Leukemia, Lymphoma & Myeloma

by Peter Delves, PhD

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    Let us look at tumors of the immune system. Leukemia develops in the bone marrow. There are a number of different types of leukemia. The main ones are acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia and chronic myeloid leukemia. There are subtypes of each of these types of leukemia. Lymphomas in contrast develop in the lymphatic system. Two main lymphomas are Hodgkin lymphoma and Non-Hodgkin lymphoma. Myelomas are tumors of plasma cells. Here we have a stem cell that is giving rise to pre-B lymphocytes. Acute lymphoblastic leukemia is usually derived from immature pre-B cells. Blasts are present in the bone marrow and blood. In chronic lymphocytic leukemia and lymphoma, the malignant population is mature B-cells. In CLL, malignant cells are present in the blood. In lymphoma, the malignant cells are present in the lymph node and sometimes in other tissues. Plasma cells give rise to myeloma. In myeloma, the clone of malignant plasma cells produces a monoclonal immunoglobulin; in other words, all the antibody is absolutely identical because it’s derived from a malignant clone of plasma cell. T-cell malignancies are somewhat less common. T-cells are not infected by Epstein-Barr virus, which is a major way in which B-cells can become malignant. Also T-cells are somewhat more susceptible to apoptosis, and therefore less able to survive. There are also myeloid leukemias derived from myeloid progenitors as well as these lymphoid leukemias that you can see on this slide. Chronic lymphocytic leukemia is rather unusual, in that the leukemic cells have on their cell surface, a molecule that is normally present on B-cells, but also a molecule that is normally present on T-cells. As you can see in this flow cytometry diagram, there are normally CD19+ B-cells, and then separately CD5+ B-cells. However, in chronic lymphocytic leukemia, the cells...

    About the Lecture

    The lecture Leukemia, Lymphoma & Myeloma by Peter Delves, PhD is from the course Tumor Immunology. It contains the following chapters:

    • Tumors of the Immune System
    • Chronic Lymphocytic Leukemia
    • Post-Transplant Lymphoma
    • Multiple Myeloma

    Included Quiz Questions

    1. EBV
    2. HPV
    3. HCV
    4. HIV
    5. CMV
    1. Lymphoma- myeloid progenitors
    2. Leukemia- myeloid progenitors
    3. Leukemia- lymphoid progenitors
    4. Myeloma- plasma cell progenitors
    5. Lymphoma- lymphoid progenitors
    1. CLL
    2. ALL
    3. T cell malignancy
    4. Myeloma
    5. Lymphoma
    1. Malignant plasma cells produce monoclonal antibody of a single specificity
    2. Leukemic cells express molecules normally present on B and T cells
    3. Malignant myeloid progenitors produce rapidly proliferating hematopoietic cells
    4. An overproduction of immature B cells that can be detected in serum
    5. Malignant thymic T cells that express tumor enhancing cytokines

    Author of lecture Leukemia, Lymphoma & Myeloma

     Peter Delves, PhD

    Peter Delves, PhD

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