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The lecture Other Approaches to Beta Lactamase Issue – Beta Lactam Antibiotics by Adam Le Gresley, PhD is from the course Medical Chemistry.
Included Quiz Questions
What is the role of a sacrificial compound in antibiotic therapy?
- These compounds help to combat with antibiotic-degrading enzymes produced by the antibiotic-resistant bacteria.
- These compounds form a protective shell around the antibiotic molecule and hence protect it from enzymatic attack.
- These compounds prevent the acidic hydrolysis of the antibiotic molecule by proton quenching.
- These compounds protect the antibiotic-resistant bacteria from antibiotic attack by blocking the antibiotic receptors on the cell surface.
- These compounds inhibit the synthesis of antibiotic-degrading enzymes by bacterial cells.
Which of the following is NOT true about clavulanic acid?
- It contains a thiazolidine ring in its structure that hinders the binding of beta-lactamase to penicillin.
- It acts as a sacrificial compound in the treatment of penicillin-resistant bacterial infections.
- It acts as a mechanism-based beta-lactamase inhibitor by irreversibly binding the lactamase molecules.
- It is structurally similar to the penicillin due to the presence of beta-lactam ring.
- It does not contain any antibiotic activity by itself.
Amoxiclav is a…?
- …a mixture of amoxicillin and clavulanic acid.
- …a mixture of azithromycin and clavulanic acid.
- …a mixture of erythromycin and clavulanic acid.
- …a mixture of levofloxacin and clavulanic acid.
- …a mixture of norfloxacin and clavulanic acid.
Cephalosporins are …?
- …bactericidal antibiotics which exhibit more resistance towards acid hydrolysis and beta-lactamases.
- …fungicidal antibiotics and are susceptible to acid hydrolysis.
- …fungicidal antibiotics and are sensitive to beta-lactamase attacks.
- …virucidal agents which inhibit the beta-lactamase enzymes.
- …algicidal agents which destroy the beta-lactamase enzymes.
Author of lecture Other Approaches to Beta Lactamase Issue – Beta Lactam Antibiotics
Adam Le Gresley, PhD
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