Pattern Recognition Receptors (PRRs)

by Peter Delves, PhD

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    So how is a threat detected? Well, there are these Pattern Recognition Receptors - PRRs, that can recognize infectious agents. And what they recognize on the infectious pathogen are structures that are called Pathogen-Associated Molecular Patterns or PAMPs, P-A-M-P. Also, Pattern Recognition Receptors, as well as recognizing PAMPs on foreign infectious agents can recognize structures associated with damage to our own body cells. And we call these structures Damage-Associated Molecular Patterns. So Pattern Recognition Receptors can recognize both PAMPs and DAMPs. And these can be present on the cell surface or sometimes inside cells, and these may be on pathogen cells or they may be on our own body cells. What is important to appreciate, is that although this recognition is often described as being broadly specific, what is actually being recognized is recognized in a very, very highly specific way. So for example, we’ll mention a few Pathogen-Associated Molecular Patterns in a few moments. One of them is called lipopolysaccharide or LPS. LPS is found on Gram-negative bacteria. And there are lots of different types of Gram-negative bacteria. So LPS is shared between several different bacteria but the recognition of LPS is very, very highly specific. So recognition is structurally-specific but what is recognized is common to whole groups of organisms or host cells. These Pattern Recognition Receptors can be inside cells, in other words, intracellular. And if they’re intracellular, if they’re inside a cell, they may be present on the endosomes within the cell or they may be present within the cytosol of the cell. Alternatively, they may be present on the surface of cells, cell surface Pattern Recognition Receptors. Or indeed, they may be released or secreted from cells as soluble Pattern Recognition Receptors. You can now look at a number of different Pattern Recognition Receptors and...

    About the Lecture

    The lecture Pattern Recognition Receptors (PRRs) by Peter Delves, PhD is from the course Innate Immune System. It contains the following chapters:

    • Pattern Recognition Receptors
    • Overview of DAMPs and PAMPs

    Included Quiz Questions

    1. HMGB1 and LPS
    2. Peptidoglycan and Advanced Glycation Endproducts
    3. LPS and Peptidoglycan
    4. CpG and uric acid
    5. N-acetylglucosamine and mannose
    1. The ability to recognize very specific structures that is common to large groups of organisms
    2. The ability to recognize host and pathogens
    3. The ability to recognize a variety of pathogens while being able to distinguish them from the host
    4. The ability to recognize a variety of organisms while identifying which ones are threats
    5. The ability to recognize both PAMPs and DAMPs from a variety of cells
    1. ...nucleic.
    2. ...endosomal,
    3. ...cytosolic.
    4. ...as acell surface molecule.
    5. ...as a secreted soluble receptor.
    1. Recognizes viral single stranded RNA
    2. Include the receptor NLRP3
    3. Recognizes the presence of Uric Acid
    4. Recognizes DAMPs from damaged cells
    5. Is a cytosolic PRR

    Author of lecture Pattern Recognition Receptors (PRRs)

     Peter Delves, PhD

    Peter Delves, PhD

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    Very Good!!
    By Shaden A. on 25. April 2017 for Pattern Recognition Receptors (PRRs)

    Gave me a clear informations in simplest way!! Also her accent very God!! i'm from KSA and i found it easily to understand Love it! Thank u.

    Great way to explain and communicate the ideas to the students
    By Martin B. on 06. February 2017 for Pattern Recognition Receptors (PRRs)

    Great way to explain and communicate the ideas to the students.