Thyroid Hormones: Symptomatology Associated

by Thad Wilson, PhD

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    00:00 So what are some of the problems associated with thyroid hormones.

    00:07 If you have too much or too little thyroid hormones.

    00:11 Well one that the first things to think about is all those myriad of functions that occur with increase in thyroid hormones.

    00:20 A lot of those involve things like the sodium-potassium-ATPase enzymes associated with metabolism.

    00:28 So you can imagine if you have two much thyroid hormone around.

    00:33 Your basic metabolic rate is high.

    00:37 And typically these individuals lose weight because they are hyperthyroid.

    00:43 The opposite is also true.

    00:46 If a person is hypothyroid, their basal metabolism rate is low.

    00:51 And they often times gain weight.

    00:54 Because they don't have the up regulation of all these enzymes associated with metabolism.

    01:00 There are also thermo regulatory issues associated with both hyper and hypo thyroidism.

    01:07 If a person has hyperthyroidism, their BMR is high.

    01:13 And therefore they are producing lot of heat with that extra metabolism.

    01:18 So they are very warm and they need to dissipate that heat.

    01:22 The opposite is true if you have a low BMR with hypothyroidism, often times that person is cold.

    01:31 Because they aren't producing enough metabolic rate and that is what's driving part of that process.

    01:38 Growth can also be effected by thyroid hormones.

    01:42 If you have a lack of thyroid hormones, some of your epithelial plates do not fuse well.

    01:50 And you can have stunted growth.

    01:52 You could also have stunted mental development associated with the lack of thyroid hormone.

    01:59 A couple of very classic symptoms associated with thyroid hormones I'll show you next.

    02:06 Because these are ones that show up on board exams all the time.

    02:10 The first is a Goiter.

    02:13 A goiter is a abnormally large thyroid gland.

    02:18 So this is where the thyroid gland is in the neck.

    02:21 Here though it's much larger than you would expect it to be.

    02:26 If you have a disorder in which there is high amounts of thyroid stimulating hormone, TSH, that stimulates the growth of the thyroid gland.

    02:38 And you can see it can become very large.

    02:41 You can have goiters in both hyper and hypo thyroidism.

    02:47 But it's often times associated with times in which you have very high thyroid stimulating hormone.

    02:55 Another classic symptom that's associated with thyroid hormone abnormalities is an increase in a growth of connective tissue.

    03:07 Specially the basal lamina.

    03:09 This can show up as a place where if you have high petrify of this basal lamina.

    03:16 It can cause things like your eyes to extrude out a little bit.

    03:20 And create things like edema.

    03:23 So this particular disorder will present sometimes in this way.

    03:28 So both the goiter and having these eye protrusions are very classic symptoms of having high thyroid hormones or being hyperthyroid.

    About the Lecture

    The lecture Thyroid Hormones: Symptomatology Associated by Thad Wilson, PhD is from the course Endocrine Physiology.

    Included Quiz Questions

    1. abnormally enlarged thyroid gland.
    2. abnormally enlarged thyroid gland due to increased TSH.
    3. abnormally enlarged thyroid gland due to neoplastic growth.
    4. abnormally enlarged thyroid gland due to increased T3 and T4.
    1. Cold sensitivity
    2. Tachycardia
    3. Weight loss
    4. Increased temperature
    5. Exophthalmos
    1. Poor fusion of epiphyseal plates
    2. Harder bones
    3. Brittle bones
    4. Excessive width to length ratio
    5. Poor calcium deposition pattern

    Author of lecture Thyroid Hormones: Symptomatology Associated

     Thad Wilson, PhD

    Thad Wilson, PhD

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