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Mineralocorticoids and Glucocorticoids – Adrenal Pharmacology

by Pravin Shukle, MD
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    About the Lecture

    The lecture Mineralocorticoids and Glucocorticoids – Adrenal Pharmacology by Pravin Shukle, MD is from the course Endocrine Pharmacology. It contains the following chapters:

    • Steroid Binding is Intracellular
    • Mineralcorticoids
    • Glucocorticoids

    Included Quiz Questions

    1. These steroid hormones bind to intracellular receptors
    2. These steroid hormones bind directly to an intranuclear receptor
    3. These steroid hormones bind to a membrane receptor on the outside of the cell called tyrosine kinase
    4. These steroid hormones bind to a transmembrane receptor on the cell called JAK STAT
    5. There steroid hormones bind to a GPCR
    1. Increased gluconeogenesis, lipolysis, abnormal lipid deposition, immune dysfunction
    2. Decrease of blood pressure, slight drop in sodium, increased urine output
    3. Immune dysfunction, especially T cell function
    4. Inhibit COX-2 to decrease platelet activity
    5. Increase glycogenolysis and lipolysis
    1. Dexamethasone is more potent and lasts longer compared to prednisone
    2. Dexamethasone is topical only while prednisone can be taken orally or via IV
    3. Prednisone comes with multiple warnings associated with it while dexamethasone has a very mild side-effect profile
    4. Prednisone binds to a steroid receptor in the cell while dexamethasone binds to a receptor on the cell membrane
    5. Prednisone is not recommended for children under 9 years, while dexamethasone is not recommended for adults over 65 years of age
    1. Treatment for hypertension
    2. Anti fungal
    3. Treatment for hirsutism
    4. Treatment for adrenal adenoma
    5. Breast cancer therapy
    1. Cushing's syndrome
    2. Addison disease
    3. POTS (paroxysmal orthostatic yachycardia syndrome)
    4. Geriatric orthostatic hypotensive syncope
    5. Cerebral salt wasting syndrome

    Author of lecture Mineralocorticoids and Glucocorticoids – Adrenal Pharmacology

     Pravin Shukle, MD

    Pravin Shukle, MD


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