Immune Tolerance and Autoimmune Regulator (AIRE)

by Peter Delves, PhD

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    About the Lecture

    The lecture Immune Tolerance and Autoimmune Regulator (AIRE) by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease. It contains the following chapters:

    • Immunological Tolerance to Self Antigens
    • The Development of Autoimmune Disease

    Included Quiz Questions

    1. B-cells
    2. Helper T-cells
    3. Cytotoxic T-cells
    4. Regulatory T-cells
    5. Plasma cells
    1. The creation of Tissue Restricted Antigens which leads to negative selection and apoptosis of T cells without central tolerance.
    2. Creating T cells that show anergy in the presence of antigen.
    3. Producing Regulator T cells which recognize T cells with self-antigen and inducing apoptosis.
    4. Creating anti-self antibodies which will help target infected cells and tumor cells.
    5. Facilitating apoptosis in peripheral T cells.
    1. A breakdown in tolerance
    2. Upregulation of genes for AIR
    3. Infection
    4. Peripheral lymphoid tissue destruction
    5. Increase in anergy

    Author of lecture Immune Tolerance and Autoimmune Regulator (AIRE)

     Peter Delves, PhD

    Peter Delves, PhD

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