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Overview – Antiviral Agents and Treatment of CMV Retinitis – Antiviral Drugs

by Pravin Shukle, MD
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    00:00 So just as an overview I have here a list of the different agents and which viruses they are particularly active against.

    00:09 And I've listed the primary versus the secondary drugs.

    00:12 So in cyctomegalovirus, the primary drugs are ganciclovir, HSV and VZV.

    00:19 Acyclovir is a primary drug.

    00:21 And hepatitis B virus interferon alpha is a very, very effective treatment.

    00:27 Also hepatitis C we tend to use a lot of interferon alpha.

    00:33 Influenza A, you're probably quite familiar with this agent.

    00:37 You may even have taken it yourself.

    00:39 And also influenza B, it's also quite active as well.

    00:46 Now we're going to talk about some specialized treament issues.

    00:52 Let's talk about CMV retinitis.

    00:54 So we will also cover this in the opthamology portions of our lectures.

    01:00 But just to get the idea of these agents now, in terms of sight threatening lesions that are often found adjacent.

    01:07 For example, to the optic nerve or to the fovea, we will use intravitreal injections of ganciclovir.

    01:14 Sometimes we'll use intravitreal infection of foscarnet as well.

    01:19 Now these are obviously administered by an opthamologist.

    01:23 Now for systemic cytomegalovirus therapy we may use valganciclovir which is -- sorry valganciclovir which is used orally twice a day for up to three weeks.

    01:36 Alternatives include ganciclovir.

    01:39 So intravitreal and systemic therapies are a little bit different.

    01:44 So remember the intravitreal injections are exceedingly effective in CMV retinitis.

    01:50 In terms of peripheral lesions, sometimes we'll use systemic therapy in association with the intravitreal treatment.


    About the Lecture

    The lecture Overview – Antiviral Agents and Treatment of CMV Retinitis – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Author of lecture Overview – Antiviral Agents and Treatment of CMV Retinitis – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD


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