Renin-Angiotensin-Aldosterone-System (RAAS) – Adrenal Cortex

by Carlo Raj, MD

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    What about this RAAS system in aldosterone? Let’s quickly go through the steps here. Let’s say that you have a patient who has decreased blood pressure. Number one, if there’s decreased blood pressure taking place, then as far as profusion is concerned to the kidney in the afferent arteriole, it is depressed. The juxtaglomerular cells via your beta-1 receptors will be releasing rennin, ah, out comes your renin. The renin will then convert the angiotensinogen which is coming from the liver... remember ogen, ogen, ogen is a precursor. Fibrinogen, angiotensinogen, trypsinogen, pepsinogen, those are all ogens. This is angiotensinogen coming from the liver with the help of renin which behaves like an enzyme, you have your angiotensin I. Next, what happens? What’s your… what is your objective here and why would you even want to have angiotensin II and why would you want to have aldosterone? Because your blood pressure is decreased, that is your inciting event, right? Now, the first reflex usually is going to be sympathetic tone, that’s a reflex that occur quickly. The hormone, however, takes a little bit of time. Also, the middle here that you see here, very important physiologic concept of a really quick feedback mechanism is called the MD cells, the macula densa cells that you’ve learned about in physio. All of these amazingly will play a role so that it-it restores blood pressure back towards normal, right? If it’s macula densa, it’s a reflex mechanism and I’m just going to quickly tell you because there’s decreased blood pressure, you have decreased hydrostatic pressure over the glomeruli, therefore decreased filtration, decreased delivery of sodium to the macula densa cells and therefore, what does it want to do with the afferent arteriole to then increase the GFR, the glomerular filtration rate? It wants to...

    About the Lecture

    The lecture Renin-Angiotensin-Aldosterone-System (RAAS) – Adrenal Cortex by Carlo Raj, MD is from the course Adrenal Gland Disorders.

    Included Quiz Questions

    1. Kidneys; liver; lungs/kidneys
    2. Lungs/kidneys; liver; kidneys
    3. Liver; liver; lungs/kidneys
    4. Kidneys; lungs/kidneys; liver
    5. Kidneys; kidneys; liver
    1. Vasoconstriction and increased blood pressure
    2. Breakdown in bradykinin
    3. Conversion of Angiotensinogen
    4. Decreased GFR
    5. Decreased SVR
    1. Increased filtration fraction
    2. Decreased GFR
    3. Decreased BP
    4. Increased sodium retention
    5. Decrease plasma volume
    1. Decreases H+ channels in intercalated cells
    2. Increased K+ excretion
    3. Increased H+ excretion
    4. Increases Na+ channels
    5. Increased Na+/K+ pump in principle cells
    1. ANP
    2. ADH
    3. Aldosterone
    4. Angiotensin II
    5. Renin

    Author of lecture Renin-Angiotensin-Aldosterone-System (RAAS) – Adrenal Cortex

     Carlo Raj, MD

    Carlo Raj, MD

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