Diabetic Glomerulopathy esp. Kimmelstiel-Wilson Disease

by Carlo Raj, MD

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    About the Lecture

    The lecture Diabetic Glomerulopathy esp. Kimmelstiel-Wilson Disease by Carlo Raj, MD is from the course Glomerulonephritis.

    Included Quiz Questions

    1. Osmotic damage to the glomerular capillary endothelial cells is due to glucose entering the cells.
    2. Nonenzymatic glycosylation of GBM leads to increased permeability to proteins.
    3. No answers are incorrect.
    4. All answers are incorrect.
    5. Nonenzymatic glycosylation of arterioles leads to hyalinization.
    1. Hyaline arteriolosclerosis affects the efferent arteriole before the afferent arteriole.
    2. Osmotic damage increases permeability increasing filtration fraction.
    3. Damage to the visceral epithelial cell podocytes due to chronic pyelonephritis.
    4. Increased deposition of type IV collagen leads to decreased filtration fraction.
    5. Damage to the mesangium leads to loss of structural support for the glomerulus.
    1. …type IV collagen with trapped proteins.
    2. …proliferation of parietal epithelial cells.
    3. …weakened visceral epithelial cell processes.
    4. …damaged mesangial cells.
    5. …immune complex deposits.
    1. It occurs more frequently in patients with type II diabetes.
    2. Occurs in approximately 35-45% of patients with type I diabetes.
    3. It is often associated with other renal diseases such as renal papillary necrosis.
    4. It is highly correlated with coexisting glomerulopathy such as membranous glomerulopathy.
    5. It is the most common cause of chronic renal failure in the US.
    1. Hyalinization of the afferent arteriole.
    2. Damage to the mesangial matrix.
    3. Osmotic damage to the tubular epithelial cells.
    4. Fusion of podocytes.
    5. Renal papillary necrosis.

    Author of lecture Diabetic Glomerulopathy esp. Kimmelstiel-Wilson Disease

     Carlo Raj, MD

    Carlo Raj, MD

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