Serine Family and Methionine Catabolism

by Kevin Ahern, PhD

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    The next amino acid metabolism family I want to consider is that of the serine family. So, the serine family, as the other families are described, uses serine as a central amino acid for branching out to make the other amino acids. So to understand this family, I need to first describe how serine is synthesized. There were two main pathways that lead to serine in our cells. The first one starts form 3-phophoglycerate. Now, this molecule, if you recall, is found in the glycolysis pathway so we see a linkage between glycolysis and this amino acid metabolism. The reaction starts with an oxidation of the 3-phophoglycerate as we can see here. In this reaction, 3-phosphohydroxypyruvate is produced as a result of that oxidation. The transamination of 3-phosphohydroxypyruvate leads to orthophosphoserine or O-phosphoserine as we can see here. And the removal of phosphate from O-phosphoserine results in the production of the amino acid serine. It's a very simple set of steps that make that. A second way of making serine starts with glycine. And this is a set of reactions that I've described in other lectures here relating to folate metabolism. This is a very important reaction not only for making serine but also in the reverse direction for making glycine, as well as interchanging the formation of different folates as we will see. So, here's the reaction that occurs. We start in this case with glycine and we start with this rather complicated folate name N5, N10-methylene tetrahydrofolate, mouthful. This reaction, a CH2OH group from the methylene tetrahydrofolate is transferred onto glycine to make serine. The product of that transfer is tetrahydrofolate. So remember from folate metabolism that this is a way of interchanging the different folates. The reaction as I said can go on the reverse direction and...

    About the Lecture

    The lecture Serine Family and Methionine Catabolism by Kevin Ahern, PhD is from the course Amino Acid Metabolism. It contains the following chapters:

    • Serine Family
    • Methionine Catabolism

    Included Quiz Questions

    1. 3-phosphoglycerate
    2. DHAP
    3. 2-phosphoglycerate
    4. Pyruvate
    5. PEP
    1. Glycine
    2. Alanine
    3. Cysteine
    4. Arginine
    5. None of the above

    Author of lecture Serine Family and Methionine Catabolism

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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