Lectures

Allergy: Diagnosis, Therapy and Treatment of Asthma – Hypersensitivity

by Peter Delves, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides Hypersensitivity.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    Atopic allergy can be diagnosed using the skin prick test, where small amounts of the suspected allergen are injected under the skin. This leads to the release of inflammatory mediators from any mast cells that have been pre-sensitized with IgE antibody against the suspected allergen. This will lead to vasodilation and edema causing the characteristic wheal and flare response that is detected as a response to the suspected allergen, if that proves to be the allergen that is responsible for the patient’s symptoms. The amount of IgE specific for a particular allergen that is present in a patient can be measured using the allergen specific IgE test or RAST. In this test, the allergen is immobilized on a disc or some other surface, and then patient’s serum is added. If the patient has antibodies that are specific for the allergen, then those antibodies will bind to the allergen. If the antibody is IgE antibody, it can be detected using a labeled anti-IgE antibody. In the past, the label most commonly employed was a radioactive isotope. Hence, the name of this test, RAST which stands for radioallergosorbent test. However nowadays, most commonly instead of using a radiolabel, some other type of detectable label is used. For example, an enzyme that causes a colour change in a substrate. What are the therapeutic options for allergy? Well of course the easiest approach is to remove or avoid the allergic trigger. If you are allergic to the cat, then it would be a good idea maybe to give your cat away to a friend. If you’re allergic to pollen, don’t go out in the spring time. Of course this is very easy to say, it’s much harder to achieve in practice. But where possible, avoidance of the allergen is the best. And if you’re...

    About the Lecture

    The lecture Allergy: Diagnosis, Therapy and Treatment of Asthma – Hypersensitivity by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease. It contains the following chapters:

    • Diagnosis of Atopic Allergy
    • Therapeutic Options for Allergy
    • Treatment of Asthma
    • Allergy Immunotherapy

    Included Quiz Questions

    1. β-adrenergic agonist
    2. H₁ receptor antagonist
    3. Anti-IgE antibody
    4. Leukotriene antagonist
    5. Corticosteroid
    1. Mast cells that have been sensitized to the allergen in the past
    2. Circulating IgE antibodies
    3. IL-33 release from Dendritic cells
    4. Anti-IgE labelled antibodies
    5. Enzymatic reaction to injected allergen
    1. Mast cell Degranulators
    2. H1 Blockers
    3. Corticosteroids
    4. Leukotriene inhibitors
    5. Immunotherapy
    1. Immune reaction is shifted away from a Th2/IgE mediated reaction, Treg cells are increased
    2. Mast cells are stabilized and the cytokines that mediate the immune response are downregulated
    3. Smooth muscles in allergy-prone areas of the body are directly sensitized
    4. Block the production of Histamine, decreases severity of immune reaction
    5. Directly block activity of IgE on Mast cells

    Author of lecture Allergy: Diagnosis, Therapy and Treatment of Asthma – Hypersensitivity

     Peter Delves, PhD

    Peter Delves, PhD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0