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Blood/Lymphatic Circulation and High Endothelial Venules – Lymphocyte Recirculation and Homing

by Peter Delves, PhD
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    Let’s look at the blood and lymphatic circulation. So here we can see the blood circulation. And lymphocytes and other blood cells will be traveling around in the blood circulation. And they may go to the liver, they may go to the skin, they may go to the kidney or they might go to the gut. Following their arrival at these locations, they can look for antigen. And they can ultimately leave these locations and go to the local lymph nodes. Whether they’re coming from the liver, the skin or the kidney, they can end up in nearby lymph nodes. Lymphocytes that are activated in the Peyer’s patches in the gut can also travel to the local lymph node and in this case, it is the mesenteric lymph nodes. Ultimately, the lymphocytes can leave those lymph nodes and travel via the lymphatic vessels to other lymph nodes, because the lymph nodes are connected to each other via the lymphatics. So they’ll leave via the efferent lymphatics for those particular nodes and then later on enter via the afferent lymphatics to downstream nodes. The lymphocytes can also directly enter into the lymph nodes. They don’t have to enter via the lymphatic vessels; they can actually go straight there from the blood circulation. And they do this by structures within the lymph nodes called high endothelial venules, HEV. Ultimately, after seeing whether or not their antigen is present in the lymph node, the lymphocytes can leave via the efferent lymphatics, again travel through the lymphatic vessels and ultimately they can rejoin the blood circulation via the thoracic duct. So let’s have a look at these two systems. Really they’re very much like a road system and a rail system; two different systems but interconnected, just like you can drive your car to...

    About the Lecture

    The lecture Blood/Lymphatic Circulation and High Endothelial Venules – Lymphocyte Recirculation and Homing by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • The Blood and Lymphatic Circulation
    • High Endothelial Venules

    Included Quiz Questions

    1. CCR7
    2. CD7
    3. CD21
    4. CCL19
    5. PNAd
    1. Mesenteric lymph nodes
    2. Subcutaneous lymph nodes
    3. Spleen
    4. Renal lymph nodes
    5. Cervical lymph nodes
    1. Bypass the lymphatic circulation and enter lymph nodes directly
    2. Travel out of the efferent lymphatic vessels
    3. Enter Thoracic duct directly
    4. Drain lymph nodes into bloodstream
    5. Recognize antigens in lymph nodes
    1. T cell- L selectin, HEV- PNAd
    2. T cell- L selectin, HEV- CCL19
    3. T cell- L selectin, HEV- CD4
    4. T cell- CCR7, HEV- PNAd
    5. T cell- CD21, HEV- PNAd

    Author of lecture Blood/Lymphatic Circulation and High Endothelial Venules – Lymphocyte Recirculation and Homing

     Peter Delves, PhD

    Peter Delves, PhD


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