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Introduction to Male Reproductive Endocrinology

by Thad Wilson, PhD
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    00:00 Male Reproductive Endocrinology. We're going to go through one more hypothalamic-pituitary- gonadal axis. This particular one is going to be the hypothalamic-pituitary-testis axis. The couple of interesting and most important hypothalamic nuclei are the preoptic and the supraoptic. So these are the same as the other gonadal axis with the ovaries. It's going to stimulate once again the gonadotropes in the anterior pituitary. So these two axes will release the releasing hormone, gonadotropin-releasing hormone, to the gonadotropes to stimulate the release of luteinizing hormone and follicle-stimulating hormone. The actions of luteinizing hormone and follicle-stimulating hormone: The luteinizing hormone primarily regulates the Leydig cell, the follicle-stimulating hormone primarily the Sertoli cell. So what do these two different cells do? Well, Sertoli cells are going to be involved in spermatogenesis, regulation of growth factors and other regulatory proteins but it's the Leydig cells that make the testosterone.

    01:18 So, luteinizing hormone starts off the process, activates side cleaning enzyme to have cholesterol drop down in the various steroid genesis process to make testosterone. So all the testosterone is going to be occurring here in the Leydig cell. As it's passed over to the Sertoli cell, some of it comes out and the one part that comes out will then be translated in the circulation to the various cells of the body. So what does the Sertoli cell do with the testosterone that it get? It's going to release a little bit of it into help with sperm being developed and maturing. The other portion that happens is there is aromatase located in Sertoli cells and Sertoli cells will use that aromatase to convert testosterone to estradiol and interestingly it's estradiol that helps produce more testosterone. So although you like to think of having males primarily producing testosterone and females primarily producing estradiol, it doesn't work like that. We both make both hormones. It's just the concentration in the blood is different between the various sexes.


    About the Lecture

    The lecture Introduction to Male Reproductive Endocrinology by Thad Wilson, PhD is from the course Reproductive Physiology.


    Author of lecture Introduction to Male Reproductive Endocrinology

     Thad Wilson, PhD

    Thad Wilson, PhD


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