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Sulfonamides, Trimethoprim and Fluoroquinolones – Antimetabolites

by Pravin Shukle, MD
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    About the Lecture

    The lecture Sulfonamides, Trimethoprim and Fluoroquinolones – Antimetabolites by Pravin Shukle, MD is from the course Antimicrobial Pharmacology. It contains the following chapters:

    • Sulfonamides
    • Trimethoprim
    • Sulfamethoxazole/Trimethoprim
    • Flouroquinolones

    Included Quiz Questions

    1. It concentrates in the bladder before being excreted in the urine.
    2. It requires a low pH environment to become activated.
    3. They are also effective against certain fungal infections which are commonly diagnosed in bladder infections.
    4. They are weak acids that must be deprotonated to exert their effect.
    5. Cells of the bladder do not require folate, so there is less organ damage compared to other drugs.
    1. ACE inhibitors
    2. Fluoroquinolones
    3. Tetracyclines
    4. Probenicid
    5. Warfarin
    1. Atypical bacteria
    2. Gram positive cocci
    3. VRSA
    4. MRSA
    5. Anaerobes
    1. Moxifloxacin
    2. Ciprofloxacin
    3. Levofloxacin
    4. Norfloxacin
    5. Oflaxacin
    1. These agents are bacteriostatic.
    2. They have good oral bioavailability.
    3. They work by interfering with DNA topoisomerase II in gram negative organisms.
    4. They are usually administered twice daily.
    5. Kidney excretion of fluroquinolones is blocked by probenecid which may lead to toxic accumulation.

    Author of lecture Sulfonamides, Trimethoprim and Fluoroquinolones – Antimetabolites

     Pravin Shukle, MD

    Pravin Shukle, MD


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