El número necesario a tratar (NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat) es el número de pacientes que se necesitan tratar para prevenir 1 resultado secundario adicional (e.g., accidente cerebrovascular, muerte). Por ejemplo, si un medicamento tiene un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat de 10, significa que 10 personas deben recibir tratamiento con el medicamento para prevenir 1 resultado secundario adicional. El NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat es el inverso de la reducción del riesgo absoluto (RRA), que es igual a la tasa de resultados secundarios que ocurren enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo de control menos la cantidad de resultados secundarios enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo experimental.
El número necesario a tratar (NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat); y su análogo, el número necesario para dañar (NND), son simplemente otras medidas del tamaño del efecto, como la d de Cohen, y ayudan a relacionar una diferencia enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el tamaño del efecto con la relevancia clínica del mundo real.
Número necesario a tratar
El NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat significa cuántos pacientes necesitarían ser tratados para mejorar el estado de 1 paciente adicional, que de otro modo no habría mejorado sin ese tratamiento enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum particular.
El inverso de la reducción de riesgo absoluto (RRA) = 1/RRA
El NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat es un número entre 1 e infinito:
Un número más bajo indica un tratamiento más efectivo.
Las fracciones se redondean alALAmyloidosis siguiente número entero.
Un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat perfecto sería 1, lo que significa que por cada paciente tratado, 1 mejoró enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el ensayo, que no habría mejorado sin ese tratamiento específico.
Reducción de riesgo absoluto, diferencia de riesgo absoluto (DRA) y exceso de riesgo absoluto (ERA)
Todos estos términos representan el valor absoluto de la diferencia entre la proporción (expresada como porcentaje, fracción o incidencia) de pacientes enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo control (Pc) que tuvieron el resultado de interés y la proporción de pacientes enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo experimental (Pe) con eso el resultado de interés:
Debe interpretarse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum contexto: una estimación puntual de NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat aislada tiene poco valor, aunque aproximadamente el 50% de losLOSNeisseria estudios clínicos no proporcionan la información contextual necesaria.
El NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat utiliza la RRA y no la reducción de riesgo relativo (RRRRRRMeasures of Risk), que tiende a enfatizar demasiado el beneficio.
Por ejemplo, si el riesgo inicial fuera del 0,2% y el medicamento X redujera este riesgo alALAmyloidosis 0,1%, la RRRRRRMeasures of Risk seguiría siendo del 50%, pero la RRA sería solo del 0,1%, lo que no es una gran diferencia con respecto a la línea de base.
Como la RRRRRRMeasures of Risk está directamente correlacionada con la RRA, el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat también está inversamente correlacionado con la RRRRRRMeasures of Risk.
El NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat le dice cuántos pacientes se beneficiarían, pero no cuánto se pueden beneficiar. Las respuestas a las siguientes preguntas deben proporcionarse con el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat para poder interpretarlo completamente:
¿Cuál es el riesgo inicial de losLOSNeisseria pacientes enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el estudio?
¿Cuál es el comparador? (e.g., ¿ningún tratamiento?, ¿placeboPlaceboAny dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.Epidemiological Studies?, ¿otra terapia?)
¿Cuál es el resultado? (e.g., ¿curación completa?, ¿mejora del 30%?)
¿Cuánto dura el estudio? (debe incluirse con el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat)
¿Qué es el intervalo de confianza?
Interpretación
Cuanto menor sea el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat, mejor; cuanto mayor sea el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat, menos personas recibirán ayuda.
Las intervenciones de tratamiento que tienen un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat de uno o dos dígitos bajos generalmente se consideran efectivas para tratar afecciones sintomáticas.
Para losLOSNeisseria resultados con una importancia clínica alta, como la prevención de la muerte, también se puede considerar útil un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to TreatenENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria 100 inferiores.
Para las terapias preventivas, losLOSNeisseriaNNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat también pueden ser altos.
Número Necesario Para Dañar
El NND es el número adicional de personas que necesitan estar expuestas alALAmyloidosis riesgo (exposición dañina o tratamiento) para que 1 persona adicional desarrolle la enfermedad enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum comparación con el grupo no expuesto.
