Introduction to Hypersensitivity

by Peter Delves, PhD

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    00:01 Hypersensitivity - this is a term that is used to describe immune responses that are inappropriate, either because they are of too great a magnitude or they’re a response to something that we really do not need the immune system to respond to, or they’re occurring at a location in the body where we shouldn’t be getting that type of immune response.

    00:26 So hypersensitivity is an exaggerated or inappropriate immune response leading to pathology.

    00:34 I think it’s quite important to understand that all of the responses you will be looking at are actually normal immune responses.

    00:42 The problem is, they’re being directed towards something that isn’t going to cause you any harm whatsoever, or they’re taking place in a location in the body which it’s not necessary for that type of response to be occurring in, or they’re very exaggerated.

    00:57 We can classify hypersensitivity reactions into one of four different types.

    01:03 Type I is IgE-mediated mast cell degranulation.

    01:10 Type II is cytotoxic antibodies against cell surface antigens.

    01:18 Type III is immune complex mediated hypersensitivity.

    01:25 And Type IV is delayed type hypersensitivity mediated by T-cells.

    01:31 So note that types I, II and III were all mediated by antibody whereas Type IV is mediated by T-cells.

    About the Lecture

    The lecture Introduction to Hypersensitivity by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease.

    Included Quiz Questions

    1. IgE
    2. IgA
    3. IgD
    4. IgG
    5. IgM
    1. Type IV: immunoglobulin G or M mediated
    2. Type II: complement system activation
    3. Type II: antibodies against cell surface antigens
    4. Type III: immune complex mediated
    5. Type IV: pre-sensitized CD4+ T cells

    Author of lecture Introduction to Hypersensitivity

     Peter Delves, PhD

    Peter Delves, PhD

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