00:00 Under normocytic classification, normocytic, acute blood loss. 00:05 Decreased RBC production. 00:07 No reticulocytosis. 00:08 Where am I? Good. 00:11 This is normocytic non-hemolytic anemia. 00:13 "But Dr. Raj, will acute blood loss be destruction of RBC?" Sure, but where? On the floor. 00:20 So if you lost your blood, the floor doesn’t count as being intra or extravascular hemolysis. 00:26 When you literally have lost the blood from your body, it’s still going to be non-hemolytic. 00:31 Is that clear? So because you destroyed the RBC once they hit the floor, that doesn’t count. 00:36 You don’t call it hemolysis. 00:39 So our topic here is normocytic non-hemolytic anemia. 00:42 Acute, acute, acute blood loss is a point here. 00:46 In addition, RBC production decreased. 00:49 So what’s your reticulocytosis? Decreased. 00:51 What’s your magic number? Corrected reticulocyte count less than 3%. 00:55 Aplastic anemia. 00:57 Anemia of renal disease. 00:58 What does this mean? No EPO. 01:00 Myelophthisic. 01:01 What does that mean? Well, we’re going to come into a lot of pathologies that use the word myelo, myelo, myelo, right? You’ve heard of myelodysplastic syndrome. 01:09 You’ve heard of myelofibrosis. 01:10 This is myelophthisic. 01:11 We’ll take a look at myeloproliferative. 01:13 And each one of those become important. 01:15 Let’s begin just bit by bit by bit. 01:18 Myelophthisic anemia means that the bone marrow has been absolutely compromised. 01:25 There is space occupying lesion in the bone marrow. 01:27 Remember that patient that I gave you breast cancer? It might metastasize in the bone marrow resulting in bone marrow shutdown. 01:35 What kind of anemia please? Normocytic non-hemolytic low reticulocyte production index. 01:41 If it’s increased RBC loss, it’s the opposite. 01:45 These are hemolytic anemias. 01:46 And then, what is the magic question you ask yourself? Is the RBC being destroyed within the vasculature? What’s your major, major symptom there? Good. 01:55 Hemoglobinuria. 01:56 If it’s extravascular, what's your major significant sign there? And that will be your jaundice or even cholelithiasis, pigment stones.
The lecture Normocytic Anemia: Classification by Carlo Raj, MD is from the course Normocytic Anemia – Red Blood Cell Pathology (RBC).
Which of the following findings is associated with extravascular hemolysis?
Which of the following conditions is associated with an increased number of reticulocytes?
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