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Normocytic Anemia: Classification

by Carlo Raj, MD
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    00:00 Under normocytic classification, normocytic, acute blood loss.

    00:05 Decreased RBC production.

    00:07 No reticulocytosis.

    00:08 Where am I? Good.

    00:11 This is normocytic non-hemolytic anemia.

    00:13 "But Dr. Raj, will acute blood loss be destruction of RBC?" Sure, but where? On the floor.

    00:20 So if you lost your blood, the floor doesn’t count as being intra or extravascular hemolysis.

    00:26 When you literally have lost the blood from your body, it’s still going to be non-hemolytic.

    00:31 Is that clear? So because you destroyed the RBC once they hit the floor, that doesn’t count.

    00:36 You don’t call it hemolysis.

    00:39 So our topic here is normocytic non-hemolytic anemia.

    00:42 Acute, acute, acute blood loss is a point here.

    00:46 In addition, RBC production decreased.

    00:49 So what’s your reticulocytosis? Decreased.

    00:51 What’s your magic number? Corrected reticulocyte count less than 3%.

    00:55 Aplastic anemia.

    00:57 Anemia of renal disease.

    00:58 What does this mean? No EPO.

    01:00 Myelophthisic.

    01:01 What does that mean? Well, we’re going to come into a lot of pathologies that use the word myelo, myelo, myelo, right? You’ve heard of myelodysplastic syndrome.

    01:09 You’ve heard of myelofibrosis.

    01:10 This is myelophthisic.

    01:11 We’ll take a look at myeloproliferative.

    01:13 And each one of those become important.

    01:15 Let’s begin just bit by bit by bit.

    01:18 Myelophthisic anemia means that the bone marrow has been absolutely compromised.

    01:25 There is space occupying lesion in the bone marrow.

    01:27 Remember that patient that I gave you breast cancer? It might metastasize in the bone marrow resulting in bone marrow shutdown.

    01:35 What kind of anemia please? Normocytic non-hemolytic low reticulocyte production index.

    01:41 If it’s increased RBC loss, it’s the opposite.

    01:45 These are hemolytic anemias.

    01:46 And then, what is the magic question you ask yourself? Is the RBC being destroyed within the vasculature? What’s your major, major symptom there? Good.

    01:55 Hemoglobinuria.

    01:56 If it’s extravascular, what's your major significant sign there? And that will be your jaundice or even cholelithiasis, pigment stones.


    About the Lecture

    The lecture Normocytic Anemia: Classification by Carlo Raj, MD is from the course Normocytic Anemia – Red Blood Cell Pathology (RBC).


    Included Quiz Questions

    1. Pigment gallstones
    2. Erythrocytosis
    3. Pancytopenia
    4. Hemoglobinuria
    5. Cholesterol gallstones
    1. Hemolytic anemia
    2. Aplastic anemia
    3. Myelophthisic anemia
    4. Early phase of anemia of chronic disease
    5. Acute blood loss

    Author of lecture Normocytic Anemia: Classification

     Carlo Raj, MD

    Carlo Raj, MD


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