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Adrenal Hormone Synthesis

by Thad Wilson, PhD
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    So now what is the synthesis pathways of these various hormones. Let's start with adrenal cortex hormones and then move into adrenal medulla hormones. So in terms of the cortex, if we sliced the adrenal gland right in half, if you look through the various layers of the adrenal gland, we start with the capsule. The capsule is a fibrous layer and it's mainly connected tissue. Where we become most important with our hormone synthesis part is in the top most layer. The zona glomerulosa. Here is where aldosterone is synthesised. Aldosterone is known as mineralcorticoid. In this case mineralcorticoid is because it is involved with sodium retention which is one of our minerals. Below this level, we have the zona fasciculata is involved with cortisol production. This is known as a glucocorticoid. You maybe wondering yourself, what is this corticoid portion. That is to tell you that is part of a steroid hormone base. In this case it was initially named glucocorticoid because it's involved with glucose metabolism. Cortisol though is often known as a stress hormone. It's released in times of stress and will go through all the different functions that it has. We also have a zona reticularis. This is where the androgens are produced. Where the androgens are these will be things like DHEA and androstenedione. These will be involved with secondary sex characteristics. Finally if we go to our lower most level, this is now no longer in the cortex is the adrenal medulla. And remember the adrenal medulla was where epineprhine is released. Now we talk through the synthesis pathways for adrenal steroid hormones. The biggest picture that you need to remember is you start off with cholesterol. Cholesterol is the backbone of all these three hormones. What's starts the process down the stairs,...

    About the Lecture

    The lecture Adrenal Hormone Synthesis by Thad Wilson, PhD is from the course Endocrine Physiology.


    Included Quiz Questions

    1. VMAT1
    2. Tyrosine hydroxylase
    3. Chromoganin
    4. Aldosterone synthase

    Author of lecture Adrenal Hormone Synthesis

     Thad Wilson, PhD

    Thad Wilson, PhD


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    Informative lecture
    By Andrew T. on 06. December 2016 for Adrenal Hormone Synthesis

    Informative lecture, was going a little bit too fast but repeating the video helped.