Estrogen and Progesterone Synthesis

by Thad Wilson, PhD

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    Where does the estrogen and progesterone come from and where does this process of synthesis take place? Well, LH is luteinizing hormone and that will bind to theca cells. Theca cells are in the ovary and these particular cells, once the luteinizing hormone binds to them, goes through an enzymatic reaction which increases cyclic AMP. This stimulates a side-chain cleaving enzyme that will convert cholesterol into its next step process. It will go down through a number of biochemical steps and eventually will get to androstenedione and testosterone. Yes, testosterone is being produced in these theca cells. Testosterone is then shared to another cell, which is your granulosis cell. You might ask, well, this seems a little bit odd, you made androstenedione and testosterone and then you're just sharing it with another cell? Why share it? The reason is because theca cells don't have aromatase. Aromatase is an enzyme needed to take androstenedione or testosterone into estradiol and it's estradiol that is the end product that we're looking for in the ovaries. So it shared it across a blood vessel. These granulosis cells have aromatase and therefore can complete the process of making estradiol but it's LH that starts this process off and then the granulosis cells which finish it. You may ask why do granulosis cells only accept the androstenedione? It's because they don't have the enzyme that is necessary to produce androstenedione or testosterone. They're holted at progesterone. This can be seen as a complete process here and again focus on the processes that can be regulated. There are a lot of steps in hormone synthesis and in physiology we're concerned about the regulatory steps. So let's review those regulatory steps. Side-chain cleaving enzyme which is where LH is working on in between cholesterol, right below cholesterol. The...

    About the Lecture

    The lecture Estrogen and Progesterone Synthesis by Thad Wilson, PhD is from the course Reproductive Physiology.

    Included Quiz Questions

    1. FSH receptors
    2. Cholesterol
    3. 17 alpha-hydroxylase
    4. Side-chain cleaving enzyme

    Author of lecture Estrogen and Progesterone Synthesis

     Thad Wilson, PhD

    Thad Wilson, PhD

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