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Mitochondria in Cellular Injury
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Slides Cellular Pathology Mechanisms of Injury.pdf.pdf
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Reference List Pathology.pdf
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Download Lecture Overview
00:01
Here's a mitochondria
being beaten on by injury,
not otherwise specified,
and that's fine.
00:07
One of the initial events,
if the mitochondria is not functioned
properly and the membrane is perturbed
is that we will get a mitochondrial
permeability transition,
we'll get a poor in that outer membrane,
which means we will lose the proton
great in the normal exists between
the inner and outer membrane,
which means that we will
get reduced ATP synthesis.
00:25
So that poor all by
itself is damaging
to the cell because we're
not making enough energy.
00:33
But we will also release from
the electron transport chain
in the inner mitochondrial
membrane cytochrome C,
and that cytochrome C is
an important component
in driving the formation
of the apoptosome.
00:46
Apoptosome will refer to it as
the seven spoked wheel of death,
and the cytochrome C is important
for putting this thing together,
this seven spoked wheel.
00:57
And once we do that, we will activate
enzymes that will cause apoptosis.
01:02
So mitochondrial injury
will reduce ATP synthesis,
and will also cause
cellular suicide.
About the Lecture
The lecture Mitochondria in Cellular Injury by Richard Mitchell, MD, PhD is from the course Cellular Injury.
Included Quiz Questions
Which of the following is responsible for activating the apoptosis pathway in a mitochondrial injury?
- Cytochrome C
- Proton ions
- Cytochrome P450
- Chloride ions
- Pyruvate
Author of lecture Mitochondria in Cellular Injury
Richard Mitchell, MD, PhD
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Very quick and simple explanation. It helped me understand the overall picture of what the apoptosome is.
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