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Osteoporosis: Risk Factors

by Carlo Raj, MD
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    Nonmodifiable risk factors for osteoporosis: Age; Caucasian or Asian ethnicity; female sex, we talked about menopause; thin body habitus less than 127 pounds due to decreased density, that’s just genetic; positive family history, speaking of genetics with osteoporosis; could be male as well. The modifiable risk factors in which you could have perhaps prevent osteoporosis from taking place. Premature menopause, less than 45 years or hypogonadism; current tobacco use; heavy alcohol use; sedentary lifestyle, big time; dietary deficiency, calcium, vitamin D. All of these could potentially be modified so that you prevent osteoporosis from setting in. It depends on circumstances, but think of-think of these being modifiable. Secondary causes of osteoporosis. Primary causes can’t help it, secondary. Endocrine disorders: hyperthyroidism; hyperparathyroidism, increased PTH causing destruction of the bone; hypogonadism; Cushing’s syndrome with all that glucocorticoid. Bone marrow disorders such as multiple myeloma causing lytic bone lesions; leukemia/lymphoma, often times you’ll have bone issues. Gastrointestinal disorders such as gastrectomy in which now the patient is suffering from malabsorption. Celiac disease would be an example of malabsorption where perhaps you may be losing the ability to properly reabsorb your Vitamin D. Secondary causes: connective tissue diseases such as RA, rheumatoid arthritis; oesteogenisis imperfect: type 1, much more viable with birth; type 2, non-viable, death in utero. Ehlers-Danlos, Marfan… All of these may result in decreased bone density. Drugs, the most common: glucocorticoids, anticonvulsants, cyclosporine, prolonged heparin use is something that you want to keep in mind that may also result in osteoporosis....

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    The lecture Osteoporosis: Risk Factors by Carlo Raj, MD is from the course Bone Disease.


    Author of lecture Osteoporosis: Risk Factors

     Carlo Raj, MD

    Carlo Raj, MD


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