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Clinical Features of Primary Hyperparathyroidism & Osteitis Fibrosa Cystica

by Carlo Raj, MD
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    Primary hyperparathyroidism, asymptomatic, increased PTH-PTH, which will then drive the removal of calcium from your bone, may result in hypercalcuria. So, you have, here, hypercalcemia and hypercalcuria. There is a condition that I talked to you about earlier where it was your hypercalc-... hypocalcuric hypercalcemia. Thus familial, if you remember correctly. There’s a decrease here in phosphorus because that excess PTH is working on the kidney and the PCT to then flush out the phosphate. Speaking of the PCT, the PTH is then stimulating 1-alpha-hydroxylase resulting in activation of Vitamin D. There might be symptoms of primary hyperparathyroidism which includes your pathologic fractures and so forth that we talked about… brain, depression and that particular bone damage that’s taking place extensively is called osteitis fibrosa cystica a.k.a. Von Recklinghausen’s disease of the bone. Next, what may then happen... remember we called as the brown tumor? Well, remember, this is not an actual tumor that you find in your bone; it’s a fact that you’re going to have replacement of this cavity being caused by excess PTH activity and osteoclasts in which you find haemosiderin within the cavity, you call this “a brown tumor”. Yes, PTH works in the kidney to reabsorb the calcium, but as you know, majority of your calcium is stored in bone. You start breaking down this bone, which PTH will do, all these calcium gets filtered through your glomerulus, may result in polyuria in males and result in calcium stones. Symptoms of hypercalcemia, what are they again? In the brain, it will be depression and perhaps seizures; if it’s intestine and such, then you’re thinking about your peptic ulcer disease of the duodenal type maybe pancreatitis or gall stones; there might be constipation, pancreatitis, altered mental status and peptic ulcers. Now what osteitis fibrosa cystica is...

    About the Lecture

    The lecture Clinical Features of Primary Hyperparathyroidism & Osteitis Fibrosa Cystica by Carlo Raj, MD is from the course Parathyroid Gland Disorders.


    Included Quiz Questions

    1. Increased PTH
    2. Increased mineralized calcium
    3. Increased serum phosphate
    4. Decreased mineralized phosphorus
    5. Increased active vitamin D
    1. Fibrous replacement of resorbed bone
    2. Increased mineralization of bone
    3. Imbalance between calcium and phosphate in bone
    4. Improper deposition of bone
    5. Unregulated action of osteoblasts
    1. Increased cortical bone opacity
    2. "Salt and pepper" appearance
    3. Brown tumor
    4. Tapering of distal clavicle
    5. Subperiosteal bone resorption

    Author of lecture Clinical Features of Primary Hyperparathyroidism & Osteitis Fibrosa Cystica

     Carlo Raj, MD

    Carlo Raj, MD


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