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T-Cell Immunodeficiencies: Hyper IgM Syndrome, Wiskott-Aldrich Syndrome and MHC Class II Deficiency – Primary Immunodeficiency
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About the Lecture
The lecture T-Cell Immunodeficiencies: Hyper IgM Syndrome, Wiskott-Aldrich Syndrome and MHC Class II Deficiency – Primary Immunodeficiency by Peter Delves, PhD is from the course Immunodeficiency and Immune Deficiency Diseases. It contains the following chapters:
- Examples of Immunodeficiencies Affecting T-Cells
- Hyper-IgM Syndrome
- Hyper-IgE Syndrome
- DiGeorge Syndrome
- Wiskott-Aldrich Syndrome
- MHC Class I Deficiency
- MHC Class II Deficiency
Included Quiz Questions
Mutations in which one of the following genes is NOT associated with hyper-IgM syndrome?
- TBX1
- CD40L
- NEMO
- UNG
- AID
All of these are examples of autoimmune diseases that result from primary immunodeficiency EXCEPT..?
- Myasthenia gravis
- Autoimmune Polyendocrine Syndrome -1
- Chronic Granulomatous Disease
- Wiskott-Aldrich Syndrome
- DiGeorge syndrome
Mutations in the RAG genes can prevent T-cell development...?
- ...from the Pro-T to Pre-T stage.
- ...from the common lymphoid progenitor to the Pro-T stage.
- ...from the Pre-T to double positive T cell stage.
- ...of CD4⁺ but not CD8⁺ T-cells.
- ...of CD8⁺ but not CD4⁺ cells.
Which immunodeficiency results in failure of the thymus to develop?
- DiGeorge syndrome
- Hyper-IgE syndrome
- MHC Class II Decificiency
- Wiskott-Aldrich syndrome
- Hyper-IgM syndrome
A defect in the Wiskott-Aldrich Protein causes a defect in all of the following EXCEPT...?
- ...selection of CD4+ T cells.
- ...phagocyte chemotaxis.
- ...T-cell motlity.
- ...dendritic cell trafficking.
- ...T-cell cytoskeleton polarization towards B cells.
Author of lecture T-Cell Immunodeficiencies: Hyper IgM Syndrome, Wiskott-Aldrich Syndrome and MHC Class II Deficiency – Primary Immunodeficiency
Peter Delves, PhD
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