00:01 Hypersensitivity - this is a term that is used to describe immune responses that are inappropriate, either because they are of too great a magnitude or they’re a response to something that we really do not need the immune system to respond to, or they’re occurring at a location in the body where we shouldn’t be getting that type of immune response. 00:26 So hypersensitivity is an exaggerated or inappropriate immune response leading to pathology. 00:34 I think it’s quite important to understand that all of the responses you will be looking at are actually normal immune responses. 00:42 The problem is, they’re being directed towards something that isn’t going to cause you any harm whatsoever, or they’re taking place in a location in the body which it’s not necessary for that type of response to be occurring in, or they’re very exaggerated. 00:57 We can classify hypersensitivity reactions into one of four different types. 01:03 Type I is IgE-mediated mast cell degranulation. 01:10 Type II is cytotoxic antibodies against cell surface antigens. 01:18 Type III is immune complex mediated hypersensitivity. 01:25 And Type IV is delayed type hypersensitivity mediated by T-cells. 01:31 So note that types I, II and III were all mediated by antibody whereas Type IV is mediated by T-cells.
The lecture Introduction to Hypersensitivity by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease.
Type I hypersensitivity is mediated by antibodies of which immunoglobulin (Ig) class?
Which of the following types of hypersensitivity reactions does NOT correctly match its pathophysiology?
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