Overview – Bacterial Protein Synthesis Inhibitors (Antibiotics)

by Pravin Shukle, MD

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    Let's move on to another category of antibacterial agents, the Bacterial Protein Synthesis Inhibitors. So the bacterial protein synthesis inhibitors are narrow spectrum agents. They act either on the 50 S subunit such as linezolid or streptogramins or lincosamines. Or the broad spectrum agents that are like the macrolides. and chloramphenicol. Other broad spectrum agents that act on the 30 S subunit include the tetracyclines, the aminoglycosides. Now let's just quickly do some definitions. Because we need to do this before we go on. There's something called as post-antibiotic effect. So this is an anti-ineffective effect that lasts after the elimination of the antibiotic from the body. That's often because we have some kind of, I wouldn't say permanent but long lasting effect in this case on the 50 or 30 S subunits. Bactericidal means that it kills bacteria. Bacteriostatic means that it just stops the bacteria from replicating but doesn't kill them. So the bacteria are still alive but the numbers aren't increasing. So the other immune mediated, killing of the bacteria can occur unimpeded. The 70 S ribosomal mRNA subunit is composed of a 50 S and a 30 S. Okay, I know 50 plus 30 is 80. And how come 50 plus 30 equal 70. Don't worry about it, the point is that the 50 S and the 30 S make up 70 S unit. Time dependent agents. So these are drugs that have increased killing activity with time. This is different from the concentration dependent killing where the drugs have increased killing activity with concentration. So there you have some basic definitions and we're going to be using them as we go forward in this lecture. Let's go on to the 70 S ribosomal unit. The 70 S ribosomal unit is made up of 50 S...

    About the Lecture

    The lecture Overview – Bacterial Protein Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. They must act on the 50S subunit of the ribosome.
    2. They are always bactericidal.
    3. They include antibiotics such as tetracyclines and aminoglycosides.
    4. They involve a narrow therapeutic index.
    5. They are effective against a wide range of disease causing bacteria.
    1. Tetracyclines
    2. Chloramphenicol
    3. Linezolid
    4. Streptogramins
    5. Macrolides
    1. An agent that inhibits bacteria from replicating without necessarily killing them.
    2. An agent that kills bacteria upon exposure.
    3. An agent with increased killing activity with increased concentration.
    4. An agent whose activity is enhanced with increased duration of exposure.
    5. An agent whose effect lasts after the elimination of antibiotics from the body.

    Author of lecture Overview – Bacterial Protein Synthesis Inhibitors (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD

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