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Other Approaches to Beta Lactamase Issue – Beta Lactam Antibiotics

by Adam Le Gresley, PhD
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    The lecture Other Approaches to Beta Lactamase Issue – Beta Lactam Antibiotics by Adam Le Gresley, PhD is from the course Medical Chemistry.


    Included Quiz Questions

    1. These compounds help to combat with antibiotic-degrading enzymes produced by the antibiotic-resistant bacteria.
    2. These compounds form a protective shell around the antibiotic molecule and hence protect it from enzymatic attack.
    3. These compounds prevent the acidic hydrolysis of the antibiotic molecule by proton quenching.
    4. These compounds protect the antibiotic-resistant bacteria from antibiotic attack by blocking the antibiotic receptors on the cell surface.
    5. These compounds inhibit the synthesis of antibiotic-degrading enzymes by bacterial cells.
    1. It contains a thiazolidine ring in its structure that hinders the binding of beta-lactamase to penicillin.
    2. It acts as a sacrificial compound in the treatment of penicillin-resistant bacterial infections.
    3. It acts as a mechanism-based beta-lactamase inhibitor by irreversibly binding the lactamase molecules.
    4. It is structurally similar to the penicillin due to the presence of beta-lactam ring.
    5. It does not contain any antibiotic activity by itself.
    1. …a mixture of amoxicillin and clavulanic acid.
    2. …a mixture of azithromycin and clavulanic acid.
    3. …a mixture of erythromycin and clavulanic acid.
    4. …a mixture of levofloxacin and clavulanic acid.
    5. …a mixture of norfloxacin and clavulanic acid.
    1. …bactericidal antibiotics which exhibit more resistance towards acid hydrolysis and beta-lactamases.
    2. …fungicidal antibiotics and are susceptible to acid hydrolysis.
    3. …fungicidal antibiotics and are sensitive to beta-lactamase attacks.
    4. …virucidal agents which inhibit the beta-lactamase enzymes.
    5. …algicidal agents which destroy the beta-lactamase enzymes.

    Author of lecture Other Approaches to Beta Lactamase Issue – Beta Lactam Antibiotics

     Adam Le Gresley, PhD

    Adam Le Gresley, PhD


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