Diabetic Ketoacidosis (DKA) – Diabetes Complications

by Carlo Raj, MD

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    We had looked at this earlier, but let’s just make sure that we’re clear about the complication of diabetic ketoacidosis. Remember, it’s much more common or it could be more commonly found with uncontrolled type I diabetes and in type II diabetes, it could be found under severe stressful situations. For example, if you have a type II diabetic who is then undergoing surgery, that’s quite a bit of stress that the patient’s feeling. So, therefore, during that time, if poorly controlled, type II diabetic may start getting into a state of diabetic ketoacidosis. So, what does this mean to you? Biochemically, it means that your breaking down lipid, you’re forced to do so. Would you please take a look at the picture on your right. I want you to take a look at the title of this illustration. In other words, you’re absent of insulin or insufficiency of insulin. Now, in your head, you should be thinking about a seesaw and by seesaw I mean, the balance between insulin and the counter-regulatory hormones referring to your stress hormones and specifically which one would that be here? Glucagon and whenever you have glucagon, then you must be thinking permissive action with cortisol. If glucagon is now winning this battle or found to be in greater abundance, you would expect your muscle to start breaking down glucagon, you would expect your lipids to start breaking down… welcome to lipolysis, beta oxidation within the mitochondrial matrix all because of increased glucagon. Let’s walk down further. What do you end up finding when you breakdown your lipid as triglycerides? Focus on the middle cell, please, and the glycerol would be your backbone and the tri referring to your three fatty acids, these are all being broken down. In the meantime, in the liver,...

    About the Lecture

    The lecture Diabetic Ketoacidosis (DKA) – Diabetes Complications by Carlo Raj, MD is from the course Pancreatic Disease & Diabetes.

    Included Quiz Questions

    1. Acetoacetic acid
    2. Glycerol
    3. Glucose
    4. Amino Acids
    5. Glutamic acid
    1. Release of fatty acids into the blood
    2. Increased ketones
    3. Increased glycogenolysis
    4. Increased protein catabolism
    5. Increased gluconeogenesis
    1. Increased glycolysis
    2. Increased glucagon
    3. Increased glycogenolysis
    4. Increased protein degradation
    5. Increased lipolysis
    1. Anion gap metabolic acidosis
    2. Anion gap respiratory acidosis
    3. Non-anion gap metabolic acidosis
    4. Metabolic alkalosis
    5. Non-anion gap respiratory acidosis
    1. Weight gain
    2. Polyuria
    3. Polydipsia
    4. Abdominal pain
    5. Fruit breath
    1. Hypokalemia
    2. Hypoglycemia
    3. Hypomagnesmia
    4. Hypophosphatemia
    5. Hypovolemia

    Author of lecture Diabetic Ketoacidosis (DKA) – Diabetes Complications

     Carlo Raj, MD

    Carlo Raj, MD

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