Nonmodifiable risk factors for osteoporosis:
Age; Caucasian or Asian ethnicity; female
sex, we talked about menopause; thin body
habitus less than 127 pounds due to decreased
density, that’s just genetic; positive family
history, speaking of genetics with osteoporosis;
could be male as well.
The modifiable risk factors in which you could
have perhaps prevent osteoporosis from taking
Premature menopause, less than 45 years or
hypogonadism; current tobacco use; heavy alcohol
use; sedentary lifestyle, big time; dietary
deficiency, calcium, vitamin D. All of these
could potentially be modified so that you
prevent osteoporosis from setting in.
It depends on circumstances, but think of-think
of these being modifiable.
Secondary causes of osteoporosis.
Primary causes can’t help it, secondary.
Endocrine disorders: hyperthyroidism; hyperparathyroidism,
increased PTH causing destruction of the bone;
hypogonadism; Cushing’s syndrome with all
Bone marrow disorders such as multiple myeloma
causing lytic bone lesions; leukemia/lymphoma,
often times you’ll have bone issues.
Gastrointestinal disorders such as gastrectomy
in which now the patient is suffering from
Celiac disease would be an example of malabsorption
where perhaps you may be losing the ability
to properly reabsorb your Vitamin D.
Secondary causes: connective tissue diseases
such as RA, rheumatoid arthritis; oesteogenisis
imperfect: type 1, much more viable with birth;
type 2, non-viable, death in utero.
All of these may result in decreased bone
Drugs, the most common: glucocorticoids, anticonvulsants,
cyclosporine, prolonged heparin use is something
that you want to keep in mind that may also
result in osteoporosis.