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Questions – Diabetes Medications

by Pravin Shukle, MD
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    Okay, let's summarize our drugs in diabetes. First line agent, metformin. It increases insulin sensitivity, low risk of hypoglycemia. TZDs and secretagogues are falling out of favor. The other drugs have essentially disppeared from therapeutic landscape, like the alpha glucosidase inhibitors because of severe side effects. DPP4's are safe and are often combined with metformin. Very very commonly used. SGLT2's are exciting new drugs that may have evidence of heart failure reduction. They should not be used in patients who are volume depleted. There is a study that will be coming out soon talking about the beneficial effects of SGLT2 in heart failure patients. And I'm expecting that it's going to be positive meaning that we may actually see a reduction in mortality morbidity in the future with SGLT2's. So keep your eye on this class very closely because I think they are going to be a blockbuster set of drugs, and I think that they are going to save lives as well. Finally, insulin is the mainstay of type I diabetes, diabetic ketoacidosis, and that acute patient who is coming into the ER with high sugar levels and may not have been diagnosed before. Let's move on to some questions. Insulin inquiry. The effects of insulin include the following. It increases membrane transport of glucose into the hepatocyte using GLUT 2. B, it increases membrane transport of glucose into the myocyte using GLUT 2. It increases membrane transport of glucose into the adipocyte using GLUT 2. And finally D, it decreases membrane transport of glucose into the adipocyte using GLUT 4. What's the correct answer? Good, it increases membrane transport of glucose into the hepatocyte using GLUT 2. Remember that GLUT 2 is in the liver, GLUT 4 is everywhere else. I put this there because believe it or...

    About the Lecture

    The lecture Questions – Diabetes Medications by Pravin Shukle, MD is from the course Endocrine Pharmacology. It contains the following chapters:

    • Drugs in Diabetes: Summary
    • Question 1: Drugs in Diabetes
    • Question 2: Drugs in Diabetes
    • Case Study 1: Drugs in Diabetes
    • Question 3: Drugs in Diabetes
    • Case Study 2: Drugs in Diabetes

    Author of lecture Questions – Diabetes Medications

     Pravin Shukle, MD

    Pravin Shukle, MD


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    The explanation was very clear
    By Emily A. on 04. December 2016 for Questions – Diabetes Medications

    The explanation was very clear. This lecture helped me to better understand this area of pharm! Thank you!