What are the peripheral effects of estradiol? Estradiol increases bone growth by osteoblast.
It increases most all progesterone responses. So if you have estradiol present and
progesterone, progesterone is going to do more work than it can just by itself. It increases
a lot of lipid-profile related items like it decreases your LDL protein but it increases your HDL
protein. In the reproductive organs, it's going to stimulate uterine growth, fallopian tube
growth, breast growth as well as secretions of the cervix and increasing the receptors on the
granulosis cells. One thing I will point out here is that oftentimes after a woman has no longer
has cycles or becomes menopausal, she does lose more bone mineral density. One of the
reasons this occurs is because of lower levels of estradiol. Progesterone has a number of
effects on its own. Progesterone affects milk development and some of the breast tissue that
is going to help for that process to work. In the reproductive organs, you get increase in
endometrial secretions and secretions become thicker. There is also a decrease in endometrial
growth. Finally, there is a small increase in body temperature associated with progesterone
and therefore these items you can think about of being directly related to the endometrium
and to the breast.