Thyroid Hormones: Symptomatology Associated

by Thad Wilson, PhD

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    So what are the thyroid hormones that are the most important. We talked about T4. And how they named T4 is that it has 4 iodines on it. T3 only has 3 iodines. There is a reverse T3 in which the three iodines are bound in a little different format. But it is not biologically active. So we mainly talk about T3 and T4 formation. There are few other intermediates. There is a mono-iodinated-tyrosine and a di-iodinated-tyrosine. And these are part of the synthesis process rather than the end hormone. Thyroid hormone synthesis. To be able to synthesis thyroid hormones, you need to make sure you have iodine. Iodine needs to be present in the right place. And that right place is in the colloid. To be able to get it from the blood into the cytosol, we need a specialize transport. That transporter is abbreviated NIS, which is the sodium iodine symporter. It will move these in as co-transported molecules. Now you may ask where does the iodine comes from. It comes from your diet. A person intakes iodine as part of your normal diet. It is one of your required minerals. Now you may have heard that you can have of course iodine deficiencies. This is less likely to occur in many countries. Because we iodinate salt. And if you intake enough salt, usually you'll get enough iodine. For this process though it is a weight limiting step. Mean you need to have a certain amount of iodine in the blood. And you also need to have a thyroid stimulated hormone to engage this particular transporter. So now let's get the iodine through into the cytosol. We have iodine and we're going to talk about it in one form which is called iodide. Iodide is just the singular...

    About the Lecture

    The lecture Thyroid Hormones: Symptomatology Associated by Thad Wilson, PhD is from the course Endocrine Physiology.

    Included Quiz Questions

    1. Goiter
    2. Weight loss
    3. Excess metabolic heat production
    4. Excess long bone growth

    Author of lecture Thyroid Hormones: Symptomatology Associated

     Thad Wilson, PhD

    Thad Wilson, PhD

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