Mitochondria in Cellular Injury

00:01 Here's a mitochondria being beaten on by injury, not otherwise specified, and that's fine.

00:07 One of the initial events, if the mitochondria is not functioned properly and the membrane is perturbed is that we will get a mitochondrial permeability transition, we'll get a poor in that outer membrane, which means we will lose the proton great in the normal exists between the inner and outer membrane, which means that we will get reduced ATP synthesis.

00:25 So that poor all by itself is damaging to the cell because we're not making enough energy.

00:33 But we will also release from the electron transport chain in the inner mitochondrial membrane cytochrome C, and that cytochrome C is an important component in driving the formation of the apoptosome.

00:46 Apoptosome will refer to it as the seven spoked wheel of death, and the cytochrome C is important for putting this thing together, this seven spoked wheel.

00:57 And once we do that, we will activate enzymes that will cause apoptosis.

01:02 So mitochondrial injury will reduce ATP synthesis, and will also cause cellular suicide.