El NNHNNHThe NNH is the additional number of individuals who need to be exposed to risk (harmful exposure or treatment) to have 1 extra person develop the disease compared to that in the unexposed group.Number Needed to Treat es el inverso del ERA (1/ERA).
La relación entre NND y NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat: Un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat negativo indica que el tratamiento tiene un efecto nocivo. Por ejemplo, un NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat de −10 indica que si 10 pacientes son tratados con el nuevo tratamiento, una persona adicional se vería perjudicada enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum comparación con losLOSNeisseria pacientes que reciben el tratamiento estándar, i.e., el NND = 10.
AlALAmyloidosis igual que el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat, el NND debe interpretarse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum contexto.
Cálculo del NNT y NND
La base para calcular el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat y NND
Una tabla de contingencia de 2 x 2 usa un resultado binario y 2 grupos de sujetos para mostrar la base para calcular NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat y NND. Cada resultado debe expresarse como una proporción, porcentaje o incidencia, y no como el número real de sujetos.
Resultado
Grupo tratado
Grupo control
Positivo
a
b
Negativo
c
d
Total
a + c
b + d
Esta tabla de contingencia de 2 x 2 usa un resultado binario y 2 grupos de sujetos para mostrar la base para calcular el NNT y NND. Cada resultado debe expresarse como una proporción, porcentaje o incidencia, y no como el número real de sujetos. NNT: número necesario a tratar NND: número necesario para dañar
Si lo siguiente es cierto, la diferencia de proporciones es P tratado – P control.
P tratado = la proporción de sujetos con un resultado positivo enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo tratado
P tratado = a/(a + b)
P control = la proporción de sujetos con un resultado positivo enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el grupo control
P control = b/(b + d)
La diferencia de riesgo absoluto (DRA) es igual a la RRA, que se calcula como el valor absoluto de la diferencia entre P tratado y P control.
Entonces, el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat se puede calcular como:
Si el grupo tratado o expuesto tiene un peor resultado que el control, la RRA se llama ERA. EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum ese caso, el NNTNNTThe number needed to treat (NNT) is the number of patients that are needed to treat to prevent 1 additional adverse outcome (e.g., stroke, death). For example, if a drug has an nnt of 10, it means 10 people must be treated with the drug to prevent 1 additional adverse outcome.Number Needed to Treat se llama número necesario para dañar (NND). EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum ambos casos, el cálculo es el mismo (NND = 1/DRA).
Preguntas de Práctica
Un ensayo clínico aleatorizado estudió el efecto de la exposición infantil alALAmyloidosis humo de 2da mano sobre la incidencia de adenocarcinoma broncogénico. El estudio incluyó a 100 sujetos (50 expuestos alALAmyloidosis humo de 2da mano enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia y 50 controles sanos sin exposición enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia) e involucró el seguimiento de la incidencia de adenocarcinoma broncogénico a lo largo de la vida. LosLOSNeisseria datos del estudio se muestran enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la siguiente tabla:
Resultado
Grupo Expuesto
Grupo Control
Adenocarcinoma broncogénico presente
18
7
Adenocarcinoma broncogénico no presente
32
43
Total
50
50
Pregunta 1
¿Qué es el NND?
Respuesta: NND = 1/diferencia de riesgo absoluta (llamada “ERA” cuando se trata de NND). ERA = Pe – Pc = 18/50 – 7/50 = 0,22. NND = 1/0,22 = 4,45 ⇾ 5, lo que significa que 5 personas deben estar expuestas alALAmyloidosis humo de 2da mano enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia para que 1 persona adicional desarrolle adenocarcinoma broncogénico enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum comparación con el grupo no expuesto.
Pregunta 2
¿Cuál es el aumento de riesgo relativo enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el estudio citado enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la Pregunta 1?
Respuesta: El aumento del riesgo relativo = (Pe – Pc)/Pc = (18/50 – 7/50)/7/50 = 1,57, lo que significa que las personas expuestas alALAmyloidosis humo de 2da mano enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia tienen 1,57 veces más probabilidades de desarrollar adenocarcinoma broncogénico después de la exposición alALAmyloidosis humo de 2da mano que losLOSNeisseria que no estuvieron expuestos.
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