Paget's Disease of Bone

by Carlo Raj, MD

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    Paget’s Disease of Bone is our topic. Prevalence of the bone disease - United Kingdom, Australia, South Africa, US. And with Paget’s disease of the bone, fundamentally this picture pretty much tells you the story of Paget’s disease. The story… the story began with healthy osteoclast and as the day wore on and as the weeks wore on, years wore on, osteoclast… Mr, Osteoclast kept… kept getting tired and tired, tired until he pretty much died. Huh! So, osteoclast, initially there might be too much chaotic osteoclastic activity and functioning. Therefore, initially, you would expect there to be increased bone resorption, if you take a look at the X-ray here. And on your left, you’ll notice that the bone appears quite lucent. That’s because of increased bone resorption. Keep that in mind. So, therefore, the patient initially might have hypercalcaemia. The story of osteoclastic activity continues and he starts or she starts, whatever, the cells start dying, starts burning out. So, if osteoclastic activity starts dying out, then please understand that there is going to be increase in bone activity. And with that increase bone activity, you are then going to have thickening of the bone as seen in the X-ray in the picture. So, therefore, the picture on the right shows you increased, thickened, white, opaque bone representing osteosclerosis. Now, what I haven’t shown you here is that there is a stage in between whereas I told you there is declining functioning of the osteoclast. So, initially, there was osteolytic lesion, then there will be as the osteoclast burning out a mosaic pattern, ultimately when we have thickening of the bone, it’s called osteosclerosis to the point where you might then cause compression of certain cranial nerves, for example, the vestibulocochlear. And with such nerves being compressed, you might...

    About the Lecture

    The lecture Paget's Disease of Bone by Carlo Raj, MD is from the course Bone Disease.

    Included Quiz Questions

    1. Dysfunctional osteoclast activity
    2. Chaotic osteoblastic activity
    3. Osteosarcoma
    4. Hypercalcemia
    5. Disordered alkaline phosphatase secretion
    1. Increasing height
    2. Enlarged frontal bone
    3. Bowed legs
    4. Pathologic fracture
    5. Cranial nerve impingement
    1. Cotton wool appearance
    2. Spread from skull to other bones
    3. Osteosarcoma
    4. Crew cut sign
    5. Decreasing hat size
    1. Osteolytic, mixed sclerosis and osteolytic, sclerosis
    2. Osteolytic, sclerosis, mixed sclerosis and osteolytic
    3. Osteolytic, sclerosis, ostelytic
    4. Sclerosis, mixed sclerosis and osteolytic, osteolytic
    5. Sclerosis, osteolytic, sclerosis
    1. Isolated alkaline phosphatase elevation
    2. Increased GH accompanied by elevated alkaline phosphatase
    3. Hypercalcemia and hypophosphatemia
    4. Decreased PTH, increased alkaline phosphatase
    5. Hypocalcemia and decreased alkaline phosphatase

    Author of lecture Paget's Disease of Bone

     Carlo Raj, MD

    Carlo Raj, MD

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