Opioid Analgesics – Drugs of Abuse

by Pravin Shukle, MD

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    00:01 Opioid analgesics are another type of drug that are often abused.

    00:05 This includes drugs like heroin, morphine, oxycodone and coedine, meperidine, fentanyl.

    00:14 Now, the antidote to all of these drugs is naloxone and you'll often find this drug in your code kits.

    00:20 And in terms of treating patients with opioid dependance, we use methadone.

    00:22 Opioid analgesics work through the mu, kappa, and lambda receptors.

    00:32 We're going to cover this again in the central nervous system pharmacology section of this course.

    00:37 But just remember that mu, kappa and lambda are all three affected by opioid analgesics.

    00:43 They also may disinhibit the dopaminergic pathways in the CNS. Opioid gives an initial "rush" followed by sedation and coma.

    00:55 One of the most toxic drugs out there on the market right now is fentanyl.

    01:00 And it has become a real epidemic in terms of opioid dependance and opioid abuse.

    01:06 It is 100 times more potent than morphine and it is often sold in patches.

    01:10 Pharmacy thefts are becoming very common place. In my own office for example, we had a break in at the pharmacy next door, and they stole only the fentanyl patches.

    01:21 In 2013, we saw the first upswing of fentanyl thefts and abuse in Chicago, New York, Detroit and Philadelphia.

    01:29 By 2015, it had spread to Canada as well. And by 2016, it is a global problem.

    01:36 We often see now traces of fentanyl in synthetic drugs like MDMA and cocaine, heroin and ecstasy.

    01:45 One of the things that patients might come in and tell you that they're on "Magic" or "The Bomb", this is heroin cut with fentanyl. And "Juicy Go" or "Juicy Blow" is cocaine cut with fentanyl.

    01:56 This is something that has just happened in 2016, big increase in the last three months of 2016 where fentanyl has become a real problem and a real cutting problem with other drugs.

    About the Lecture

    The lecture Opioid Analgesics – Drugs of Abuse by Pravin Shukle, MD is from the course Toxicology. It contains the following chapters:

    • Toxicology: Opipoid Analgesics
    • Fentanyl

    Included Quiz Questions

    1. Naloxone
    2. Methadone
    3. Fomepizole
    4. Flumazenil
    5. N-acetylcysteine

    Author of lecture Opioid Analgesics – Drugs of Abuse

     Pravin Shukle, MD

    Pravin Shukle, MD

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