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Immune Tolerance and Autoimmune Regulator (AIRE) – Autoimmune Diseases

by Peter Delves, PhD
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    About the Lecture

    The lecture Immune Tolerance and Autoimmune Regulator (AIRE) – Autoimmune Diseases by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease. It contains the following chapters:

    • Immunological Tolerance to Self Antigens
    • The Development of Autoimmune Disease

    Included Quiz Questions

    1. B-cells
    2. Helper T-cells
    3. Cytotoxic T-cells
    4. Regulatory T-cells
    5. Plasma cells
    1. The creation of Tissue Restricted Antigens which leads to negative selection and apoptosis of T cells without central tolerance
    2. Creating T cells that show anergy in the presence of antigen
    3. Producing Regulator T cells which recognize T cells with self-antigen and inducing apoptosis
    4. Creating anti-self antibodies which will help target infected cells and tumor cells
    5. Facilitating apoptosis in peripheral T cells
    1. A breakdown in tolerance
    2. Upregulation of genes for AIR
    3. Infection
    4. Peripheral lymphoid tissue destruction
    5. Increase in anergy

    Author of lecture Immune Tolerance and Autoimmune Regulator (AIRE) – Autoimmune Diseases

     Peter Delves, PhD

    Peter Delves, PhD


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