Organization of the Immune System

by Peter Delves, PhD

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    So, because there are all these different strategies, the immune response needs to coordinate its strategy. And of course the immune system is not like people. It doesn’t have a brain, it doesn’t think in the way that you and I can think. But you can use this analogy: a group of individuals getting together and discussing what is going to be the best way of dealing with a particular type of pathogen. And essentially, this is what cells of the immune system do. They get together particularly in the secondary lymphoid tissues and they work out what is going to be the best strategy to deal with a particular pathogenic threat that is present. Once that strategy is agreed upon, there are orders given and cells will be sent out from the secondary lymphoid tissues to go to the place where the infection is. And molecules will be released that can also distribute themselves via the lymphatic system and via the blood circulation to go to the location where the pathogen is. So the troops are dispatched from the secondary lymphoid tissues, and they will hopefully be successful in defeating the enemy. So how does this coordinated response actually work in practice? You may be wondering, well that’s all very well, but how does it really work? Well, there needs to be communication very clearly and we can break down communication in the immune response into two fundamentally different ways of interacting. Different cells of the immune response interacting with each other. One is where molecules on the surface of one cell recognize molecules on the surface of another cell, and following this mutual recognition, signals are sent into either one of the cells or very often into both cells causing cell activation. So this is a cell-cell contact...

    About the Lecture

    The lecture Organization of the Immune System by Peter Delves, PhD is from the course Immune System: Overview and Cells.

    Included Quiz Questions

    1. Cell-cell contact
    2. Activation of the response by regulatory cells
    3. The absence of receptors
    4. Secreted molecules which bind to receptors in the nucleus
    5. More than one type of pathogen to be present
    1. The presence of a pathogen
    2. Cell-cell contact
    3. Secretion of molecules from an immune cell that recruit other immune cells
    4. Receptors of immune cells detecting the presence of immune cascade
    5. Cell damage or death
    1. Elimination of the pathogen
    2. Immune cells binding to DAMPs
    3. Regulatory cells that suppress immune response
    4. Immune cells binding to PAMPs and downregulating the innate immune response
    5. Release of IL-10 and transforming growth factor beta

    Author of lecture Organization of the Immune System

     Peter Delves, PhD

    Peter Delves, PhD

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