total
body water. And we went through all of your
isotonic, hypotonic, hypertonic disorders.
Effective circulating volume, the operative
term here portion of the intravascular volume
that then, of course, perfuses your organs.
Hence, there has to be constant regulation.