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HIV Disease: Clinical Course, Treatment & Prophylaxis – Secondary Immunodeficiency Diseases

by Peter Delves, PhD
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    Let’s look at the clinical course of HIV disease. If you look at the yellow line first of all, this is the amount of viremia, measured by the amount of HIV RNA that’s present. As you can see, following the initial infection, the amount of virus RNA rapidly increases. If you look at the blue line, which is the number of CD4 T-cells present, you can see that they decline. At this point, following primary infection, there is the acute HIV syndrome with wide dissemination of virus, and a seeding of lymphoid organs with the virus. However, within a small number of weeks, it seems like things are going well. The number of CD4 T-cells begins to increase, and the amount of virus decreases. However the virus is not being eliminated, it is entering a period of clinical latency. Then after a very variable period of time, which may be a short number of years or maybe many, many years later. The individual will begin to develop constitutional symptoms, there will be opportunistic infections, and opportunistic tumors that begin to arise. And the amount of virus begins to increase. And the number of CD4+ T-cells begins a rapid decline. The patient then has the Acquired Immune Deficiency Syndrome, and without medical intervention, death would be more or less inevitable in the vast majority of individuals. Fortunately, the use of antiretroviral drugs can prevent this process leading to death. Here we see the amount of antibody and cytotoxic T-cells being produced, and the virus particles in the plasma. So again, looking initially at the yellow line, you can see that the virus goes up following an initial infection and then radically goes down, looking at virus particles in the plasma. You’ll see that it looks like a good immune response is...

    About the Lecture

    The lecture HIV Disease: Clinical Course, Treatment & Prophylaxis – Secondary Immunodeficiency Diseases by Peter Delves, PhD is from the course Immunodeficiency and Immune Deficiency Diseases. It contains the following chapters:

    • Clinical Course of HIV Disease
    • Treatment and Prophylaxis

    Included Quiz Questions

    1. 3 days
    2. 24 hours
    3. 7 days
    4. 14 days
    5. 28 days
    1. Anti-envelope antibodies, anti-p24 antibodies
    2. Anti-envelope antibodies, HIV specific CTLs
    3. CD8+ T cells, HIV specific CTLs
    4. CD8+ T cells, anti-p24 antibodies
    5. CD4+ T cells, and anti-envelope antibodies
    1. ...macrophages and memory T cells.
    2. ...secondary lymphoid tissues.
    3. ...the central nervous system.
    4. ...primary lymphoid tissues.
    5. ...tissues local to area of infection.
    1. Melanoma
    2. Lymphoma
    3. Karposi's Sarcoma
    4. Cervical Carcinoma
    5. EBV associated B cell lymphoma

    Author of lecture HIV Disease: Clinical Course, Treatment & Prophylaxis – Secondary Immunodeficiency Diseases

     Peter Delves, PhD

    Peter Delves, PhD


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