Antituberculosis Drugs – Antimycobacterial Agents

by Pravin Shukle, MD

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    About the Lecture

    The lecture Antituberculosis Drugs – Antimycobacterial Agents by Pravin Shukle, MD is from the course Antimicrobial Pharmacology. It contains the following chapters:

    • Tubercolosis Agents - First Line Drugs
    • Tubercolosis Agents - Second Line Drugs

    Included Quiz Questions

    1. Start pyridoxine and continue isoniazid.
    2. Discontinue isoniazid immediately, but maintain the other drugs in the regimen.
    3. Observe the patient only, as it is usually a self-limiting side effect.
    4. Switch to the 2nd line regimen of antituberculosis drugs.
    5. Start probenecid and decrease dose of isoniazid.
    1. Rifampin
    2. Isoniazid
    3. Streptomycin
    4. Pyrazinamide
    5. Ethambutol
    1. Rifabutin has less cytochrome induction activity.
    2. Rifabutin also has activity against the HIV virus.
    3. Rifabutin is metabolized in the liver while rifampin is metabolized in the kidney.
    4. Rifampin has a higher risk for renal failure compared to rifabutin.
    5. The HIV virus produces esterases which break down rifampin but not rifabutin.
    1. Non-gouty polyarthralgia
    2. Gout
    3. Visual disturbances
    4. Orange discoloration of urine and feces
    5. Myalgia
    1. Rifampin
    2. Ethambutol
    3. Clarithromycin
    4. Streptomycin
    5. Isoniazid

    Author of lecture Antituberculosis Drugs – Antimycobacterial Agents

     Pravin Shukle, MD

    Pravin Shukle, MD

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