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Quiz Questions and Case Studies – Antibacterial Agents (Antibiotics)

by Pravin Shukle, MD
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    Let's ask some question about our aminogylcosides. The following is true about aminoglycosides. A) Aminoglycosides bind to the 30 S subunit of the bacterial ribosome. B) Aminoglycosides have no cell wall activity. C) Gentamicin and tobramicin are associate with vestibular ototoxicity. Amikacin and kanamycin are associated with auditory ototoxicity. and D) All of the above is true. And the right answer is all of the above is true. Let's do another question a girl with a red rash. A 12 year old woman has severe staphylococcal skin infection after a motor vehicle accident. She is intubated and ventilated in the intensive care unit. She was started on an intravenous vancomycin drip. She develops a body wide rash without wheals. Her core temperature has climbed to 37.9 degrees Celsius. Her blood pressure is 112/77. Her heart rate is a 109 beats per minute. Her white count is 23. What is happening to this patient? A) She has a leukemic rash; the patient has had a progression of her undiagnosed leukemia with a leukemic rash. B) Severe renal failure due to acute tubular necrosis, with a uremic rash. C) Septic shock; the septic meningitis is now a global sepsis with severe peripheral vasodilation. Or D) She has developed a cutaneous reaction due to the vancomycin. Which is the right answer? Good, she has developed a cutaneous reaction. So although a leukemic rash is a possibility. She does not fit the clinical picture. And it seems kind of an unlikely diagnosis. Acute tubular necrosis is not a common reaction to vancomycin. Sepsis is certainly an important consideration and your major differential diagnosis here. But her heart rate is within acceptable limits for a child in intensive care unit. And the blood pressure is actually pretty normal. She would have a much lower blood...

    About the Lecture

    The lecture Quiz Questions and Case Studies – Antibacterial Agents (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Author of lecture Quiz Questions and Case Studies – Antibacterial Agents (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD


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