Penems – Cell Wall Synthesis Inhibitors (Antibiotics)

by Pravin Shukle, MD

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    00:00 Let's move on to the carbapenem.

    00:03 So these are kind of the gorillacillins we like to call them.

    00:07 They are very, very powerful agents.

    00:08 The prototypical agent is imipenem.

    00:11 And the new ones out like meropenem that are taking over.

    00:15 You've notice that I've underlined imipenem and meropenem.

    00:18 These are chemically unique but still containing beta lactam ring.

    00:22 They have lowest susceptibility to the pencillinases.

    00:25 They are very susceptible to renal dehydropeptidases though.

    00:30 So you are going to be administering them with cilastatin which is an inhibitor of that particular enzyme.

    00:37 They have a wide ranging activity against gram positives, gram negatives, anaerobes and most importantly against pseudomonas.

    00:45 Also acinetobacter species are very responsive to carbapenems.

    00:50 So remember that sometimes we have acinetobacter type infections in endocarditis.

    00:55 So we use it certainly in that regard.

    About the Lecture

    The lecture Penems – Cell Wall Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. Cilastatin
    2. Clavulanic acid
    3. Aminoglycosides
    4. Tazobactam
    5. Sulbactam
    1. They do not contain a beta-lactam ring.
    2. They are active against acinetobacter species.
    3. They are active against gram negative rods.
    4. They are active against anaerobes.
    5. They have low susceptibility to penicillinases.

    Author of lecture Penems – Cell Wall Synthesis Inhibitors (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD

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