Let’s talk about isotonic now. First and foremost, in the previous lecture series where we laid down
the foundation of our Darrow Yannet box and the shifting of the ICF and ECF, we looked at diarrhea,
and diarrhea, adult diarrhea specifically. There is going to be massive loss of volume.
What volume are you going to always referring first, the ECF volume. That's the volume
that you will refer to first. That ECF volume has then decreased in an isotonic fashion.
Is anything else affected? Not at all. Isotonic net loss of sodium, take a look at this.
There’s an equal decrease in total body sodium and total body water. So therefore, is there going to be
any change in plasma osmolarity? None whatsoever, plasma osmolarity in serum sodium are normal,
a proportionate decrease. The only thing that you’re seeing in adult diarrhea is going to be
an ECF volume in an isotonic fashion. Now, as we go through this, the arrows, what are these arrows
that we’re referring to? You see the ratio of total body sodium and total body water?
Those arrows then represent the magnitude of change that we’re going to see.
The magnitude of that ratio, you see it. The magnitude of that ratio is equal in both total body sodium,
total body water. Plasma osmolarity remains the same. There is no osmotic gradient,
so there’s going to be no shift. ECF volume contracts and that is it. What does that mean?
A decrease in ECF volume. Any change in ECF osmolarity? No. Any change in ICF? Take a look,
everything remains the same. However, there are signs of volume depletion.
What are those signs please? Good, decreased skin turgor, maybe dry mucous membrane.
Are we clear? Examples include adult diarrhea or perhaps loss of whole blood due to hemorrhage.
Isotonic gain of fluid, once again, we’re going to walk through this one quicker because now,
we lay down the foundation. So, say that you’re giving your patient IV fluids such as saline.
Normal saline is 0.9%, right? That is isotonic. That must be understood clinically, not 1.0.
0.9% is normal saline. Okay, if you infused your patient with isotonic saline, maybe perhaps excessively,
there's going to be, take a look at the arrows, increase, magnitude will be the same.
So therefore, the only thing that you do is increase ECF volume but there is no change
in plasma osmolarity. Everything is normal. Next, there is no osmotic gradient. You're not going to have
any shifting between ECF and ICF but you will have ECF volume expansion and that’s it.
But the ICF, take a look, remains normal. Pitting edema and body cavity effusion may be present
because you'll have this fluid where, increasing ECF. Let me ask you a question now. Now be careful.
So, this IV fluid that you're putting into your patient, what are you expanding? The ECF.
Would you tell me the name of the membrane that is specifically in the ECF only?
Is that the capillary membrane or is it the cell membrane, in the ECF? That is your
capillary membrane, right? That capillary membrane, is it permeable to sodium, yes or no? Yes.
So, when you infuse saline, is it possible that that fluid might end up in the interstitium?
Of course, it can. So, could it be transudate and pitting? Yes, it can. Are you seeing this now?
You must understand the fundamentals so that you clearly see your patient and you’re not confused
by the distractions and all the – sometimes we call this medical distractions or decorations or whatnot.
You focus on what you need to so you can come to your patient's diagnosis effectively.
Example, excessive infusion of isotonic saline. Now, I need to obviously take you one step further.
What if you gave too much isotonic saline or you gave it too rapidly? What may then happen?
You might then affect the brain. What part? The pons. What’s that called? Central pontine myelinolysis.
Now, the pathogenesis, really unfamiliar or not purely known but you never give isotonic saline
too rapidly. It might kill your patient or severely cause compromise called central pontine myelinolysis.
Let’s talk about normal saline. It is 0.9%. That must be understood. It is infused in patients
to maintain blood pressure but if you put it in, what then happens? You're filling up
the plasma compartment and you're also filling up the interstitium. Why do we give it?
If we know the plasma compartment is the most important compartment to maintain
then why are we giving IV fluid such as normal saline? Why don't we inject our patient
with albumin and company? Why not just fresh frozen plasma? Because it’s cheap, and it works,
and it helps restore the blood pressure. As expected, some of that normal saline, if you missed it,
here it is. It enters the interstitium. What is the interstitium outside of the plasma compartment?
What’s the name of the membrane? Good, that is your capillary membrane.
So therefore, it can enter but understand, you'll have enough fluid in the plasma compartment
to raise your blood pressure. Other solutions that are used that are more expensive include
Ringer's lactate and 5% albumin. Here you go. Remember, as a clinician, you are also responsible
for maintaining cost in the hospital. You’d thought that the information and such
but the volume is a lot, you're also responsible for cost in the hospital. You're responsible
for keeping it low. That must be understood for every single board exam.
Ringer’s lactate and albumin would effectively only increase the vascular compartment
but it’s expensive. It’s expensive.