00:01 In this lecture, we'll discuss allergic reactions including anaphylaxis, urticaria, angioedema and food allergy. 00:09 So there are generally 4 types of hypersensitivity reactions. 00:14 This is your basic science material. 00:16 Type 1 is IgE mediated and an example would be anaphylaxis. 00:21 Type 2 is IgG or IgM mediated antigen on a target cell and an example of that would be rheumatic heart disease. 00:30 Type 3 is when there are circulating antigen/antibody complexes. 00:35 An example of this type of reaction is for example serum sickness. 00:39 And a type 4 hypersensitive reaction is generally a T-cell mediated response such as poison ivy, or a PPD test, or milk protein allergy presenting as blood in the stool as an infant. 00:53 So, let's start with type 1 hypersensitivity reactions. 00:59 In general, these require exposure to a protein that's large enough to be an antigen. 01:05 So, the patient has an initial exposure to that antigen, and they produce an antigen-specific IgE. 01:12 That IgE now binds to a mast cell, and on a subsequent exposure to that antigen, they generally have a generalized mass cell degranulation resulting in a type 1 hypersensitivity reaction. 01:28 There are many things that can trigger such a reaction. 01:31 These include foods, especially food additives, legumes, tree nuts, seafood, eggs, dairy, shellfish, berries. 01:39 These are all very common. 01:41 In fact, among children who have type 1 hypersensitivity reactions to food about 85% of them are to food when we know what the allergen is. 01:53 Still, remember, at least a third of the time we have no idea what triggers the allergy. 01:58 Also, patients can be allergic to medications. 02:01 Probably penicillins and sulfas are the most common, but they could also be allergic to salicylates to certain vaccines or to anaesthetics. 02:10 Also patients can have environmental allergies. 02:14 Bee stings and wasp stings are particularly problematic. 02:18 Patients may be allergic to temperature changes to exercise, to latex. 02:22 Lots of different possibilities. 02:25 So, urticaria is our classic type 1 hypersensitivity reaction. 02:30 We also call it "hives". 02:32 These lesions will be anywhere from 1 mm to 10 cm large. 02:37 They can be huge or small. 02:38 These lesions are profoundly itchy, and they're stimulated by skin contact, which means the more you scratch them, the more they itch. 02:48 What you'll notice about them is that they sort of "come and go" even before your eyes. 02:53 You may walk in, see a patient with hives, and before you're done with your conversation, the one you were looking at on the leg is gone, and there's a new one on the arm. 03:02 They may be associated with angioedema, which is another type of type 1 hypersensitivity reaction. 03:10 What's key is that these are acute and generally short-lived. 03:14 Patients usually only have this reaction for maybe days to maybe a week out, from when they're first encountered that antigen, and had a response to it, which would be the second time they ecountered the antigen. 03:26 Alternatively, occasionally they can become chronic. 03:30 These are when hives last longer than 6 weeks. 03:33 This can really be problematic when it happens. 03:37 So, the diagnosis of urticaria is based on appearance. 03:41 This is a great picture. 03:42 Just remember they're sort of serpiginous, round with central clearing. 03:46 This is a classic hives reaction. 03:48 They're a little bit raised. 03:50 We're going to treat this with oral antihistamines. 03:54 That's our mainstay of therapy, basically diphenhydramine. 03:58 Patients may add H2 antagonists, such as famotidine, to the mix to try and limit the effect of the histamines. 04:06 This has a minimal benefit, but it's certainly isn't particularly harmful to be on famotidine for a few days while you're waiting for your hives to improve. 04:16 What's key is steroids are generally not helpful, so we do not routinely provide steroids to patients with urticaria. 04:23 So, angioedema, I mentioned this earlier. 04:28 This is sort of like hives gone wild. 04:30 This is a general localized swelling that happens in an area, often on the face. 04:37 It can happen around the eyes. 04:38 It can happen on the lips, the mouth, or the tongue. 04:42 It may happen on the genitalia, or the extremeties, or even in the bowel wall causing either bowel discomfort or nausea, vomiting, or more systemic symptoms. 04:54 What's key though and where we would worry, is when this involves the lips, the mouth, and the tongue, because we worry about the patency of the airway. 05:02 Sometimes, the swelling can get so bad, the patient may have trouble breathing. 05:06 This is an allergic reaction -- or it can be inherited. 05:12 There are rare diseases such hereditary angioedema where patients can get this randomly throughout their lives. 05:20 In specific, we sometimes see this to certain medications and the classic one is the ACE inhibitor. 05:27 Any patient on an ACE inhibitor, who gets this reaction, it's an emergency because we may lose that airway. 05:34 Additionally, NSAIDS can do this and calcium channel blockers can rarely do this. 05:40 The classic one is ACE inhibitors. 05:43 So, what do we if we have a patient with angioedema? Well, first, remove the offending agent. 05:49 Get them off the drug that's caused it or whatever has caused it, get them out of it, get it out of them. 05:53 Then we're going to treat it similarly to hives. 05:56 So, we're going to give the benadryl we talked about. 05:59 We'll probably do that around the clock. 06:01 We may add Zantac. 06:03 If the airway is involved, we generally would admit these patients to the hospital to make sure that that airway isn't goint to become compromised. 06:11 If the airway is obstructed, we immediately give epinephrine and provide immediate airway stabilization and airway support. 06:19 It may require intubation and in very rare cases, an actual tracheostomy, if you're incapable of getting an intubation. 06:27 Sometimes a layringoscopic intubation is needed.
The lecture Urticaria (Hives) and Angioedema in Children by Brian Alverson, MD is from the course Pediatric Allergy and Immunology. It contains the following chapters:
What is least likely to result in angioedema?
Which of the following types of hypersensitivity reactions is IgE mediated?
In type I hypersensitivity reactions, IgE binds to which cells causing their degranulation upon re-exposure?
A child is brought to the emergency department with rapid-onset urticarial rash and pruritus after eating peanuts. He has no respiratory distress, wheezing, stridor, or facial edema. Which of the following is the most appropriate treatment at this time?
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Very good lecture. As usual: clear, concise and comprehensive. I put 4 stars, because contrary to lectures about Asthma or Bronchiolitis, I felt that the experience of the teacher did not enrich this lecture as much as it did in the previous above. Otherwise, it is still top-notch learning material.
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