Types of Ovarian Tumors: Metastatic Ovarian Tumors

by Carlo Raj, MD

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    00:01 Our topic here is metastasis to ovaries tumor.

    00:05 So what does that mean to you? That means that, say for example, I'll give you one big one.

    00:09 Let's say that you have a diffuse type of gastric adenocarcinoma, a diffuse type of gastric adenocarcinoma.

    00:19 Why did I say diffuse? Because it loves to spread.

    00:22 Molecularly, would you tell me what this cancer is missing, so that it loves to spread? The E-cadherin is negative.

    00:32 And think about all the different places that the diffuse gastric adenocarcinoma spreads.

    00:36 which are now your left superclavicular node, your Leser-Trelat sign, and there's something called linitis plastica.

    00:44 And it loves to spread down to ovary.

    00:46 We then call this what? Krukenberg.

    00:48 Let's begin.

    00:49 Overall frequency, 5%.

    00:50 Malignancy, 5%.

    00:52 All groups are affected.

    00:54 Metastasis to the ovaries.

    00:58 Morphology: Usually from other sites or organ.

    01:03 Can be from the breast or GI tract.

    01:05 I told you about the GI, do not forget about the breast.

    01:08 And remember, association with pseudomyxoma peritonei with appendiceal tumor.

    01:13 Yeah, that's important.

    01:15 What does pseudomyxoma peritonei mean to you? That means you have more or less malignant ascites and do not forget that.

    01:25 Krukenberg tumor.

    01:27 Bilateral mestastasis.

    01:29 Bilateral mestastasis from GI.

    01:32 Both ovaries.

    01:33 Characterized by hematogenous spread from your diffused gastric adenocarcinoma to ovary.

    01:40 Upon histologic examination, you'd find these Signet ring cancer cells or Signet ring cells.

    01:46 Important.

    01:47 Why? It should've been in the stomach, but now it's spread down and metastasized to the ovary.

    01:53 The site of origin is usually going to be the stomach.

    About the Lecture

    The lecture Types of Ovarian Tumors: Metastatic Ovarian Tumors by Carlo Raj, MD is from the course Ovarian Diseases.

    Included Quiz Questions

    1. Breast and GI
    2. Lung and GI
    3. Bone and breast
    4. GI and bone
    5. Breast and lung
    1. Signet-ring cancer cells
    2. Large cells with clear cytoplasm and a well-defined border
    3. Neoplastic syncytiotrophoblasts
    4. Glomeruli-like structure of blood vessels
    5. Tall columnar cells lining a cystic lesion filled with serous fluid

    Author of lecture Types of Ovarian Tumors: Metastatic Ovarian Tumors

     Carlo Raj, MD

    Carlo Raj, MD

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