Severe hyp-hypercalcemia, what do you want
Remember, with the severe hypercalcemia, there’s
quite a bit of calcium that’s being filtered
into the urine.
Thus may result in osmotic diuresis and kind
of like what we talked about earlier with
uncontrolled diabetes haemolytis.
What’s one of the first steps that you’re
Replenish, replenish, replenish the fluid.
Mobilization, if possible.
Remember, that mobilization, lightweight to
a certain extent, may then also help with
Bisphosphonates allows for proper mineralization
of the bone to remove the calcium out of the
circulation, inhibit resorption.
Effect begins within two days, maximum at
a week for bisphosphonates.
Calcitonin, technically, at this point, it
may inhibit bone resorption.
That’s all that I wish to say about this,
but in pathology, please make sure that you
keep in mind with calcitonin, parafollicular
C cells and use as a marker with medullary
cancer of the thyroid.
Glucocorticoids, effective in Vitamin D-mediated
So, for example, your patient, African-American
lady, young, maybe in her early 40’s and
she has hypertension and upon chest X-ray,
you find these granulomas.
In addition to that, you find hypercalcemia
and glucocorticoids seem to be quite effective
in those patients who has sarcoidosis.
It inhibits the conversion or inhibits calcitriol
production in general.